Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma
Authors
Keywords
-
Journal
Acta Pharmaceutica Sinica B
Volume 12, Issue 2, Pages 558-580
Publisher
Elsevier BV
Online
2021-09-27
DOI
10.1016/j.apsb.2021.09.019
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease
- (2020) Mohammed Eslam et al. GASTROENTEROLOGY
- Novel mitochondrion‐targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1‐mediating mitophagy in HCC
- (2020) Mengmeng Li et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor
- (2020) Justin A. Caravella et al. JOURNAL OF MEDICINAL CHEMISTRY
- Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake
- (2020) Pengcheng Zhang et al. OncoTargets and Therapy
- First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors
- (2020) Naohiro Okano et al. INVESTIGATIONAL NEW DRUGS
- The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
- (2020) Daqian Xu et al. NATURE
- FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome
- (2020) Fuming Li et al. NATURE CELL BIOLOGY
- Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
- (2020) Richard S. Finn et al. NEW ENGLAND JOURNAL OF MEDICINE
- ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis
- (2020) Junru Chen et al. Oncogenesis
- Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52
- (2020) Wen-liang Wang et al. ACTA PHARMACOLOGICA SINICA
- LncRNA TMPO-AS1 aggravates the development of hepatocellular carcinoma via miR-429/GOT1 axis
- (2020) Xiaolong Liu et al. AMERICAN JOURNAL OF THE MEDICAL SCIENCES
- 3-Bromopyruvate regulates the status of glycolysis and BCNU sensitivity in human hepatocellular carcinoma cells
- (2020) Xiaodong Sun et al. BIOCHEMICAL PHARMACOLOGY
- Long noncoding RNA MSC‐AS1 promotes hepatocellular carcinoma oncogenesis via inducing the expression of phosphoglycerate kinase 1
- (2020) Cong Cao et al. Cancer Medicine
- Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis
- (2020) Chang Shao et al. Redox Biology
- Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies
- (2020) Monica Mossenta et al. Cancers
- Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non‐alcoholic steatohepatitis model
- (2020) Yoshio Shimizu et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer
- (2020) Haojie Jin et al. eLife
- Identification of a novel non-ATP-competitive protein kinase inhibitor of PGK1 from marine nature products
- (2020) Yuying Wang et al. BIOCHEMICAL PHARMACOLOGY
- HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications
- (2020) Youbo Zhao et al. Cell Reports
- Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2
- (2019) Xin Lu et al. MOLECULAR CARCINOGENESIS
- Targeting the untargetable KRAS in cancer therapy
- (2019) Pingyu Liu et al. Acta Pharmaceutica Sinica B
- Unraveling the Regulation of Hepatic Gluconeogenesis
- (2019) Xueping Zhang et al. Frontiers in Endocrinology
- Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol
- (2019) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex
- (2019) Renhong Yan et al. NATURE
- Transcriptional factor six2 promotes the competitive endogenous RNA network between CYP4Z1 and pseudogene CYP4Z2P responsible for maintaining the stemness of breast cancer cells
- (2019) Lufeng Zheng et al. Journal of Hematology & Oncology
- TO901317 inhibits the development of Hepatocellular Carcinoma by LXRα/Glut1 decreasing the glycometabolism
- (2019) Ting Xiong et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma
- (2019) Lorenza Rimassa et al. CANCER TREATMENT REVIEWS
- Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans
- (2019) Li Che et al. GUT
- Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Non‐alcoholic Fatty Liver Disease in Murine Fast‐food Diet Model
- (2019) Bharat Bhushan et al. HEPATOLOGY
- Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner
- (2019) Zhaoyu Qin et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Quercetin Inhibits the Proliferation of Glycolysis-Addicted HCC Cells by Reducing Hexokinase 2 and Akt-mTOR Pathway
- (2019) Hongyan Wu et al. MOLECULES
- Hepatocellular Carcinoma
- (2019) Augusto Villanueva NEW ENGLAND JOURNAL OF MEDICINE
- Epigenetics in cancer therapy and nanomedicine
- (2019) Annalisa Roberti et al. Clinical Epigenetics
- Nuclear GAPDH is vital for hypoxia-induced hepatic stellate cell apoptosis and is indicative of aggressive hepatocellular carcinoma behavior
- (2019) Yihang Gong et al. Cancer Management and Research
- Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway
- (2019) Ge Liu et al. FASEB JOURNAL
- MicroRNA-450b-3p inhibits cell growth by targeting phosphoglycerate kinase 1 in hepatocellular carcinoma
- (2019) Zide Chen et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells
- (2019) Li Wang et al. OncoTargets and Therapy
- GLS1 promotes proliferation in hepatocellular carcinoma cells via AKT/GSK3β/CyclinD1 pathway
- (2019) Jianbo Xi et al. EXPERIMENTAL CELL RESEARCH
- hnRNPU/TrkB defines a chromatin accessibility checkpoint for liver injury and NASH pathogenesis
- (2019) Jing Xiong et al. HEPATOLOGY
- Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications
- (2019) Yazun Bashir Jarrar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Differential contribution of pyruvate carboxylation to anaplerosis and cataplerosis during non-gluconeogenic and gluconeogenic conditions in HepG2 cells
- (2019) Siriluck Wattanavanitchakorn et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Tumor suppressor ZHX2 inhibits NAFLD–HCC progression via blocking LPL-mediated lipid uptake
- (2019) Zhuanchang Wu et al. CELL DEATH AND DIFFERENTIATION
- Even Cancer Cells Watch Their Cholesterol!
- (2019) Romain Riscal et al. MOLECULAR CELL
- Metabolic regulation of gene expression by histone lactylation
- (2019) Di Zhang et al. NATURE
- Metabolic rearrangements in primary liver cancers: cause and consequences
- (2019) Letizia Satriano et al. Nature Reviews Gastroenterology & Hepatology
- NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis
- (2019) Haoyan Guo et al. CANCER LETTERS
- ATP citrate lyase: A central metabolic enzyme in cancer
- (2019) Philippe Icard et al. CANCER LETTERS
- Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway
- (2019) La Hu et al. LIFE SCIENCES
- Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma
- (2019) Li Che et al. Frontiers in Oncology
- Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia
- (2018) Jun-Ho Cho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Targeting Glutamine Metabolism for Cancer Treatment
- (2018) Yeon-Kyung Choi et al. Biomolecules & Therapeutics
- Design, synthesis and biological evaluation of novel spiro-pentacylamides as acetyl-CoA carboxylase inhibitors
- (2018) Qiangqiang Wei et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia
- (2018) Jun-Ho Cho et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling
- (2018) Yue-Xiao Xing et al. JOURNAL OF PROTEOME RESEARCH
- Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial
- (2018) Masatoshi Kudo et al. LANCET
- Hepatocellular carcinoma
- (2018) Alejandro Forner et al. LANCET
- Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway
- (2018) Jian-cai Tang et al. LIFE SCIENCES
- Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation
- (2018) Xirui Liu et al. Molecular Cancer
- Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
- (2018) Michael L Schulte et al. NATURE MEDICINE
- Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
- (2018) Ghassan K. Abou-Alfa et al. NEW ENGLAND JOURNAL OF MEDICINE
- Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma
- (2018) Meng-Xi Liu et al. ONCOGENE
- Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism
- (2018) Mingzhu Bai et al. ONCOGENE
- Overexpression of Pyruvate dehydrogenase E1a subunit Inhibits Warburg effect and Induces Cell Apoptosis through Mitochondria-mediated Pathway in Hepatocellular Carcinoma
- (2018) Jihong Sun et al. ONCOLOGY RESEARCH
- Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers
- (2018) Julian A. Gingold et al. TRENDS IN MOLECULAR MEDICINE
- Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin
- (2018) Dannielle DeWaal et al. Nature Communications
- Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer
- (2018) Yekaterina Y. Zaytseva et al. Oncotarget
- Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH
- (2018) Kumiko Shiba et al. Scientific Reports
- The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
- (2018) Mariafrancesca Scalise et al. Frontiers in Chemistry
- Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma
- (2018) James S.V. Lally et al. Cell Metabolism
- Ivosidenib: First Global Approval
- (2018) Sohita Dhillon DRUGS
- Acquired ornithine transcarbamylase deficiency in pediatric and adolescent patients with fibrolamellar hepatocellular carcinoma
- (2018) Allison L. Bartlett et al. PEDIATRIC BLOOD & CANCER
- DT-13 inhibited the proliferation of colorectal cancer via glycolytic metabolism and AMPK/mTOR signaling pathway
- (2018) Xiaohui Wei et al. PHYTOMEDICINE
- Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies
- (2018) Sandro Nuciforo et al. Cell Reports
- The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma
- (2018) Jia You et al. Biomed Research International
- Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
- (2018) Marcus Grohmann et al. CELL
- Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?
- (2018) Mark A. Febbraio et al. Cell Metabolism
- Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity
- (2018) Zhao Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway
- (2018) Binghua Li et al. EBioMedicine
- PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway
- (2018) Lin Tuo et al. Frontiers in Oncology
- Topotecan induces apoptosis via ASCT2 mediated oxidative stress in gastric cancer
- (2018) Lai Wang et al. PHYTOMEDICINE
- Fatty acid synthase (FASN) as a therapeutic target in breast cancer
- (2017) Javier A. Menendez et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6
- (2017) Keane K.Y. Lai et al. GASTROENTEROLOGY
- Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase
- (2017) Shanshan Liu et al. HEPATOLOGY
- Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake
- (2017) Kosuke Kaji et al. INTERNATIONAL JOURNAL OF CANCER
- Encouraging New Uses for Old Drugs
- (2017) Rachel E. Sachs et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
- (2017) Dong Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Establishing the foundation for a novel, first-in-class, fatty acid synthase inhibitor, TVB-2640, for the treatment of NASH
- (2017) G. Duke et al. JOURNAL OF HEPATOLOGY
- Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation
- (2017) Mark Kin Fai Ma et al. JOURNAL OF HEPATOLOGY
- Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
- (2017) Hyo-Jin Kim et al. Journal of Translational Medicine
- Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
- (2017) Jordi Bruix et al. LANCET
- Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
- (2017) Ke Chen et al. Molecular Cancer
- Glucose feeds the TCA cycle via circulating lactate
- (2017) Sheng Hui et al. NATURE
- Fatty acid synthase – Modern tumor cell biology insights into a classical oncology target
- (2017) Douglas Buckley et al. PHARMACOLOGY & THERAPEUTICS
- Methyl jasmonate leads to necrosis and apoptosis in hepatocellular carcinoma cells via inhibition of glycolysis and represses tumor growth in mice
- (2017) Jingjing Li et al. Oncotarget
- Preventive effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on diethylnitrosamine-induced liver tumorigenesis in obese and diabetic mice
- (2017) Koki Obara et al. Oncotarget
- Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia
- (2017) Jun-Ho Cho et al. PLoS Genetics
- Fatty acid-binding protein 5 function in hepatocellular carcinoma through induction of epithelial-mesenchymal transition
- (2017) Takanori Ohata et al. Cancer Medicine
- MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation
- (2017) X Jin et al. Oncogenesis
- GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma
- (2017) Hong-Wei Sun et al. PLoS One
- Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression
- (2017) Jing Yang et al. Scientific Reports
- Expression of Malic Enzymes in Sebaceous Lesions
- (2016) Ting-Fu Su et al. AMERICAN JOURNAL OF DERMATOPATHOLOGY
- Intestinal SGLT1 in metabolic health and disease
- (2016) Anders Lehmann et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Cancer statistics in China, 2015
- (2016) Wanqing Chen et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers
- (2016) Xiaojing Liu et al. Cell Metabolism
- The Emerging Hallmarks of Cancer Metabolism
- (2016) Natalya N. Pavlova et al. Cell Metabolism
- Trends in the Burden of Nonalcoholic Fatty Liver Disease in a United States Cohort of Veterans
- (2016) Fasiha Kanwal et al. Clinical Gastroenterology and Hepatology
- Studies on the biological functions of CPS1 in AFB 1 induced hepatocarcinogenesis
- (2016) Chi Yang et al. GENE
- Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients
- (2016) Ming-Da Wang et al. HEPATOLOGY
- Fructose-bisphosphate aldolase A is a key regulator of hypoxic adaptation in colorectal cancer cells and involved in treatment resistance and poor prognosis
- (2016) Kenji Kawai et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Monoacylglycerol lipase promotes progression of hepatocellular carcinoma via NF-κB-mediated epithelial-mesenchymal transition
- (2016) Weiping Zhu et al. Journal of Hematology & Oncology
- Metformin confers risk reduction for developing hepatocellular carcinoma recurrence after liver resection
- (2016) Kun-Ming Chan et al. LIVER INTERNATIONAL
- Transketolase counteracts oxidative stress to drive cancer development
- (2016) Iris Ming-Jing Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- 2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
- (2016) Minoru Tomizawa et al. Oncology Letters
- Liver fatty acid-binding protein (L-FABP) promotes cellular angiogenesis and migration in hepatocellular carcinoma
- (2016) Chung-Yu Ku et al. Oncotarget
- SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
- (2015) Guang-Ming Huang et al. CANCER LETTERS
- cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
- (2015) Linchong Sun et al. CELL RESEARCH
- Isocitrate Dehydrogenase 2 Suppresses the Invasion of Hepatocellular Carcinoma Cells via Matrix Metalloproteinase 9
- (2015) Guo-Yan Tian et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma
- (2015) Yun-Yong Park et al. HEPATOLOGY
- Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial
- (2015) Andrew X Zhu et al. LANCET ONCOLOGY
- PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth
- (2015) Emily D. Montal et al. MOLECULAR CELL
- Metformin Induces Apoptosis and Downregulates Pyruvate Kinase M2 in Breast Cancer Cells Only When Grown in Nutrient-Poor Conditions
- (2015) Alessandra Silvestri et al. PLoS One
- Functional expression of sodium-glucose transporters in cancer
- (2015) Claudio Scafoglio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Malic enzyme 1 induces epithelial–mesenchymal transition and indicates poor prognosis in hepatocellular carcinoma
- (2015) Duo Wen et al. TUMOR BIOLOGY
- Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions
- (2015) Li Qiang et al. Cell Reports
- Lipolysis and lipases in white adipose tissue – An update
- (2015) Andressa Bolsoni-Lopes et al. Archives of Endocrinology Metabolism
- PKM2 promotes metastasis by recruiting myeloid-derived suppressor cells and indicates poor prognosis for hepatocellular carcinoma
- (2015) Wei-Ren Liu et al. Oncotarget
- Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma
- (2015) Aritro Nath et al. Scientific Reports
- Efficacy and Safety of ETC-1002, a Novel Investigational Low-Density Lipoprotein-Cholesterol–Lowering Therapy for the Treatment of Patients With Hypercholesterolemia and Type 2 Diabetes Mellitus
- (2014) Maria J. Gutierrez et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Pseudogene CYP4Z2P 3′UTR promotes angiogenesis in breast cancer
- (2014) Lufeng Zheng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth
- (2014) Yajuan Gao et al. CANCER LETTERS
- Downregulation of LAT1 expression suppresses cholangiocarcinoma cell invasion and migration
- (2014) Keatdamrong Janpipatkul et al. CELLULAR SIGNALLING
- Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma
- (2014) Grace Guzman et al. DIGESTIVE DISEASES AND SCIENCES
- Expression of Liver X Receptor Correlates with Intrahepatic Inflammation and Fibrosis in Patients with Nonalcoholic Fatty Liver Disease
- (2014) Sang Bong Ahn et al. DIGESTIVE DISEASES AND SCIENCES
- SREBP-1 Has a Prognostic Role and Contributes to Invasion and Metastasis in Human Hepatocellular Carcinoma
- (2014) Chao Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Type 2 diabetes as a redox disease
- (2014) James D Watson LANCET
- Genetic variations in IDH gene as prognosis predictors in TACE-treated hepatocellular carcinoma patients
- (2014) Huiqing Zhang et al. MEDICAL ONCOLOGY
- Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer
- (2014) M. I. Gross et al. MOLECULAR CANCER THERAPEUTICS
- PI3K and cancer: lessons, challenges and opportunities
- (2014) David A. Fruman et al. NATURE REVIEWS DRUG DISCOVERY
- Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges
- (2014) Melissa M. Phillips et al. Cancer Research and Treatment
- HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
- (2014) De Huang et al. Cell Reports
- PTEN antagonises Tcl1/hnRNPK-mediated G6PD pre-mRNA splicing which contributes to hepatocarcinogenesis
- (2013) Xuehui Hong et al. GUT
- Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia
- (2013) Shukui Qin et al. JOURNAL OF CLINICAL ONCOLOGY
- Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
- (2013) Morgan D Fullerton et al. NATURE MEDICINE
- The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma
- (2013) Juan Li et al. TUMOR BIOLOGY
- Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma
- (2013) Ruihua Ma et al. Nature Communications
- Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
- (2012) Taro Hitosugi et al. CANCER CELL
- Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
- (2012) Vikas P. Sukhatme et al. FEBS LETTERS
- The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
- (2012) Chiara Riganti et al. FREE RADICAL BIOLOGY AND MEDICINE
- Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
- (2012) Hashem B. El-Serag GASTROENTEROLOGY
- Design, Synthesis, and Pharmacological Evaluation of Bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl Sulfide 3 (BPTES) Analogs as Glutaminase Inhibitors
- (2012) Krupa Shukla et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fatty acid-binding protein 5 promotes cell proliferation and invasion in human intrahepatic cholangiocarcinoma
- (2012) CHI-YOUNG JEONG et al. ONCOLOGY REPORTS
- Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer
- (2012) Wei Yu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- The Lipogenesis Pathway as a Cancer Target
- (2011) Hanley N. Abramson JOURNAL OF MEDICINAL CHEMISTRY
- p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
- (2011) Peng Jiang et al. NATURE CELL BIOLOGY
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma
- (2010) George P. Kim et al. INVESTIGATIONAL NEW DRUGS
- Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma
- (2010) Ghassan K. Abou-Alfa et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Genetic, structural and biochemical basis of carbamoyl phosphate synthetase 1 deficiency
- (2010) Ana Isabel Martínez et al. MOLECULAR GENETICS AND METABOLISM
- Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
- (2010) S. Suzuki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GLUT1 Expression Is Increased in Hepatocellular Carcinoma and Promotes Tumorigenesis
- (2009) Thomas Amann et al. AMERICAN JOURNAL OF PATHOLOGY
- Novel roles for GAPDH in cell death and carcinogenesis
- (2009) A Colell et al. CELL DEATH AND DIFFERENTIATION
- The molecular determinants of de novo nucleotide biosynthesis in cancer cells
- (2009) Xuemei Tong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1
- (2008) Ana Paula Pereira Da Silva et al. BIOCHEMICAL JOURNAL
- Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases
- (2008) James P. Hardwick BIOCHEMICAL PHARMACOLOGY
- Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma
- (2008) J. Montero et al. CANCER RESEARCH
- Chemoembolization Combined with Pravastatin Improves Survival in Patients with Hepatocellular Carcinoma
- (2008) Hannah Graf et al. DIGESTION
- A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction
- (2008) H. Liu et al. MOLECULAR CANCER THERAPEUTICS
- Sorafenib in Advanced Hepatocellular Carcinoma
- (2008) Josep M. Llovet et al. NEW ENGLAND JOURNAL OF MEDICINE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started