Epigenetics in cancer therapy and nanomedicine

Targeting Epigenetics in Cancer

(2018) Richard L. Bennett et al.   Annual Review of Pharmacology and Toxicology

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

(2018) Eytan M. Stein et al.   BLOOD

Non-coding RNAs, epigenetics, and cancer: tying it all together

(2018) Humberto J. Ferreira et al.   CANCER AND METASTASIS REVIEWS

Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release

(2018) Qi Tang et al.   CURRENT MEDICINAL CHEMISTRY

Current progress and challenges of nanoparticle-based therapeutics in pain management

(2018) Vanesa Andreu et al.   JOURNAL OF CONTROLLED RELEASE

Nucleosidic DNA demethylating epigenetic drugs – A comprehensive review from discovery to clinic

(2018) Khushboo Agrawal et al.   PHARMACOLOGY & THERAPEUTICS

Nanogel-mediated delivery of a cocktail of epigenetic drugs plus doxorubicin overcomes drug resistance in breast cancer cells

(2018) Sivakumar Vijayaraghavalu et al.   Drug Delivery and Translational Research

Combination Therapy With Histone Deacetylase Inhibitors (HDACi) for the Treatment of Cancer: Achieving the Full Therapeutic Potential of HDACi

(2018) Amila Suraweera et al.   Frontiers in Oncology

Clinical epigenetics: seizing opportunities for translation

(2018) María Berdasco et al.   NATURE REVIEWS GENETICS

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

(2017) Maria Dusinska et al.   FOOD AND CHEMICAL TOXICOLOGY

Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity

(2017) Xiaoyan Wu et al.   JOURNAL OF CONTROLLED RELEASE

Pendant HDAC inhibitor SAHA derivatised polymer as a novel prodrug micellar carrier for anticancer drugs

(2017) Jieni Xu et al.   JOURNAL OF DRUG TARGETING

Parameters Affecting the Enhanced Permeability and Retention Effect: The Need for Patient Selection

(2017) Az Alddien Natfji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Epigenetics and immunotherapy: The current state of play

(2017) Jennifer Dunn et al.   MOLECULAR IMMUNOLOGY

Triplet therapy with afatinib, cetuximab, and bevacizumab induces deep remission in lung cancer cells harboring EGFR T790M in vivo

(2017) Kenichiro Kudo et al.   Molecular Oncology

DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes

(2017) Marta I. Sierra et al.   Nanotoxicology

DNA methylation markers for diagnosis and prognosis of common cancers

(2017) Xiaoke Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cancer epigenome: Concepts, challenges, and therapeutic opportunities

(2017) Mark A. Dawson   SCIENCE

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

(2017) Janel Kydd et al.   Pharmaceutics

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy

(2017) Jingjing Li et al.   Scientific Reports

lncRNAs and microRNAs with a role in cancer development

(2016) Julia Liz et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The effect of exposure to nanoparticles and nanomaterials on the mammalian epigenome

(2016) Marta I. Sierra et al.   International Journal of Nanomedicine

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

(2016) Sebastian Moran et al.   LANCET ONCOLOGY

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study

(2016) Kathleen F Pirollo et al.   MOLECULAR THERAPY

Targeting cancer with hyaluronic acid-based nanocarriers: recent advances and translational perspectives

(2016) Ana Cadete et al.   Nanomedicine

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

(2016) Christoph Bock et al.   NATURE BIOTECHNOLOGY

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Epigenetic Determinants of Cancer

(2016) Stephen B. Baylin et al.   Cold Spring Harbor Perspectives in Biology

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations

(2016) Annalisa Roberti et al.   Nature Communications

Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

(2016) Stephan H. Bernhart et al.   Scientific Reports

Nanoparticle formulations of histone deacetylase inhibitors for effective chemoradiotherapy in solid tumors

(2015) Edina C. Wang et al.   BIOMATERIALS

DNA demethylation and invasive cancer: implications for therapeutics

(2015) David Cheishvili et al.   BRITISH JOURNAL OF PHARMACOLOGY

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy

(2015) M. Maio et al.   CLINICAL CANCER RESEARCH

Histone deacetylase inhibitor-polymer conjugate nanoparticles for acid-responsive drug delivery

(2015) Iza Denis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advancements in the delivery of epigenetic drugs

(2015) Samantha A Cramer et al.   Expert Opinion on Drug Delivery

Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health

(2015) Bozena Smolkova et al.   FOOD AND CHEMICAL TOXICOLOGY

Two distinct modes for propagation of histone PTMs across the cell cycle

(2015) Constance Alabert et al.   GENES & DEVELOPMENT

Advanced targeted nanomedicine

(2015) Mohan C.M. Arachchige et al.   JOURNAL OF BIOTECHNOLOGY

Vorinostat, a histone deacetylase (HDAC) inhibitor, promotes cell cycle arrest and re-sensitizes rituximab- and chemo-resistant lymphoma cells to chemotherapy agents

(2015) Kai Xue et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation

(2015) Yoshihiro Matsumura et al.   MOLECULAR CELL

TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients

(2014) R. Bejar et al.   BLOOD

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

(2014) Tuan Hiep Tran et al.   CARBOHYDRATE POLYMERS

Delivery of epidrugs

(2014) Fatima el Bahhaj et al.   DRUG DISCOVERY TODAY

Lipid based nanocarrier system for the potential oral delivery of decitabine: Formulation design, characterization, ex vivo, and in vivo assessment

(2014) Yub Raj Neupane et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

(2014) S. C. Mack et al.   NATURE

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Development of Vorinostat-Loaded Solid Lipid Nanoparticles to Enhance Pharmacokinetics and Efficacy against Multidrug-Resistant Cancer Cells

(2014) Tuan Hiep Tran et al.   PHARMACEUTICAL RESEARCH

Novel Epigenetic Target Therapy for Prostate Cancer: A Preclinical Study

(2014) Ilaria Naldi et al.   PLoS One

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

(2014) J. E. Zuckerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNAi Therapies: Drugging the Undruggable

(2014) S. Y. Wu et al.   Science Translational Medicine

Tumor Vasculature Targeting: A Generally Applicable Approach for Functionalized Nanomaterials

(2014) Feng Chen et al.   Small

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

(2014) Brenton G. Mar et al.   Nature Communications

Pancreatic cancer gene therapy using an siRNA-functionalized single walled carbon nanotubes (SWNTs) nanoplex

(2014) Tommy Anderson et al.   Biomaterials Science

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

(2013) Thavasyappan Thambi et al.   BIOMATERIALS

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

(2013) S. R. Daigle et al.   BLOOD

Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion

(2013) Sivakumar Vijayaraghavalu et al.   CANCER LETTERS

DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer

(2013) F. J. Carmona et al.   Cancer Prevention Research

Lessons from the Cancer Genome

(2013) Levi A. Garraway et al.   CELL

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

The role of genetics in the establishment and maintenance of the epigenome

(2013) Covadonga Huidobro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Design of pH responsive clickable prodrugs applied to histone deacetylase inhibitors: A new strategy for anticancer therapy

(2013) Régis Delatouche et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A double take on bivalent promoters

(2013) P. Voigt et al.   GENES & DEVELOPMENT

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

(2013) Godefridus J. Peters et al.   INVESTIGATIONAL NEW DRUGS

DNA Methylation Signatures Identify Biologically Distinct Thyroid Cancer Subtypes

(2013) Sandra Rodríguez-Rodero et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

How is epigenetic information maintained through DNA replication?

(2013) Varija N Budhavarapu et al.   Epigenetics & Chromatin

Epigenetics advancing personalized nanomedicine in cancer therapy

(2012) Shujun Liu   ADVANCED DRUG DELIVERY REVIEWS

Functionalization of single-walled carbon nanotubes enables efficient intracellular delivery of siRNA targeting MDM2 to inhibit breast cancer cells growth

(2012) Hailong Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Dynamics and Memory of Heterochromatin in Living Cells

(2012) Nathaniel A. Hathaway et al.   CELL

Histone phosphorylation

(2012) Dorine Rossetto et al.   Epigenetics

BRCA1epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer

(2012) Olafur A. Stefansson et al.   Epigenetics

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

DNA methylation profiling in the clinic: applications and challenges

(2012) Holger Heyn et al.   NATURE REVIEWS GENETICS

Epigenetics and the environment: emerging patterns and implications

(2012) Robert Feil et al.   NATURE REVIEWS GENETICS

Ionizing Radiation Induces Stemness in Cancer Cells

(2012) Laura Ghisolfi et al.   PLoS One

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epigenetic inheritance: Uncontested?

(2011) Bing Zhu et al.   CELL RESEARCH

Epigenetic modifications in cancer

(2011) R Kanwal et al.   CLINICAL GENETICS

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

Landscape of TET2 mutations in acute myeloid leukemia

(2011) S Weissmann et al.   LEUKEMIA

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Cancer epigenetics reaches mainstream oncology

(2011) Manuel Rodríguez-Paredes et al.   NATURE MEDICINE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Newly Engineered Magnetic Erythrocytes for Sustained and Targeted Delivery of Anti-Cancer Therapeutic Compounds

(2011) Caterina Cinti et al.   PLoS One

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

microRNA Signature and Expression of Dicer and Drosha Can Predict Prognosis and Delineate Risk Groups in Neuroblastoma

(2010) R.-J. Lin et al.   CANCER RESEARCH

DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response

(2010) Emelyne Dejeux et al.   Molecular Cancer

Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy

(2010) B. Brueckner et al.   MOLECULAR CANCER THERAPEUTICS

Receptor-targeted nanocarriers for therapeutic delivery to cancer

(2010) Bo Yu et al.   MOLECULAR MEMBRANE BIOLOGY

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

MicroRNAs in Cancer

(2009) Ramiro Garzon et al.   Annual Review of Medicine

MicroRNA 29b functions in acute myeloid leukemia

(2009) R. Garzon et al.   BLOOD

Histone deacetylase inhibitor prodrugs in nanoparticle vector enhanced gene expression in human cancer cells

(2009) Yuta Ishii et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Beyond Trastuzumab: Small Molecule Tyrosine Kinase Inhibitors in HER-2-Positive Breast Cancer

(2009) V. Roy et al.   ONCOLOGIST

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL

Dicer, Drosha, and Outcomes in Patients with Ovarian Cancer

(2008) William M. Merritt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

A microRNA DNA methylation signature for human cancer metastasis

(2008) A. Lujambio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA