Inhibitors of protein translocation across membranes of the secretory pathway: novel antimicrobial and anticancer agents

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Mitochondrial protein transport in health and disease

(2018) Yilin Kang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors

(2017) Penglei Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells

(2017) Sarah Haßdenteufel et al.   FEBS LETTERS

Multiple pathways facilitate the biogenesis of mammalian tail-anchored proteins

(2017) Joseph Casson et al.   JOURNAL OF CELL SCIENCE

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria

(2016) Jinshan Jin et al.   ChemMedChem

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies

(2016) Reena Chawla et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)

(2016) Victor Van Puyenbroeck et al.   MOLECULAR & CELLULAR PROTEOMICS

Recent advances in engineering nonribosomal peptide assembly lines

(2016) M. Winn et al.   NATURAL PRODUCT REPORTS

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum

(2016) Naama Aviram et al.   NATURE

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

(2016) Rong Zhang et al.   NATURE

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Protein export through the bacterial Sec pathway

(2016) Alexandra Tsirigotaki et al.   NATURE REVIEWS MICROBIOLOGY

Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors

(2015) Jianmei Cui et al.   ChemMedChem

Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening

(2015) Evelien De Waelheyns et al.   JOURNAL OF ANTIBIOTICS

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

(2015) T. Junne et al.   JOURNAL OF CELL SCIENCE

Valinomycin as a Classical Anionophore: Mechanism and Ion Selectivity

(2015) Sofya Kostina Berezin   JOURNAL OF MEMBRANE BIOLOGY

Protein Transport into the Human Endoplasmic Reticulum

(2015) Johanna Dudek et al.   JOURNAL OF MOLECULAR BIOLOGY

Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum

(2015) A Ruiz-Saenz et al.   ONCOGENE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study

(2015) Wolfgang Klein et al.   PLoS One

Mechanisms of Rose Bengal inhibition on SecA ATPase and ion channel activities

(2014) Ying-Hsin Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SecA-mediated targeting and translocation of secretory proteins

(2014) Katerina E. Chatzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Embracing the void—how much do we really know about targeting and translocation to the endoplasmic reticulum?

(2014) Naama Aviram et al.   CURRENT OPINION IN CELL BIOLOGY

ER-associated degradation: Protein quality control and beyond

(2014) Annamaria Ruggiano et al.   JOURNAL OF CELL BIOLOGY

Proteome-wide Subcellular Topologies ofE. coliPolypeptides Database (STEPdb)

(2014) Georgia Orfanoudaki et al.   MOLECULAR & CELLULAR PROTEOMICS

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

(2014) Kurt Vermeire et al.   PLOS BIOLOGY

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells

(2013) Maximilian Linxweiler et al.   BMC CANCER

A Network of Cytosolic Factors Targets SRP-Independent Proteins to the Endoplasmic Reticulum

(2013) Tslil Ast et al.   CELL

Interaction ofPseudomonas aeruginosaExotoxin A with the human Sec61 complex suppresses passive calcium efflux from the endoplasmic reticulum

(2013) Nico Schäuble et al.   Channels

All roads lead to Rome (but some may be harder to travel): SRP-independent translocation into the endoplasmic reticulum

(2013) Tslil Ast et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Specific inhibition of hamster prion protein translocation by the dodecadepsipeptide valinomycin

(2013) Jiyeon Kim et al.   EXPERIMENTAL CELL RESEARCH

Sec62 Protein Mediates Membrane Insertion and Orientation of Moderately Hydrophobic Signal Anchor Proteins in the Endoplasmic Reticulum (ER)

(2013) Johannes H. Reithinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Sec61/SecY-Mediated Protein Translocation Across Membranes

(2012) Eunyong Park et al.   Annual Review of Biophysics

Post-translational translocation into the endoplasmic reticulum

(2012) Nicholas Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Fluorescein Analogues Inhibit SecA ATPase: The First Sub-micromolar Inhibitor of Bacterial Protein Translocation

(2012) Ying-Ju Huang et al.   ChemMedChem

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

(2011) Craig McKibbin et al.   BIOCHEMICAL JOURNAL

Stepwise Insertion and Inversion of a Type II Signal Anchor Sequence in the Ribosome-Sec61 Translocon Complex

(2011) Prasanna K. Devaraneni et al.   CELL

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

Secretory Protein Profiling Reveals TNF-α Inactivation by Selective and Promiscuous Sec61 Modulators

(2011) Sarah V. Maifeld et al.   CHEMISTRY & BIOLOGY

Ca2+-calmodulin inhibits tail-anchored protein insertion into the mammalian endoplasmic reticulum membrane

(2011) Sarah Haßdenteufel et al.   FEBS LETTERS

Inhibition of Biosynthesis of Human Endothelin B Receptor by the Cyclodepsipeptide Cotransin

(2011) Carolin Westendorf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unsymmetrical Cyclotriazadisulfonamide (CADA) Compounds as Human CD4 Receptor Down-Modulating Agents

(2011) Violeta G. Demillo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Eeyarestatin 1 Interferes with Both Retrograde and Anterograde Intracellular Trafficking Pathways

(2011) Mina-Olga Aletrari et al.   PLoS One

Molecular Mechanism of Co-translational Protein Targeting by the Signal Recognition Particle

(2011) Ishu Saraogi et al.   TRAFFIC

Protein translocation across the ER membrane

(2010) Richard Zimmermann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

(2010) Qiuyan Wang et al.   PLoS One

Post-translational import of protein into the endoplasmic reticulum of a trypanosome: anin vitrosystem for discovery of anti-trypanosomal chemical entities

(2009) Bhargavi Patham et al.   BIOCHEMICAL JOURNAL

Functions and pathologies of BiP and its interaction partners

(2009) J. Dudek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

(2009) Y. Liu et al.   MOLECULAR PHARMACOLOGY

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life and death of a BiP substrate

(2009) Joel H. Otero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Protein Translocation Pathways across the Endoplasmic Reticulum inTrypanosoma brucei

(2008) Hanoch Goldshmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of p97-dependent Protein Degradation by Eeyarestatin I

(2008) Qiuyan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The concept of translocational regulation

(2008) Ramanujan S. Hegde et al.   JOURNAL OF CELL BIOLOGY