Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
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Title
Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
Authors
Keywords
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Journal
Cancers
Volume 13, Issue 19, Pages 4796
Publisher
MDPI AG
Online
2021-09-27
DOI
10.3390/cancers13194796
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- Sulforaphane retards the growth of UM-UC-3 xenographs, induces apoptosis, and reduces survivin in athymic mice
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- Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
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- Notch Activation Is Dispensable for D, L-Sulforaphane-Mediated Inhibition of Human Prostate Cancer Cell Migration
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- Sulforaphane Induces Cell Cycle Arrest and Apoptosis in Acute Lymphoblastic Leukemia Cells
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- Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway
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- Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China
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- The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
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- Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells
- (2011) Thayele Purayil Hamsa et al. DRUG AND CHEMICAL TOXICOLOGY
- Novel Function of Transcription Factor Nrf2 as an Inhibitor of RON Tyrosine Kinase Receptor-mediated Cancer Cell Invasion
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- Prolonged Sulforaphane Treatment Activates Survival Signaling in Nontumorigenic NCM460 Colon Cells but Apoptotic Signaling in Tumorigenic HCT116 Colon Cells
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- Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice
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- Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design
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- Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells
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- Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells
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- Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53
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- Mechanisms of action of isothiocyanates in cancer chemoprevention: an update
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- Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
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- Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells
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- Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway
- (2010) Dong-Oh Moon et al. CANCER LETTERS
- Sulforaphane Inhibits Constitutive and Interleukin-6-Induced Activation of Signal Transducer and Activator of Transcription 3 in Prostate Cancer Cells
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- New Biomarkers for Monitoring the Levels of Isothiocyanates in Humans
- (2010) Anoop Kumar et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells
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- The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer
- (2010) Maria H Traka et al. Molecular Cancer
- DNA damage and repair activity after broccoli intake in young healthy smokers
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- p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells
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- Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines
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- Cancer Prevention With Natural Compounds
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- Sulforaphane- and Phenethyl Isothiocyanate–Induced Inhibition of Aflatoxin B1–Mediated Genotoxicity in Human Hepatocytes: Role of GSTM1 Genotype and CYP3A4 Gene Expression
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- Inhibition of Autophagy Potentiates Sulforaphane-Induced Apoptosis in Human Colon Cancer Cells
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- Sulforaphane Inhibits Prostate Carcinogenesis and Pulmonary Metastasis in TRAMP Mice in Association with Increased Cytotoxicity of Natural Killer Cells
- (2009) S. V. Singh et al. CANCER RESEARCH
- Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620
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- Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-κB-DNA-binding activity in human bladder T24 cells
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- Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy
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- Perspectives for Cancer Prevention With Natural Compounds
- (2009) A.R.M. Ruhul Amin et al. JOURNAL OF CLINICAL ONCOLOGY
- D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells
- (2009) S.-H. Kim et al. MOLECULAR CANCER THERAPEUTICS
- Effect of Broccoli Intake on Markers Related to Oxidative Stress and Cancer Risk in Healthy Smokers and Nonsmokers
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- Cellular Responses to Cancer Chemopreventive Agent D,L-Sulforaphane in Human Prostate Cancer Cells Are Initiated by Mitochondrial Reactive Oxygen Species
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- Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6
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- The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration
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- Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
- (2008) Woo Young Choi et al. BIOMEDICINE & PHARMACOTHERAPY
- Multi-targeted prevention of cancer by sulforaphane
- (2008) John D. Clarke et al. CANCER LETTERS
- Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells
- (2008) Anwar Anwar-Mohamed et al. CANCER LETTERS
- Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
- (2008) Olga Azarenko et al. CARCINOGENESIS
- Activation of NF-E2-Related Factor-2 Reverses Biochemical Dysfunction of Endothelial Cells Induced by Hyperglycemia Linked to Vascular Disease
- (2008) M. Xue et al. DIABETES
- Sulforaphane targets pancreatic tumour-initiating cells by NF- B-induced antiapoptotic signalling
- (2008) G Kallifatidis et al. GUT
- Sulforaphane inhibited expression of hypoxia‐inducible factor‐1α in human tongue squamous cancer cells and prostate cancer cells
- (2008) Hua Yao et al. INTERNATIONAL JOURNAL OF CANCER
- Sulforaphane Induces Cell-Cycle Arrest and Apoptosis in Cultured Human Lung Adenocarcinoma LTEP-A2 Cells and Retards Growth of LTEP-A2 Xenografts in Vivo
- (2008) Hao Liang et al. JOURNAL OF NATURAL PRODUCTS
- Regulation of estrogen receptor α expression in human breast cancer cells by sulforaphane
- (2008) Marcela Cortes Ramirez et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Binding to Protein by Isothiocyanates: A Potential Mechanism for Apoptosis Induction in Human Nonsmall Lung Cancer Cells
- (2008) Lixin Mi et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic Signalling Pathways in the Prostate
- (2008) Maria Traka et al. PLoS One
- Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells
- (2008) Suvarna Bhamre et al. PROSTATE
- Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines
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