Novel mitochondrion‐targeting copper(II) complex induces HK2 malfunction and inhibits glycolysis via Drp1‐mediating mitophagy in HCC

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

(2018) Bela Ozsvari et al.   Aging-US

Metabolic reprogramming in keloid fibroblasts: Aerobic glycolysis and a novel therapeutic strategy

(2018) Qi Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Parkin Mediates Mitophagy to Participate in Cardioprotection Induced by Late Exercise Preconditioning but Bnip3 Does Not

(2018) Yang Yuan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Jolkinolide B inhibits glycolysis by downregulating hexokinase 2 expression through inactivating the Akt/mTOR pathway in non-small cell lung cancer cells

(2018) Xiang Gao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

(2018) Feng Zhang et al.   Theranostics

Leptin Maintained Zinc Homeostasis Against Glutamate-Induced Excitotoxicity by Preventing Mitophagy-Mediated Mitochondrial Activation in HT22 Hippocampal Neuronal Cells

(2018) Mei-fang Jin et al.   Frontiers in Neurology

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

(2018) José Teixeira et al.   Redox Biology

Copper or/and arsenic induces autophagy by oxidative stress-related PI3K/AKT/mTOR pathways and cascaded mitochondrial fission in chicken skeletal muscle

(2018) Yu Wang et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

(2017) Chenxia Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial networking in diabetic left ventricle cardiomyocytes

(2017) Lucia-Doina Popov   MITOCHONDRION

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

The N-terminus of VDAC: Structure, mutational analysis, and a potential role in regulating barrel shape

(2016) Sabbir R. Shuvo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The VDAC channel: Molecular basis for selectivity

(2016) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic significance of synergistic hexokinase-2 and beta2-adrenergic receptor expression in human hepatocelluar carcinoma after curative resection

(2016) Zhi-Feng Zhang et al.   BMC GASTROENTEROLOGY

FUNDC1 regulates mitochondrial dynamics at the ER–mitochondrial contact site under hypoxic conditions

(2016) Wenxian Wu et al.   EMBO JOURNAL

Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

(2016) Farinoosh Fakharnia et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

In silico construction of HK2-VDAC1 complex and investigating the HK2 binding-induced molecular gating mechanism of VDAC1

(2016) Dawei Zhang et al.   MITOCHONDRION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

(2016) Paweł Lis et al.   MOLECULES

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

Autophagy in MCF-7 cancer cells induced by copper complexes

(2016) Katarína Koňariková et al.   Pharmacological Reports

Resistance to chemotherapy is associated with altered glucose metabolism in acute myeloid leukemia

(2016) KUI SONG et al.   Oncology Letters

ROS-Responsive Mitochondria-Targeting Blended Nanoparticles: Chemo- and Photodynamic Synergistic Therapy for Lung Cancer with On-Demand Drug Release upon Irradiation with a Single Light Source

(2016) Caixia Yue et al.   Theranostics

MPTP pore opening proves crucial for experimental pancreatitis

(2015) Katrina Ray   Nature Reviews Gastroenterology & Hepatology

By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice

(2015) Weiqi Dai et al.   Oncotarget

Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma

(2014) Grace Guzman et al.   DIGESTIVE DISEASES AND SCIENCES

A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tumor cells through multiple mechanisms of action

(2014) Wen Zhou et al.   Chemical Science

Targeting hexokinase II to mitochondria to modulate energy metabolism and reduce ischaemia-reperfusion injury in heart

(2013) Rianne Nederlof et al.   BRITISH JOURNAL OF PHARMACOLOGY

Comparative Study of Changes in Energy Metabolism in Rat Cardiomyocytes in Postinfarction Cardiosclerosis and Diabetes Mellitus

(2013) S. A. Afanas’ev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy

(2013) George S Krasnov et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification

(2013) Diren Beyoğlu et al.   HEPATOLOGY

Improving nuclease activity of copper(II)–terpyridine complex through solubilizing and charge effects of glycine

(2013) Wen Zhou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes

(2013) Duraippandi Palanimuthu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

BIRC5/Survivin enhances aerobic glycolysis and drug resistance by altered regulation of the mitochondrial fusion/fission machinery

(2012) J Hagenbuchner et al.   ONCOGENE

The targeted inhibition of mitochondrial Hsp90 overcomes the apoptosis resistance conferred by Bcl-2 in Hep3B cells via necroptosis

(2012) Chunlan Yan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY