The One That Got Away: How Macrophage-Derived IL-1β Escapes the Mycolactone-Dependent Sec61 Blockade in Buruli Ulcer

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

(2021) Belinda S Hall et al.   Autophagy

Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages

(2021) Yvonne A Kwaffo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer

(2021) Anthony J. Muleta et al.   PLoS Neglected Tropical Diseases

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

(2021) Lucas Fernando Sérgio Gushiken et al.   Life-Basel

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

(2021) Pratiti Bhadra et al.   BIOCHEMICAL JOURNAL

Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection

(2020) Mélanie Foulon et al.   Science Advances

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

(2020) Min Zhang et al.   CELL

Buruli ulcer: cured by 8 weeks of oral antibiotics?

(2020) Paul D R Johnson   LANCET

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial

(2020) Richard O Phillips et al.   LANCET

Structure of the Inhibited State of the Sec Translocon

(2020) Samuel F. Gérard et al.   MOLECULAR CELL

TLR1/2 and 5 induce elevated cytokine levels from rheumatoid arthritis monocytes independent of ACPA or RF autoantibody status

(2020) Ryan S Thwaites et al.   RHEUMATOLOGY

Genome-wide association study of Buruli ulcer in rural Benin highlights role of two LncRNAs and the autophagy pathway

(2020) Jeremy Manry et al.   Communications Biology

Mycolactone induces cell death by SETD1B-dependent degradation of glutathione

(2020) Birgit Förster et al.   PLoS Neglected Tropical Diseases

Mycolactone toxin induces an inflammatory response by targeting the IL-1β pathway: Mechanistic insight into Buruli ulcer pathophysiology

(2020) M. Foulon et al.   PLoS Pathogens

Spontaneous healing of Mycobacterium ulcerans disease in Australian patients

(2019) Daniel P. O’Brien et al.   PLoS Neglected Tropical Diseases

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

(2019) Guanghui Zong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping the global distribution of Buruli ulcer: a systematic review with evidence consensus

(2019) Hope Simpson et al.   Lancet Global Health

IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

(2019) Erin Fahey et al.   Frontiers in Immunology

Structural Basis of IL-1 Family Cytokine Signaling

(2019) James K. Fields et al.   Frontiers in Immunology

Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents

(2018) Victor Van Puyenbroeck et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

(2018) Joy Ogbechi et al.   Cell Death & Disease

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells

(2018) Anping Song et al.   Scientific Reports

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

(2018) Caroline Demangel et al.   BIOLOGY OF THE CELL

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection

(2018) Aloysius D. Loglo et al.   PeerJ

Overview of the IL-1 family in innate inflammation and acquired immunity

(2017) Charles A. Dinarello   IMMUNOLOGICAL REVIEWS

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Inflammasome and Autophagy Regulation: A Two-way Street

(2017) Qian Sun et al.   MOLECULAR MEDICINE

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycolactone displays anti-inflammatory effects on the nervous system

(2017) Caroline Isaac et al.   PLoS Neglected Tropical Diseases

Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression

(2017) Norman Nausch et al.   PLoS Neglected Tropical Diseases

Susceptibility to Mycobacterium ulcerans Disease (Buruli ulcer) Is Associated with IFNG and iNOS Gene Polymorphisms

(2017) Stéphanie Bibert et al.   Frontiers in Microbiology

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FVB/N Mice Spontaneously Heal Ulcerative Lesions Induced byMycobacterium ulceransand SwitchM. ulceransinto a Low Mycolactone Producer

(2016) Estelle Marion et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer

(2016) Carlos Capela et al.   PLoS Neglected Tropical Diseases

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

(2016) Miriam Bolz et al.   PLoS Neglected Tropical Diseases

Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model

(2015) Sandra Sacre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model

(2015) Rita Silva-Gomes et al.   PLoS Neglected Tropical Diseases

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

(2015) Joy Ogbechi et al.   PLoS Pathogens

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

Inhibitors of TLR8 Reduce TNF Production from Human Rheumatoid Synovial Membrane Cultures

(2014) S. M. Sacre et al.   JOURNAL OF IMMUNOLOGY

Experimental Infection of the Pig with Mycobacterium ulcerans: A Novel Model for Studying the Pathogenesis of Buruli Ulcer Disease

(2014) Miriam Bolz et al.   PLoS Neglected Tropical Diseases

Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen

(2014) José B. Gama et al.   PLoS Neglected Tropical Diseases

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

Selective Blockade of Tumor Necrosis Factor Receptor I Inhibits Proinflammatory Cytokine and Chemokine Production in Human Rheumatoid Arthritis Synovial Membrane Cell Cultures

(2013) Emily M. Schmidt et al.   ARTHRITIS AND RHEUMATISM

Blocking Interleukin-1  Induces a Healing-Associated Wound Macrophage Phenotype and Improves Healing in Type 2 Diabetes

(2013) R. E. Mirza et al.   DIABETES

Efficacy and safety of canakinumab in urticarial vasculitis: An open-label study

(2013) Karoline Krause et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

(2013) Laure Guenin-Macé et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions

(2013) Praxedis Martin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis

(2013) Jessica L. Porter et al.   PLoS One

Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology

(2012) A. D. Greenhalgh et al.   Disease Models & Mechanisms

Inflammasomes in wound healing and fibrosis

(2012) Carol M Artlett   JOURNAL OF PATHOLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Spontaneous Clearance of a Secondary Buruli Ulcer Lesion Emerging Ten Months after Completion of Chemotherapy—A Case Report from Togo

(2012) Marcus Beissner et al.   PLoS Neglected Tropical Diseases

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

(2011) L. Guenin-Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous Clearance of Mycobacterium ulcerans in a Case of Buruli Ulcer

(2011) Claire L. Gordon et al.   PLoS Neglected Tropical Diseases

Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity

(2010) Alvar Grönberg et al.   PLoS One

IL-1β Processing in Host Defense: Beyond the Inflammasomes

(2010) Mihai G. Netea et al.   PLoS Pathogens

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive Signature of CutaneousMycobacterium ulceransInfection in the Peripheral Blood of Patients with Buruli Ulcer Disease

(2009) Richard Phillips et al.   JOURNAL OF INFECTIOUS DISEASES

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

(2009) Caroline Demangel et al.   NATURE REVIEWS MICROBIOLOGY

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis

(2009) P. Hillyer et al.   RHEUMATOLOGY

Mycolactone Is Responsible for the Painlessness of Mycobacterium ulcerans Infection (Buruli Ulcer) in a Murine Study

(2008) J. En et al.   INFECTION AND IMMUNITY