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Title
Sulfoaphane - role in aging and neurodegeneration
Authors
Keywords
Proteasome, Oxidative stress, Nrf2, NF-κB, HDAC
Journal
GeroScience
Volume -, Issue -, Pages -
Publisher
Springer Nature
Online
2019-04-02
DOI
10.1007/s11357-019-00061-7
References
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Note: Only part of the references are listed.- Nrf2: Molecular and epigenetic regulation during aging
- (2018) A. Silva-Palacios et al. AGEING RESEARCH REVIEWS
- Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
- (2018) Fangfang Zhao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- The Effects of Combinatorial Genistein and Sulforaphane in Breast Tumor Inhibition: Role in Epigenetic Regulation
- (2018) Bidisha Paul et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sulforaphane rescues amyloid-β peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
- (2018) Kyoung A. Jhang et al. Journal of Neuroinflammation
- Sulforaphane attenuates postnatal proteasome inhibition and improves spatial learning in adult mice
- (2018) Aditya Sunkaria et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Protective Effects of Sulforaphane on Cognitive Impairments and AD-like Lesions in Diabetic Mice are Associated with the Upregulation of Nrf2 Transcription Activity
- (2018) Die Pu et al. NEUROSCIENCE
- Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells
- (2018) Lulu Zhou et al. Redox Biology
- Sulforaphane Alleviates Lipopolysaccharide-induced Spatial Learning and Memory Dysfunction in Mice: The Role of BDNF-mTOR Signaling Pathway
- (2018) Jie Gao et al. NEUROSCIENCE
- A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells
- (2017) Kendra Royston et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Proteasome Structure and Assembly
- (2017) Lauren Budenholzer et al. JOURNAL OF MOLECULAR BIOLOGY
- KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
- (2017) Albena T. Dinkova-Kostova et al. TRENDS IN FOOD SCIENCE & TECHNOLOGY
- Targeting Free Radicals in Oxidative Stress-Related Human Diseases
- (2017) Patrik Poprac et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress
- (2017) Eri Kubo et al. Scientific Reports
- Reconstructing Biosynthetic Pathway of the Plant-Derived Cancer Chemopreventive-Precursor Glucoraphanin in Escherichia coli
- (2017) Han Yang et al. ACS Synthetic Biology
- Beneficial Effects of Sulforaphane Treatment in Alzheimer's Disease May Be Mediated through Reduced HDAC1/3 and Increased P75NTR Expression
- (2017) Jingzhu Zhang et al. Frontiers in Aging Neuroscience
- 18α-Glycyrrhetinic Acid Proteasome Activator Decelerates Aging and Alzheimer's Disease Progression in Caenorhabditis elegans and Neuronal Cultures
- (2016) Nikoletta Papaevgeniou et al. ANTIOXIDANTS & REDOX SIGNALING
- Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice
- (2016) Brigitte E. Townsend et al. EXPERIMENTAL GERONTOLOGY
- A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system
- (2016) Takuya Iizumi et al. Journal of Neuroinflammation
- Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia
- (2016) Vicente Hernandez-Rabaza et al. Journal of Neuroinflammation
- Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease
- (2016) Manuela Pennisi et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways
- (2016) Jisung Kim et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals
- (2016) Yuanyuan Li et al. Epigenomics
- Sulforaphane protects against rotenone-induced neurotoxicity in vivo: Involvement of the mTOR, Nrf2 and autophagy pathways
- (2016) Qian Zhou et al. Scientific Reports
- Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases
- (2015) Niki Chondrogianni et al. AGEING RESEARCH REVIEWS
- Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- (2015) Stephanie M. Tortorella et al. ANTIOXIDANTS & REDOX SIGNALING
- 20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
- (2015) Niki Chondrogianni et al. FASEB JOURNAL
- Oxidative stress response and Nrf2 signaling in aging
- (2015) Hongqiao Zhang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Epigenetic linkage of aging, cancer and nutrition
- (2015) M. Daniel et al. JOURNAL OF EXPERIMENTAL BIOLOGY
- Sulforaphane Ameliorates Okadaic Acid-Induced Memory Impairment in Rats by Activating the Nrf2/HO-1 Antioxidant Pathway
- (2015) Subhash Dwivedi et al. MOLECULAR NEUROBIOLOGY
- Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways
- (2015) Minhee Jang et al. MOLECULAR NEUROBIOLOGY
- Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract
- (2015) Lauren L. Atwell et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- The emerging role of redox-sensitive Nrf2–Keap1 pathway in diabetes
- (2015) Elango Bhakkiyalakshmi et al. PHARMACOLOGICAL RESEARCH
- Sulforaphane, a naturally occurring isothiocyanate, exhibits anti-inflammatory effects by targeting GSK3β/Nrf-2 and NF-κB pathways in T cells
- (2015) Rahul Checker et al. Journal of Functional Foods
- Redox theory of aging
- (2015) Dean P. Jones Redox Biology
- Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood
- (2015) Yumi Shirai et al. PLoS One
- Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts
- (2014) Diana Gabriel et al. AGING CELL
- Glucosinolate metabolism, functionality and breeding for the improvement of Brassicaceae vegetables
- (2014) Masahiko Ishida et al. BREEDING SCIENCE
- Diet, the Gut Microbiome, and Epigenetics
- (2014) Meredith A. J. Hullar et al. CANCER JOURNAL
- Progeria: A Paradigm for Translational Medicine
- (2014) Leslie B. Gordon et al. CELL
- Proteasome activation delays aging in vitro and in vivo
- (2014) Niki Chondrogianni et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease
- (2014) Yanying Liu et al. JOURNAL OF NEUROCHEMISTRY
- Sulforaphane reduces vascular inflammation in mice and prevents TNF-α-induced monocyte adhesion to primary endothelial cells through interfering with the NF-κB pathway
- (2014) Palanisamy Nallasamy et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Isothiocyanate metabolism, distribution, and interconversion in mice following consumption of thermally processed broccoli sprouts or purified sulforaphane
- (2014) Gregory V. Bricker et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Glucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs
- (2014) Liping Guo et al. Journal of Functional Foods
- The role of protein clearance mechanisms in organismal ageing and age-related diseases
- (2014) David Vilchez et al. Nature Communications
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Nrf2 signaling is impaired in the aging RPE given an oxidative insult
- (2013) Mira M. Sachdeva et al. EXPERIMENTAL EYE RESEARCH
- Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice
- (2013) Bin Li et al. EXPERIMENTAL NEUROLOGY
- Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood–brain barrier disruption and neurological deficits in stroke
- (2013) Alessio Alfieri et al. FREE RADICAL BIOLOGY AND MEDICINE
- Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes
- (2013) Stefanie Grünwald et al. Genes and Nutrition
- Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
- (2013) Yang Bai et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease
- (2013) Fabiana Morroni et al. NEUROTOXICOLOGY
- Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin
- (2013) Donato Angelino et al. Journal of Functional Foods
- The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba)
- (2012) Sameer Khalil Ghawi et al. FOOD CHEMISTRY
- Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging
- (2012) Sarah J. Chapple et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress
- (2012) Andrew M. Pickering et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect
- (2011) Fulvia Zanichelli et al. AGE
- Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism
- (2011) Agnieszka Jazwa et al. ANTIOXIDANTS & REDOX SIGNALING
- Modification of Keap1 Cysteine Residues by Sulforaphane
- (2011) Chenqi Hu et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Nrf2 and NF-κB Modulation by Sulforaphane Counteracts Multiple Manifestations of Diabetic Neuropathy in Rats and High Glucose-Induced Changes
- (2011) Geeta Negi et al. CURRENT NEUROVASCULAR RESEARCH
- An Antiaging and Regenerative Medicine Approach to Optimal Skin Health
- (2011) Allison Pontius et al. FACIAL PLASTIC SURGERY
- Sulforaphane inhibits mitochondrial permeability transition and oxidative stress
- (2011) Tiffany Greco et al. FREE RADICAL BIOLOGY AND MEDICINE
- Sulforaphane Absorption and Excretion Following Ingestion of a Semi-Purified Broccoli Powder Rich in Glucoraphanin and Broccoli Sprouts in Healthy Men
- (2011) Jenna Cramer et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice
- (2011) John D. Clarke et al. PHARMACEUTICAL RESEARCH
- Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells
- (2011) Anna Hsu et al. Clinical Epigenetics
- A single NFκB system for both canonical and non-canonical signaling
- (2010) Vincent Feng-Sheng Shih et al. CELL RESEARCH
- Protective effect of sulforaphane against oxidative stress: Recent advances
- (2010) Carlos Enrique Guerrero-Beltrán et al. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
- Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts
- (2010) Suzanne Kapeta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27
- (2010) Nanqin Gan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines
- (2010) Syed M. Meeran et al. PLoS One
- Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption
- (2010) Ren-Hau Lai et al. Food & Function
- Protection against amyloid beta cytotoxicity by sulforaphane: Role of the proteasome
- (2009) Hyun-Min Park et al. ARCHIVES OF PHARMACAL RESEARCH
- Time dependence of bioactive compounds and antioxidant capacity during germination of different cultivars of broccoli and radish seeds
- (2009) Cristina Martinez-Villaluenga et al. FOOD CHEMISTRY
- The NF- B Family of Transcription Factors and Its Regulation
- (2009) A. Oeckinghaus et al. Cold Spring Harbor Perspectives in Biology
- The Nuclear Factor NF- B Pathway in Inflammation
- (2009) T. Lawrence Cold Spring Harbor Perspectives in Biology
- Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
- (2008) Niki Chondrogianni et al. AGING CELL
- Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
- (2008) A. Tonoki et al. MOLECULAR AND CELLULAR BIOLOGY
- Glucosinolates in Brassica vegetables: The influence of the food supply chain on intake, bioavailability and human health
- (2008) Ruud Verkerk et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates
- (2008) Roderick H Dashwood et al. NUTRITION REVIEWS
- Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response inCaenorhabditis elegans
- (2007) Nate W. Kahn et al. BIOCHEMICAL JOURNAL
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