Article
Materials Science, Multidisciplinary
Qian Gong, Jing Hong, Ming Ren, Zongjie Shen, Siqi Zhu, Ying Hao, Zhanchi Zhu, Li Li, Lixing Kang, Jiangtao Di, Guosheng Cheng, Qingwen Li
Summary: Nowadays, the use of topographical features and electrical conductivity of scaffolds for cell growth and differentiation is gaining attention in tissue engineering. This study demonstrates a facile approach to growing highly disordered graphene nanosheets on a cheap and weaving quartz-braided structure as a functional scaffold for nerve cell differentiation. The aligned structure integrates conductive graphene, topological surface structure, and provides a flexible platform for nerve cell growth. The HDGN/quartz fabric shows high biocompatibility and electrical conductivity, and when coupled with electrical stimulation, enhances selective neuronal differentiation. This study provides a new material basis for electrically-induced cell growth and differentiation.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Neurosciences
Zhenhui Liu, Yanshi Liu, Maimaiaili Yushan, Aihemaitijiang Yusufu
Summary: The combination of bionic conductive nerve scaffolds and electrical stimulation enhances peripheral nerve regeneration and achieves satisfactory nerve regeneration similar to autologous nerve grafts.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Physical
Ziyu Song, Jiajun Wang, Shaojie Tan, Jing Gao, Lu Wang
Summary: This study combines PCL/gelatin nanofiber membranes with rGO-loaded chitosan non-woven fabrics to prepare biomimetic bilayer skin scaffolds for the treatment of severely damaged wounds. The scaffolds showed good cell proliferation and adhesion, fast re-epithelialization, high conductivity, and improved cell viability. They also enhanced structural stability and moisture absorption, promoting skin tissue regeneration.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Environmental
Ying Ma, Hao Wang, Qiqi Wang, Xiaodong Cao, Huichang Gao
Summary: This study developed a multi-channel nerve guidance conduit (NGC) with dual electrical activity of piezoelectricity and conductivity to enhance peripheral nerve regeneration. In vitro and in vivo experiments demonstrated that the electroactive NGC promoted cell proliferation, differentiation, axonal regeneration, and functional recovery of peripheral nerves, indicating its great potential in repairing peripheral nerve injuries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Pengcheng Sun, Yanjun Guan, Can Yang, Hanqing Hou, Shuang Liu, Boyao Yang, Xiangling Li, Shengfeng Chen, Liu Wang, Huachun Wang, Yunxiang Huang, Xing Sheng, Jiang Peng, Wei Xiong, Yu Wang, Lan Yin
Summary: A fully bioresorbable and conductive nerve scaffold is proposed in this study, which can provide structural guidance and electrical cues for nerve defect repair, promoting nerve regeneration and motor functional recovery. This work is of great significance for improving therapeutic outcomes in regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Shaohua Wu, Ye Qi, Wen Shi, Mitchell Kuss, Shaojuan Chen, Bin Duan
Summary: This study developed conductive PPDO/CNT composite nanofiber yarns, demonstrating their potential for nerve regeneration applications. The PPDO/CNT NYs showed excellent mechanical properties and biocompatibility, and were able to promote cell differentiation and maturation through electrical stimulation.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Review
Engineering, Biomedical
Woo-Youl Maeng, Wan-Ling Tseng, Song Li, Jahyun Koo, Yuan-Yu Hsueh
Summary: This review examines the potential and challenges of using bioelectronic implantable devices for peripheral nerve regeneration. It summarizes modern fabrication methods and integration techniques to deliver effective and controllable electroceuticals.
Article
Chemistry, Physical
Runyi Mao, Bin Yu, Jinjie Cui, Zeying Wang, Xintai Huang, Hongbo Yu, Kaili Lin, Steve G. F. Shen
Summary: This study developed a piezoelectric nerve conduit using a composite of PCL/ZnO nanofiber, which demonstrated faster and superior sciatic nerve repair compared to conventional materials. The piezoelectric stimulation from PZNF increased the expression of nerve growth factor/vascular endothelial growth factor and activated downstream pathways, leading to accelerated nerve repair and function recovery. This novel strategy offers potential for rapid peripheral nerve regeneration.
Review
Health Care Sciences & Services
Sophie Hasiba-Pappas, Lars-P. Kamolz, Hanna Luze, Sebastian P. Nischwitz, Judith C. J. Holzer-Geissler, Alexandru Cristian Tuca, Theresa Rienmueller, Mathias Polz, Daniel Ziesel, Raimund Winter
Summary: The combined application of nerve guidance conduits and electrical stimulation can improve peripheral nerve regeneration in rat models, but there is high variation in treatment protocols and further evaluation under standardized conditions is needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Emanuel Gunnarsson, Kristian Rodby, Fernando Seoane
Summary: Electro-stimulation has been used successfully for years to alleviate spasticity, pain, and increase mobility. The Mollii-suit by Inerventions utilizes dry conductive rubber electrodes, eliminating the need for frequent replacement. However, fitting the garment on the body is cumbersome. This paper presents the possibility of using knitted dry electrodes instead, which have lower skin friction and can easily be fitted to the body. Through validating the performance of the garment using electrical parameters, it is concluded that knitting techniques can produce a seamlessly integrated garment with beneficial manufacturing and comfort perspectives.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Shang Song, Kelly W. McConnell, Danielle Amores, Alexa Levinson, Hannes Vogel, Marco Quarta, Thomas A. Rando, Paul M. George
Summary: Electric stimulation through conductive nerve guides enhances the efficacy of human neural progenitor cells in treating nerve injuries, promoting nerve regeneration and functional recovery.
Review
Clinical Neurology
Lingmei Ni, Zhao Yao, Yifan Zhao, Tianfang Zhang, Jie Wang, Siyue Li, Zuobing Chen
Summary: Peripheral nerve injury is common in extremity trauma patients and surgical therapeutic approaches may not ensure functional recovery. Rehabilitation plays a vital role in promoting nerve repair and sensorimotor recovery through individualized electrical stimulation therapy. However, the parameters and long-term effectiveness of electrical stimulation need further exploration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Physical
Shunyi Lu, Wen Chen, Jiayi Wang, Zilong Guo, Lan Xiao, Lingyu Wei, Jieqin Yu, Ya Yuan, Weisin Chen, Mengxuan Bian, Lei Huang, Yuanyuan Liu, Jian Zhang, Yu-Lin Li, Li-Bo Jiang
Summary: A biodegradable, conductive poly(l-lactide-co-caprolactone)/graphene (PLCL/GN) composite conduit with a micropatterned surface and electrical stimulation capability is developed. It effectively stimulates cell migration, adhesion, and elongation, enhances neuronal expression of SCs, and promotes myelin sheath growth and nerve regeneration in vivo.
Article
Chemistry, Multidisciplinary
Yangnan Hu, Zhuoyue Chen, Hongyang Wang, Jiahui Guo, Jiaying Cai, Xiaoyan Chen, Hao Wei, Jieyu Qi, Qiuju Wang, Huisheng Liu, Yuanjin Zhao, Renjie Chai
Summary: Inspired by the structures of peripheral nerves, researchers have developed a conductive topological scaffold for nerve repair using modified butterfly wings. The scaffold showed increased neurite length and guided cellular orientation, and successfully repaired nerve defects in rats.
Article
Nanoscience & Nanotechnology
Guobao Chen, Chanjuan Dong, Li Yang, Yonggang Lv
ACS APPLIED MATERIALS & INTERFACES
(2015)
Article
Cell & Tissue Engineering
Guobao Chen, Yonggang Lv, Chanjuan Dong, Li Yang
CURRENT STEM CELL RESEARCH & THERAPY
(2015)
Review
Polymer Science
Chanjuan Dong, Yonggang Lv
Article
Engineering, Environmental
Fangyu Qiao, Chanjuan Dong, Dongdong Yao, Zhiling Xu, Yonggang Lv
Summary: The study successfully regulated the polarization of macrophages using 4-octyl itaconate (OI) and enhanced bone integration quality by coating it on demineralized bone matrix (DBM) scaffold with chitosan (CS). Both in vitro and in vivo experiments demonstrated that this metabolite derivative could promote bone repair and improve bone integration through anti-inflammatory effects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Yaping Shen, Yang Zou, Binglin Bie, Chanjuan Dong, Yonggang Lv
Summary: Although mild photothermal therapy (mild-PTT) is limited in its application to deep and internal tumors due to thermal resistance, limited irradiation area, and penetration depth, a strategy based on liquid metal (LM) nanoparticles combined with autophagy activation has been developed for the treatment of bone metastasis and alleviation of bone resorption. The combination of CLALN and mild-PPT effectively inhibits tumor progression, induces impaired autophagy, reduces PD-L1 protein expression, resists thermal resistance, and alleviates immunosuppression. Additionally, it exhibits favorable heat/acid-responsive drug release performance and specifically targets tumor cells at the site of bone metastases.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Biomaterials
Song Li, Chanjuan Dong, Lv Yonggang
Summary: The stiffness of most biomaterials used in bone tissue engineering is currently static, which does not provide an ideal biomimetic dynamic mechanical microenvironment. Researchers have introduced magnetic liquid metal to simulate the dynamic stiffness change during bone repair and successfully prepared a porous magnetic liquid metal scaffold with good biocompatibility, which provides new ideas for bone regeneration and osseointegration.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Biomaterials
Chanjuan Dong, Fangyu Qiao, Guobao Chen, Yonggang Lv
Summary: In this study, bone-derived ECM-incorporated electrospun PCL nanofibrous scaffolds were prepared and evaluated for their effects on osteogenesis in vitro and in vivo. The results demonstrated that the bECM/PCL scaffolds promoted the attachment, proliferation, and osteogenic differentiation of MSCs, while mitigating the foreign-body reaction, ultimately facilitating bone regeneration. This study suggests that bECM can be a promising option for bone regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
