ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2019) Andrew X Zhu et al.   LANCET ONCOLOGY

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Targeting Mybbp1a suppresses HCC progression via inhibiting IGF1/AKT pathway by CpG islands hypo-methylation dependent promotion of IGFBP5

(2019) Xiaoyu Weng et al.   EBioMedicine

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis

(2017) An Tang et al.   Abdominal Radiology

Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer

(2016) Xiaojuan Ye et al.   IUBMB LIFE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer

(2016) Wei-Ching Chen et al.   PLoS One

ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer

(2015) Shunrong Ji et al.   CELL RESEARCH

Regulation of c-Myc protein stability by proteasome activator REGγ

(2014) S Li et al.   CELL DEATH AND DIFFERENTIATION

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

(2014) Markus E. Diefenbacher et al.   JOURNAL OF CLINICAL INVESTIGATION

MYC Degradation

(2014) A. S. Farrell et al.   Cold Spring Harbor Perspectives in Medicine

Therapeutic Strategies to Inhibit MYC

(2014) M. R. McKeown et al.   Cold Spring Harbor Perspectives in Medicine

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

(2013) A. S. Farrell et al.   MOLECULAR AND CELLULAR BIOLOGY

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Evaluation of Fbxw7 expression and its correlation with the expression of c-Myc, cyclin E and p53 in human hepatocellular carcinoma

(2012) Kangsheng Tu et al.   HEPATOLOGY RESEARCH

MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma Are Regulated by HMG-CoA Reductase

(2011) Z. Cao et al.   CANCER RESEARCH

Mechanisms of MYC stabilization in human malignancies

(2010) Melissa R. Junttila et al.   CELL CYCLE

Targeting proteins for degradation

(2009) Erin K Schrader et al.   Nature Chemical Biology