Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson’s Disease

(2017) Velmarini Vasquez et al.   JOURNAL OF ALZHEIMERS DISEASE

A functional pseudogene,NMRAL2P, is regulated by Nrf2 and serves as a coactivator ofNQO1in sulforaphane-treated colon cancer cells

(2017) Gavin S. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Bromodomain proteins: repairing DNA damage within chromatin

(2017) Li-Ya Chiu et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Oncogenic targetsMmp7,S100a9,NppbandAldh1a3from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam

(2016) Furkan U. Ertem et al.   INTERNATIONAL JOURNAL OF CANCER

Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines

(2016) Ye-Hui Shi et al.   MOLECULES

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

(2016) Ana López-Saavedra et al.   Nature Communications

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection

(2016) Lorenza P. Ferretti et al.   Nature Communications

Interdependence of initial cell density, drug concentration and exposure time revealed by real-time impedance spectroscopic cytotoxicity assay

(2015) C. Caviglia et al.   ANALYST

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

(2015) Praveen Rajendran et al.   Clinical Epigenetics

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

Histone Acetyltransferase 1 Promotes Homologous Recombination in DNA Repair by Facilitating Histone Turnover

(2013) Xiaohan Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation

(2013) Fade Gong et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Initial Cell Seeding Density Influences Pancreatic Endocrine Development During in vitro Differentiation of Human Embryonic Stem Cells

(2013) Blair K. Gage et al.   PLoS One

Inhibiting homologous recombination for cancer therapy

(2012) Sophia B. Chernikova et al.   CANCER BIOLOGY & THERAPY

CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair

(2012) Michelle L. Duquette et al.   PLoS Genetics

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

(2011) Praveen Rajendran et al.   Molecular Cancer

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells

(2011) Praveen Rajendran et al.   Clinical Epigenetics

Hdac3 Is Essential for the Maintenance of Chromatin Structure and Genome Stability

(2010) Srividya Bhaskara et al.   CANCER CELL

Dietary constituents of broccoli and other cruciferous vegetables: Implications for prevention and therapy of cancer

(2010) Ingrid Herr et al.   CANCER TREATMENT REVIEWS

DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer

(2010) Frank A. Sinicrope   Nature Reviews Clinical Oncology

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

N Terminus of CtIP Is Critical for Homologous Recombination-mediated Double-strand Break Repair

(2009) Jingsong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors and genomic instability

(2008) Grégory Eot-Houllier et al.   CANCER LETTERS

Targeted therapy for cancer using PARP inhibitors

(2008) Christopher J Lord et al.   CURRENT OPINION IN PHARMACOLOGY

Systemic Treatment of Colorectal Cancer

(2008) Brian M. Wolpin et al.   GASTROENTEROLOGY