PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway

Diagnosis, Staging and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

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Macrophages with a deletion of thephosphoenolpyruvate carboxykinase 1(Pck1) gene have a more proinflammatory phenotype

(2018) Chih-Wei Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

(2018) Meng-Xi Liu et al.   ONCOGENE

Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers

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Mitochondrial Complex I activity signals antioxidant response through ERK5

(2018) Abrar Ul Haq Khan et al.   Scientific Reports

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells

(2017) Ruihua Ma et al.   NATURE CELL BIOLOGY

Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis

(2017) Jin Dai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

MicroRNA-124 regulates the radiosensitivity of non-small cell lung cancer cells by targeting TXNRD1

(2017) Chuncheng Hao et al.   Oncology Letters

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

(2017) Xue-li Bian et al.   Nature Communications

TXNRD1 Is an Unfavorable Prognostic Factor for Patients with Hepatocellular Carcinoma

(2017) Binsheng Fu et al.   Biomed Research International

Thioredoxin 1 modulates apoptosis induced by bioactive compounds in prostate cancer cells

(2017) Aida Rodriguez-Garcia et al.   Redox Biology

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver

(2016) Santhosh Satapati et al.   JOURNAL OF CLINICAL INVESTIGATION

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness

(2016) Xiaoxiao Peng et al.   Scientific Reports

The thioredoxin system in breast cancer cell invasion and migration

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Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia

(2015) Haruka Shinohara et al.   CANCER LETTERS

Upregulation of Cytosolic Phosphoenolpyruvate Carboxykinase Is a Critical Metabolic Event in Melanoma Cells That Repopulate Tumors

(2015) Y. Li et al.   CANCER RESEARCH

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

(2015) Emily D. Montal et al.   MOLECULAR CELL

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

Redox-fibrosis: Impact of TGFβ1 on ROS generators, mediators and functional consequences

(2015) Kati Richter et al.   Redox Biology

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

(2014) Ji-Won Park et al.   BMC CANCER

Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

(2014) Anna-Liisa Levonen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tissue thioredoxin reductase-1 expression in astrocytomas of different grades

(2014) Hasan Esen et al.   JOURNAL OF NEURO-ONCOLOGY

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer

(2013) B. Dai et al.   CANCER RESEARCH

A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification

(2013) Sonya V. Iverson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

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Physiological Roles of Mitochondrial Reactive Oxygen Species

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Hallmarks of Cancer: The Next Generation

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Promoter Hypermethylation Mediated Downregulation of FBP1 in Human Hepatocellular Carcinoma and Colon Cancer

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Phase II study of combining sorafenib with metronomic tegafur/uracil for advanced hepatocellular carcinoma

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Sorafenib plus octreotide is an effective and safe treatment in advanced hepatocellular carcinoma: multicenter phase II So.LAR. study

(2009) Salvatore Del Prete et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation

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