Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair

Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel

(2013) Andrea J. Mothe et al.   BIOMATERIALS

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

(2013) Josephine M. J. Stoffels et al.   BRAIN

A comparison of the behavioral and anatomical outcomes in sub-acute and chronic spinal cord injury models following treatment with human mesenchymal precursor cell transplantation and recombinant decorin

(2013) Stuart I. Hodgetts et al.   EXPERIMENTAL NEUROLOGY

Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix

(2013) Rowena C. Cua et al.   GLIA

Semaphorin 3A Binds to the Perineuronal Nets via Chondroitin Sulfate Type E Motifs in Rodent Brains

(2013) Gunnar Dick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel

(2013) Malgosia M. Pakulska et al.   JOURNAL OF CONTROLLED RELEASE

Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

(2013) H. A. Petrosyan et al.   JOURNAL OF NEUROSCIENCE

Nerve Regeneration Restores Supraspinal Control of Bladder Function after Complete Spinal Cord Injury

(2013) Y.-S. Lee et al.   JOURNAL OF NEUROSCIENCE

Elevated MMP-9 in the Lumbar Cord Early after Thoracic Spinal Cord Injury Impedes Motor Relearning in Mice

(2013) C. N. Hansen et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Integrin-Linked Kinase Regulates Process Extension in Oligodendrocytes via Control of Actin Cytoskeletal Dynamics

(2013) R. W. O'Meara et al.   JOURNAL OF NEUROSCIENCE

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

(2013) C. Soderblom et al.   JOURNAL OF NEUROSCIENCE

Effects of Digesting Chondroitin Sulfate Proteoglycans on Plasticity in Cat Primary Visual Cortex

(2013) V. Vorobyov et al.   JOURNAL OF NEUROSCIENCE

Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex

(2013) C. Romberg et al.   JOURNAL OF NEUROSCIENCE

Chondroitinase Enhances Cortical Map Plasticity and Increases Functionally Active Sprouting Axons after Brain Injury

(2013) Neil G. Harris et al.   JOURNAL OF NEUROTRAUMA

The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain

(2013) Tam Vo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Pathophysiology of the brain extracellular matrix: a new target for remyelination

(2013) Lorraine W. Lau et al.   NATURE REVIEWS NEUROSCIENCE

Arylsulfatase B Improves Locomotor Function after Mouse Spinal Cord Injury

(2013) Myungsik Yoo et al.   PLoS One

Global Analysis of Neuronal Phosphoproteome Regulation by Chondroitin Sulfate Proteoglycans

(2013) Panpan Yu et al.   PLoS One

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix inhibits structural and functional plasticity of dendritic spines in the adult visual cortex

(2013) L. de Vivo et al.   Nature Communications

Laminins in basement membrane assembly

(2013) Erhard Hohenester et al.   Cell Adhesion & Migration

Tenascins and inflammation in disorders of the nervous system

(2012) Igor Jakovcevski et al.   AMINO ACIDS

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

Cortical remyelination: A new target for repair therapies in multiple sclerosis

(2012) Ansi Chang et al.   ANNALS OF NEUROLOGY

Results of a phase II placebo-controlled randomized trial of minocycline in acute spinal cord injury

(2012) Steven Casha et al.   BRAIN

Delayed treatment with chondroitinase ABC promotes sensorimotor recovery and plasticity after stroke in aged rats

(2012) Sara Soleman et al.   BRAIN

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

(2012) Paul Lu et al.   CELL

Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice

(2012) Michelle L. Starkey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chondroitinase ABC promotes plasticity of spinal reflexes following peripheral nerve injury

(2012) Karen D. Bosch et al.   EXPERIMENTAL NEUROLOGY

Tenascin-C and its functions in neuronal plasticity

(2012) Vera Šekeljić et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations in sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice

(2012) Jae-Hyuk Yi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

(2012) Ryoji Tauchi et al.   Journal of Neuroinflammation

Perisynaptic Chondroitin Sulfate Proteoglycans Restrict Structural Plasticity in an Integrin-Dependent Manner

(2012) C. Orlando et al.   JOURNAL OF NEUROSCIENCE

Sialidase, Chondroitinase ABC, and Combination Therapy after Spinal Cord Contusion Injury

(2012) Andrea Mountney et al.   JOURNAL OF NEUROTRAUMA

Persistent cortical plasticity by upregulation of chondroitin 6-sulfation

(2012) Shinji Miyata et al.   NATURE NEUROSCIENCE

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

(2012) Travis L Dickendesher et al.   NATURE NEUROSCIENCE

Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons

(2012) Jessica CF Kwok et al.   Neural Development

Lectican proteoglycans, their cleaving metalloproteinases, and plasticity in the central nervous system extracellular microenvironment

(2012) M.D. Howell et al.   NEUROSCIENCE

A sulfated carbohydrate epitope inhibits axon regeneration after injury

(2012) J. M. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion

(2012) C. Bowes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of Perineuronal and Perisynaptic Extracellular Matrix in Alzheimer's Disease Neuropathology

(2011) Markus Morawski et al.   BRAIN PATHOLOGY

Combination of Multifaceted Strategies to Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Spinal Cord Repair

(2011) Dong H. Hwang et al.   CELL TRANSPLANTATION

Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system

(2011) Santos J. Franco et al.   Developmental Neurobiology

Delayed treatment with Chondroitinase ABC reverses chronic atrophy of rubrospinal neurons following spinal cord injury

(2011) Lucy M. Carter et al.   EXPERIMENTAL NEUROLOGY

Chondroitin sulphate proteoglycans: Key modulators of spinal cord and brain plasticity

(2011) K. Bartus et al.   EXPERIMENTAL NEUROLOGY

Alterations in chondroitin sulfate proteoglycan expression occur both at and far from the site of spinal contusion injury

(2011) Ellen M. Andrews et al.   EXPERIMENTAL NEUROLOGY

Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition

(2011) Lohitash Karumbaiah et al.   GLIA

Sustained release of neurotrophin-3 and chondroitinase ABC from electrospun collagen nanofiber scaffold for spinal cord injury repair

(2011) Ting Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Matrix Metalloproteinase-9 and Stromal Cell-Derived Factor-1 Act Synergistically to Support Migration of Blood-Borne Monocytes into the Injured Spinal Cord

(2011) H. Zhang et al.   JOURNAL OF NEUROSCIENCE

Chondroitinase ABC Promotes Recovery of Adaptive Limb Movements and Enhances Axonal Growth Caudal to a Spinal Hemisection

(2011) S. C. Jefferson et al.   JOURNAL OF NEUROSCIENCE

Integrin Activation Promotes Axon Growth on Inhibitory Chondroitin Sulfate Proteoglycans by Enhancing Integrin Signaling

(2011) C. L. Tan et al.   JOURNAL OF NEUROSCIENCE

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo

(2011) Ying Jin et al.   JOURNAL OF NEUROSCIENCE METHODS

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

(2011) Rong-Rong Zhao et al.   JOURNAL OF NEUROSCIENCE METHODS

Functional regeneration of respiratory pathways after spinal cord injury

(2011) Warren J. Alilain et al.   NATURE

Structural Remodeling of Astrocytes in the Injured CNS

(2011) Daniel Sun et al.   NEUROSCIENTIST

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury

(2011) Haoqian Zhang et al.   Neurotherapeutics

6-Sulphated Chondroitins Have a Positive Influence on Axonal Regeneration

(2011) Rachel Lin et al.   PLoS One

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

Anti-Nogo on the go: from animal models to a clinical trial

(2010) Björn Zörner et al.   Annals of the New York Academy of Sciences

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

Training-induced plasticity in rats with cervical spinal cord injury: Effects and side effects

(2010) Aleksandra Krajacic et al.   BEHAVIOURAL BRAIN RESEARCH

Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

(2010) Daniela Carulli et al.   BRAIN

Injured mice at the gym: Review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury

(2010) Lyn B. Jakeman et al.   BRAIN RESEARCH BULLETIN

Manipulating the glial scar: Chondroitinase ABC as a therapy for spinal cord injury

(2010) Elizabeth J. Bradbury et al.   BRAIN RESEARCH BULLETIN

Chondroitin Sulfate Acts in Concert with Semaphorin 3A to Guide Tangential Migration of Cortical Interneurons in the Ventral Telencephalon

(2010) Geraldine Zimmer et al.   CEREBRAL CORTEX

Controlled release of chondroitinase ABC from fibrin gel reduces the level of inhibitory glycosaminoglycan chains in lesioned spinal cord

(2010) Alex J.T. Hyatt et al.   JOURNAL OF CONTROLLED RELEASE

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-  after Vascular Damage

(2010) C. Schachtrup et al.   JOURNAL OF NEUROSCIENCE

Role of Chondroitin Sulfate Proteoglycans in Axonal Conduction in Mammalian Spinal Cord

(2010) A. S. Hunanyan et al.   JOURNAL OF NEUROSCIENCE

Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord

(2010) S. Karimi-Abdolrezaee et al.   JOURNAL OF NEUROSCIENCE

Extensive scarring induced by chronic intrathecal tubing augmented cord tissue damage and worsened functional recovery after rat spinal cord injury

(2010) Shu-xin Zhang et al.   JOURNAL OF NEUROSCIENCE METHODS

Role of proteoglycans and glycosaminoglycans in the pathogenesis of Alzheimer's disease and related disorders: Amyloidogenesis and therapeutic strategies-A review

(2010) Toshio Ariga et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

(2010) M. Morawski et al.   NEUROSCIENCE

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Sulfation of heparan sulfate associated with amyloid-β plaques in patients with Alzheimer’s disease

(2009) Ilona B. Bruinsma et al.   ACTA NEUROPATHOLOGICA

Laminins

(2009) Madeleine Durbeej   CELL AND TISSUE RESEARCH

Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells

(2009) Elizabeth M. Muir et al.   JOURNAL OF BIOTECHNOLOGY

Versican V2 Assembles the Extracellular Matrix Surrounding the Nodes of Ranvier in the CNS

(2009) M. T. Dours-Zimmermann et al.   JOURNAL OF NEUROSCIENCE

Tenascin-C Is an Inhibitory Boundary Molecule in the Developing Olfactory Bulb

(2009) H. B. Treloar et al.   JOURNAL OF NEUROSCIENCE

An Integrin-Contactin Complex Regulates CNS Myelination by Differential Fyn Phosphorylation

(2009) L. S. Laursen et al.   JOURNAL OF NEUROSCIENCE

Administration of Chondroitinase ABC Rostral or Caudal to a Spinal Cord Injury Site Promotes Anatomical but Not Functional Plasticity

(2009) Veronica J. Tom et al.   JOURNAL OF NEUROTRAUMA

Intrathecal administration of recombinant human N-acetylgalactosamine 4-sulfatase to a MPS VI patient with pachymeningitis cervicalis

(2009) María Verónica Muñoz-Rojas et al.   MOLECULAR GENETICS AND METABOLISM

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

(2009) Guillermo García-Alías et al.   NATURE NEUROSCIENCE

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity

(2009) Renato Frischknecht et al.   NATURE NEUROSCIENCE

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

(2009) Hyunjung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Deoxyribozyme-mediated knockdown of xylosyltransferase-1 mRNA promotes axon growth in the adult rat spinal cord

(2008) Andres Hurtado et al.   BRAIN

Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity

(2008) Sayaka Sugiyama et al.   CELL

Cortical deficiency of laminin γ1 impairs the AKT/GSK-3β signaling pathway and leads to defects in neurite outgrowth and neuronal migration

(2008) Zu-Lin Chen et al.   DEVELOPMENTAL BIOLOGY

Distribution and synthesis of extracellular matrix proteoglycans, hyaluronan, link proteins and tenascin-R in the rat spinal cord

(2008) Clare M. Galtrey et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intraspinal microinjection of chondroitinase ABC following injury promotes axonal regeneration out of a peripheral nerve graft bridge

(2008) Veronica J. Tom et al.   EXPERIMENTAL NEUROLOGY

Sulfated Polysaccharides Promote the Assembly of Amyloid β1–42 Peptide into Stable Fibrils of Reduced Cytotoxicity

(2008) Ramona Bravo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oversulfated Chondroitin Sulfate Plays Critical Roles in the Neuronal Migration in the Cerebral Cortex

(2008) Maki Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biological Functions of the Small Leucine-rich Proteoglycans: From Genetics to Signal Transduction

(2008) Liliana Schaefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

(2008) H. Wang et al.   JOURNAL OF CELL SCIENCE

Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function

(2008) W. B. J. Cafferty et al.   JOURNAL OF NEUROSCIENCE

Inactivation of Glycogen Synthase Kinase 3 Promotes Axonal Growth and Recovery in the CNS

(2008) J. Dill et al.   JOURNAL OF NEUROSCIENCE

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

The Yellow Fluorescent Protein (YFP-H) Mouse Reveals Neuroprotection as a Novel Mechanism Underlying Chondroitinase ABC-Mediated Repair after Spinal Cord Injury

(2008) L. M. Carter et al.   JOURNAL OF NEUROSCIENCE

Induction of MMP-9 Expression and Endothelial Injury by Oxidative Stress after Spinal Cord Injury

(2008) Fengshan Yu et al.   JOURNAL OF NEUROTRAUMA

Single, High-Dose Intraspinal Injection of Chondroitinase Reduces Glycosaminoglycans in Injured Spinal Cord and Promotes Corticospinal Axonal Regrowth after Hemisection but Not Contusion

(2008) Tsutomu Iseda et al.   JOURNAL OF NEUROTRAUMA

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Decorin promotes robust axon growth on inhibitory CSPGs and myelin via a direct effect on neurons

(2008) Kenneth Minor et al.   NEUROBIOLOGY OF DISEASE

Benefit of chondroitinase ABC on sensory axon regeneration in a laceration model of spinal cord injury in the rat

(2008) Lisa B.E. Shields et al.   SURGICAL NEUROLOGY

Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3

(2007) James M. Massey et al.   EXPERIMENTAL NEUROLOGY

Chondroitinase ABC improves basic and skilled locomotion in spinal cord injured cats

(2007) Nicole J. Tester et al.   EXPERIMENTAL NEUROLOGY

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

(2007) Dustin J. Donnelly et al.   EXPERIMENTAL NEUROLOGY