Review
Pharmacology & Pharmacy
Atanu Chakraborty, Andrew J. Ciciriello, Courtney M. Dumont, Ryan M. Pearson
Summary: Nanoparticles show promise in improving spinal cord injury (SCI) treatment by enhancing drug delivery and modulating inflammatory responses. However, challenges related to the complexity of SCI pathophysiology must be overcome for successful application. Multifactorial approaches hold significant potential in addressing proinflammatory and immune dysfunction in SCI to enhance treatment outcomes.
Article
Engineering, Biomedical
Ian Woods, Cian O'Connor, Lisa Frugoli, Sean Kerr, Javier Gutierrez Gonzalez, Martyna Stasiewicz, Tara McGuire, Brenton Cavanagh, Alan Hibbitts, Adrian Dervan, Fergal J. O'Brien
Summary: The study found that Coll-IV/Fn mixture in scaffolds can promote axonal extension of neurons and induce morphological features of astrocytes. By using materials of different stiffness in the scaffold, astrocyte behavior can be regulated, and the production of anti-inflammatory cytokines can be stimulated.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Andrew J. Ciciriello, Bapurao Surnar, Giovanni D. Medy, Xiaoyu Su, Shanta Dhar, Courtney M. Dumont
Summary: Drug delivery requires precision in timing, location, and dosage. To address the challenges in achieving therapeutic benefits, researchers have developed the BEACON platform, which utilizes an implantable biomaterial as a target for systemically delivered nanoparticles (NPs). The BEACON system has demonstrated temporal dexterity, decreased off-target accumulation, and retention of NPs in the target biomaterial, showing its broad applicability in improving targeted drug delivery.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Bogdan Costachescu, Adelina-Gabriela Niculescu, Marius Gabriel Dabija, Raluca Ioana Teleanu, Alexandru Mihai Grumezescu, Lucian Eva
Summary: This review focuses on the recent advancements in the treatment and repair of spinal cord injuries, including the use of nanocarriers, biomolecules, cell therapies, and biomaterial scaffolds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Amina T. Mneimneh, Mohammed M. Mehanna
Summary: Collagen-based scaffolds play a significant role in promoting regeneration, repair, and recovery of spinal cord injuries by providing a suitable environment for tissue repair, axonal regeneration, and vascularization. They are biocompatible, biodegradable, and widely used in pharmaceutical, cosmetic, food industries, and tissue engineering. Functionalized with different ligands and factors, collagen in scaffolds enhances its binding specificity and activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Neurosciences
Wenwei Jiang, Xuanxuan Zhang, Shumin Yu, Fangsu Yan, Jiaxi Chen, Jinyi Liu, Chuanming Dong
Summary: Functional limitation caused by spinal cord injury (SCI) imposes significant clinical and economic burden. Regenerative biomaterials can create an optimal microenvironment at the site of SCI, promoting neurogenesis, axonal development, and angiogenesis. Decellularized extracellular matrix (dECM) serves as a suitable scaffold for tissue engineering due to its good biocompatibility. However, there are still challenges to be addressed, such as obtaining materials for large-scale use, standardized production mode, the impact of decellularization on the properties of dECM, and the synergistic effect of dECM and cells.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chi Feng, Lan Deng, Yuan-Yuan Yong, Jian-Ming Wu, Da-Lian Qin, Lu Yu, Xiao-Gang Zhou, An-Guo Wu
Summary: The spinal cord and brain are vital to the central nervous system (CNS), but spinal cord injury (SCI) caused by external forces is challenging to treat and results in loss of motor, sensory, and autonomic functions. The incidence of SCI is increasing globally, emphasizing the urgent need for treatments. Various approaches, such as surgery, drug therapy, stem cell transplantation, regenerative medicine, and rehabilitation therapy, have been developed. Among them, biomaterials using tissue engineering and bioscaffolds show promise for transporting cells or drugs to injured sites. However, clinical evidence for the treatment of SCI with biomaterials remains limited. This review provides inspiration and guidance for future studies and applications of biomaterials in SCI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Tian-Yang Yuan, Jun Zhang, Tong Yu, Jiu-Ping Wu, Qin-Yi Liu
Summary: Spinal cord injury is a challenging central nervous system injury, and 3D bioprinting technology shows potential in nervous system repair. This review discusses the progress of spinal cord tissue engineering and the applications of 3D bioprinting in spinal cord repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Yuanpei Cheng, Yanbo Zhang, Han Wu
Summary: Polymeric fibers fabricated by electrospinning have shown promise in the treatment of SCI, with their ability to mimic the structure and function of nerve fibers and facilitate axon growth and drug delivery. However, challenges and future developments still need to be addressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chen Jin, Yayu Wu, Haipeng Zhang, Bai Xu, Wenbin Liu, Chunnan Ji, Panpan Li, Zhenni Chen, Bing Chen, Jiayin Li, Xianming Wu, Peipei Jiang, Yali Hu, Zhifeng Xiao, Yannan Zhao, Jianwu Dai
Summary: This study created a linearly ordered spinal cord-like structure by placing human spinal cord neural progenitor cells and spinal cord astrocytes on a linearly ordered collagen scaffold. The structure promoted neural and vascular regeneration, inhibited inflammation and glial scar formation, and facilitated neural circuit reconstruction and motor functional recovery. Therefore, this research is of great importance in the treatment of spinal cord injury.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Environmental
Haifeng Liu, Xiaojun Yan, Jingwei Jiu, Jiao Jiao Li, Yuanyuan Zhang, Guishan Wang, Dijun Li, Lei Yan, Yanan Du, Bin Zhao, Bin Wang
Summary: Current approaches for treating spinal cord injury (SCI) mainly involve cell transplantation, but the complex microenvironment created by SCI reduces cell activity and leads to poor therapeutic outcomes. Researchers have developed functional tissue constructs using self-assembled mesenchymal stem cell (MSC) microtissues, which show improved cellular activity and increased secretion of nerve regeneration-related factors. These microtissues have shown therapeutic effects in a rat model of complete spinal cord transection, potentially through mechanisms related to the regulation of response mediator protein 2 (CRMP2) phosphorylation and inhibition of the inflammatory response.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Yuan-huan Ma, Hui-juan Shi, Qing-shuai Wei, Qing-wen Deng, Jia-hui Sun, Zhou Liu, Bi-qin Lai, Ge Li, Ying Ding, Wan-ting Niu, Yuan-shan Zeng, Xiang Zeng
Summary: The study introduces a mechanically enhanced decellularized spinal cord (DSC) scaffold with a thin poly (lactic-co-glycolic acid) (PLGA) outer shell, showing promise for effective in situ neuroengineering after spinal cord injury (SCI).
Article
Engineering, Biomedical
Xiang Zeng, Qing-shuai Wei, Ji-chao Ye, Jun-hua Rao, Mei-guang Zheng, Yuan-huan Ma, Li-zhi Peng, Ying Ding, Bi-qin Lai, Ge Li, Shi-xiang Cheng, Eng-Ang Ling, Inbo Han, Yuan-shan Zeng
Summary: This study assessed the biosafety and efficacy of a three-dimensional gelatin sponge (3D-GS) scaffold in a non-human primate spinal cord injury model. The results demonstrated that the scaffold had good biocompatibility and significant effectiveness in the structural repair of injured spinal cord tissue, making it suitable for the treatment of patients with spinal cord injury.
Review
Biochemistry & Molecular Biology
Wei Xiang, Hui Cao, Hai Tao, Lin Jin, Yue Luo, Fenghua Tao, Ting Jiang
Summary: Spinal cord injury (SCI)-related disabilities are a serious problem that needs urgent treatment. Chitosan-based biomaterials have proven to be effective in promoting SCI repair by promoting neural cell growth, guiding nerve tissue regeneration, delivering nerve growth factors, and serving as a vector for gene therapy. This review aims to introduce recent advances in chitosan-based biomaterials for SCI treatment and highlight their prospects for further application.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Environmental Sciences
Mohsen Rahmanian, Amirali Ghahremani, Prashant Kesharwani, Fatemeh Oroojalian, Amirhossein Sahebkar
Summary: Spinal cord injury has devastating effects on physical, social, and professional well-being. Recent advancements in medical therapy have improved diagnosis and well-being of SCI patients, but options for enhancing neurological outcomes are still limited.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Dominique R. Smith, Daniel J. Margul, Courtney M. Dumont, Mitchell A. Carlson, Mary K. Munsell, Mitchell Johnson, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
BIOTECHNOLOGY AND BIOENGINEERING
(2019)
Article
Engineering, Biomedical
Courtney M. Dumont, Mitchell A. Carlson, Mary K. Munsell, Andrew J. Ciciriello, Katerina Strnadova, Jonghyuck Park, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
ACTA BIOMATERIALIA
(2019)
Article
Obstetrics & Gynecology
Taliya Lantsman, Brandon-Luke Seagle, Junhua Yang, Daniel J. Margul, Jeanmarie Thorne-Spencer, Emily S. Miller, Masha Kocherginsky, Shohreh Shahabi
AMERICAN JOURNAL OF PERINATOLOGY
(2020)
Review
Neurosciences
Christopher Bertucci, Ryan Koppes, Courtney Dumont, Abigail Koppes
BRAIN RESEARCH BULLETIN
(2019)
Article
Materials Science, Biomaterials
Dominique R. Smith, Courtney M. Dumont, Andrew J. Cicirirllo, Amina Guo, Rayindra Tatineni, K. Munsell, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2019)
Article
Cell & Tissue Engineering
Dominique R. Smith, Courtney M. Dumont, Jonghyuck Park, Andrew J. Ciciriello, Amina Guo, Ravindra Tatineni, Brian J. Cummings, Aileen J. Anderson, Lonnie D. Shea
TISSUE ENGINEERING PART A
(2020)
Article
Chemistry, Multidisciplinary
Jonathan M. Zuidema, Courtney M. Dumont, Joanna Wang, Wyndham M. Batchelor, Yi-Sheng Lu, Jinyoung Kang, Alessandro Bertucci, Noel M. Ziebarth, Lonnie D. Shea, Michael J. Sailor
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Nashat Nawafleh, Fatma Kubra Erbay Elibol, Mutabe Aljaghtham, Emre Oflaz, Andrew J. Ciciriello, Courtney M. Dumont, Edward Dauer, Recep M. Gorguluarslan, Teyfik Demir, Emrah Celik
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Medicine, Research & Experimental
S. Ahmed Ali, John E. Hanks, Aaron W. Stebbins, Osama Alkhalili, Samantha T. Cohen, Jessica Y. Chen, Dominique R. Smith, Courtney M. Dumont, Lonnie D. Shea, Norman D. Hogikyan, Eva L. Feldman, Michael J. Brenner
Article
Materials Science, Biomaterials
Andrew J. Ciciriello, Dominique R. Smith, Mary K. Munsell, Sydney J. Boyd, Lonnie D. Shea, Courtney M. Dumont
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Biotechnology & Applied Microbiology
Andrew J. Ciciriello, Dominique R. Smith, Mary K. Munsell, Sydney J. Boyd, Lonnie D. Shea, Courtney M. Dumont
Summary: Combining PEG cell delivery platform with lentiviral-mediated IL-10 overexpression improved mouse E14 spinal progenitor transplant survival, leading to neuronal generation, axon elongation, and remyelination. Functional recovery significantly increased in mice after 4 weeks postinjury, indicating the potential of this system to enhance stem cell-mediated tissue regeneration.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Anatomy & Morphology
Giancarlo Tejeda, Andrew J. Ciciriello, Courtney M. Dumont
Summary: Stem cell therapies have the potential to repair and regenerate tissue in the central nervous system. However, low transplant survival remains a major obstacle. The use of biomaterials can significantly improve the survival of transplanted stem cells by providing protection and controlling the cytotoxic injury environment.
CELLS TISSUES ORGANS
(2023)
Article
Engineering, Biomedical
Andrew J. Ciciriello, Bapurao Surnar, Giovanni D. Medy, Xiaoyu Su, Shanta Dhar, Courtney M. Dumont
Summary: Drug delivery requires precision in timing, location, and dosage. To address the challenges in achieving therapeutic benefits, researchers have developed the BEACON platform, which utilizes an implantable biomaterial as a target for systemically delivered nanoparticles (NPs). The BEACON system has demonstrated temporal dexterity, decreased off-target accumulation, and retention of NPs in the target biomaterial, showing its broad applicability in improving targeted drug delivery.
ACTA BIOMATERIALIA
(2022)
Review
Oncology
Daniel Margul, Robert L. Coleman, Thomas J. Herzog
CLINICAL ADVANCES IN HEMATOLOGY & ONCOLOGY
(2020)