The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
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Title
The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
Authors
Keywords
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Journal
Frontiers in Chemistry
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2018-06-22
DOI
10.3389/fchem.2018.00243
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Note: Only part of the references are listed.- CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake
- (2018) Nana Kobayashi et al. Scientific Reports
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- (2017) Elena Puris et al. JOURNAL OF CONTROLLED RELEASE
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- (2017) Pornparn Kongpracha et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
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- (2017) Dae Woo Choi et al. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc
- (2017) Ryuichi Ohgaki et al. MOLECULAR AND CELLULAR BIOLOGY
- Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells
- (2017) Yu Yamamoto et al. NUTRITION RESEARCH
- DNA methylation of amino acid transporter genes in the human placenta
- (2017) C. Simner et al. PLACENTA
- Inhibition of l-type amino acid transporter 1 activity as a new therapeutic target for cholangiocarcinoma treatment
- (2017) Supak Yothaisong et al. TUMOR BIOLOGY
- Glutamine Transport and Mitochondrial Metabolism in Cancer Cell Growth
- (2017) Mariafrancesca Scalise et al. Frontiers in Oncology
- Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment
- (2017) Keitaro Hayashi et al. World Journal of Gastrointestinal Oncology
- Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol
- (2017) David Dickens et al. Scientific Reports
- Mechanisms involved in the transport of mercuric ions in target tissues
- (2016) Christy C. Bridges et al. ARCHIVES OF TOXICOLOGY
- Glutamine transporters in mammalian cells and their functions in physiology and cancer
- (2016) Yangzom D. Bhutia et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons
- (2016) P. Pantham et al. BIOLOGY OF REPRODUCTION
- LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates
- (2016) Arik A. Zur et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- LAT-1 activity of meta -substituted phenylalanine and tyrosine analogs
- (2016) Evan Augustyn et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
- (2016) Y. Cormerais et al. CANCER RESEARCH
- Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
- (2016) Dora C. Tărlungeanu et al. CELL
- l -Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors
- (2016) Kristiina M. Huttunen et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- LAT1 acts as a crucial transporter of amino acids in human thymic carcinoma cells
- (2016) Keitaro Hayashi et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Metformin enhances anti-tumor effect of L-type amino acid transporter 1 (LAT1) inhibitor
- (2016) Seiji Ueno et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs
- (2016) Mikko Gynther et al. MOLECULAR PHARMACEUTICS
- Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC
- (2016) Hüseyin Ilgü et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prostate Cancer Cells in Different Androgen Receptor Status Employ Different Leucine Transporters
- (2016) Hideo Otsuki et al. PROSTATE
- Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells
- (2016) Marc Le Vee et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- SLC38A9: A lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1
- (2015) Manuele Rebsamen et al. Autophagy
- Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2
- (2015) Printip Wongthai et al. CANCER SCIENCE
- The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1
- (2015) Carsten Gram Hansen et al. CELL RESEARCH
- Reciprocal regulation of amino acid import and epigenetic state through Lat1 and EZH2
- (2015) S. G. Dann et al. EMBO JOURNAL
- The role of branched chain amino acid and tryptophan metabolism in rat’s behavioral diversity: Intertwined peripheral and brain effects
- (2015) Eyal Asor et al. EUROPEAN NEUROPSYCHOPHARMACOLOGY
- LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter
- (2015) Lara Napolitano et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Antitumor activity of an anti-CD98 antibody
- (2015) Gregory M. Hayes et al. INTERNATIONAL JOURNAL OF CANCER
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- (2015) Christopher R. Behrens et al. MOLECULAR PHARMACEUTICS
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- (2015) Fredrick J. Rosario et al. Obesity
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- (2015) Ikuko Sasahara et al. PHYSIOLOGY & BEHAVIOR
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
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- (2015) Ruth Milkereit et al. Nature Communications
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- (2014) Bernadette Carroll et al. AMINO ACIDS
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- (2014) Henna Ylikangas et al. ChemMedChem
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- (2014) C Rosilio et al. LEUKEMIA
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- (2014) Lorena Pochini et al. Frontiers in Chemistry
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- CD98 at the crossroads of adaptive immunity and cancer
- (2012) J. M. Cantor et al. JOURNAL OF CELL SCIENCE
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- (2012) Ainara Elorza et al. MOLECULAR CELL
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- Up-regulation of l-Type Amino Acid Transporter 1 (LAT1) in Cultured Rat Retinal Capillary Endothelial Cells in Response to Glucose Deprivation
- (2011) Ryo Matsuyama et al. Drug Metabolism and Pharmacokinetics
- Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound
- (2011) Michael F. Wempe et al. Drug Metabolism and Pharmacokinetics
- miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5
- (2011) Edit Miko et al. FEBS LETTERS
- Solute Carrier Transporters as Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy
- (2011) Takeo Nakanishi et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery
- (2011) Lauri Peura et al. MOLECULAR PHARMACEUTICS
- Molecular basis of substrate-induced permeation by an amino acid antiporter
- (2011) L. Kowalczyk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Reduction of L-Type Amino Acid Transporter 1 mRNA Expression in Brain Capillaries in a Mouse Model of Parkinson's Disease
- (2010) Sumio Ohtsuki et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Brain uptake of ketoprofen–lysine prodrug in rats
- (2010) Mikko Gynther et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Mechanism of substrate recognition and transport by an amino acid antiporter
- (2010) Xiang Gao et al. NATURE
- Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
- (2010) J. H. Lee et al. SCIENCE
- l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth
- (2009) Koji Oda et al. CANCER SCIENCE
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- Structure of a prokaryotic virtual proton pump at 3.2 Å resolution
- (2009) Yiling Fang et al. NATURE
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- One-pot synthesis of 5-phenylimino, 5-thieno or 5-oxo-1,2,3-dithiazoles and evaluation of their antimicrobial and antitumor activity
- (2008) Lidia S. Konstantinova et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
- (2008) Eva M. del Amo et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs
- (2008) Mikko Gynther et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
- (2008) Vadivel Ganapathy et al. PHARMACOLOGY & THERAPEUTICS
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