Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

How does Sec63 affect the conformation of Sec61 in yeast?

(2021) Pratiti Bhadra et al.   PLoS Computational Biology

Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity

(2021) Belinda S Hall et al.   Autophagy

Structure of the Inhibited State of the Sec Translocon

(2020) Samuel F. Gérard et al.   MOLECULAR CELL

Mechanism of Mycolactone Toxin Membrane Permeation: Atomistic vs Coarse-Grained MARTINI Simulations

(2019) Fikret Aydin et al.   BIOPHYSICAL JOURNAL

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

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Configurationally Stabilized Analogs of M. ulcerans Exotoxins Mycolactones A and B Reveal the Importance of Side Chain Geometry for Mycolactone Virulence

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Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses

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Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

(2018) Joy Ogbechi et al.   Cell Death & Disease

Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans

(2018) Cesar A. López et al.   PLoS Computational Biology

The potent effect of mycolactone on lipid membranes

(2018) Milène Nitenberg et al.   PLoS Pathogens

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

(2018) Caroline Demangel et al.   BIOLOGY OF THE CELL

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis

(2018) Patrick J. Chitwood et al.   CELL

Structure of the post-translational protein translocation machinery of the ER membrane

(2018) Xudong Wu et al.   NATURE

Structure of the posttranslational Sec protein-translocation channel complex from yeast

(2018) Samuel Itskanov et al.   SCIENCE

HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum

(2017) Jie Wang et al.   GENE

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Axonal Endoplasmic Reticulum Ca 2+ Content Controls Release Probability in CNS Nerve Terminals

(2017) Jaime de Juan-Sanz et al.   NEURON

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

(2017) Jeff E. Grotzke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases

(2017) Sven Lang et al.   Frontiers in Physiology

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent advances: role of mycolactone in the pathogenesis and monitoring ofMycobacterium ulceransinfection/Buruli ulcer disease

(2015) Fred Stephen Sarfo et al.   CELLULAR MICROBIOLOGY

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Shaping mycolactone for therapeutic use against inflammatory disorders

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Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

(2015) Joy Ogbechi et al.   PLoS Pathogens

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

Synthetic Variants of Mycolactone Bind and Activate Wiskott–Aldrich Syndrome Proteins

(2014) Anne-Caroline Chany et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

(2014) Richard O. Phillips et al.   PLoS Neglected Tropical Diseases

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

(2013) Laure Guenin-Macé et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans

(2013) Nicole Scherr et al.   PLoS Neglected Tropical Diseases

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

Sec61 complexes form ubiquitous ER Ca2+leak channels

(2011) Sven Lang et al.   Channels

A Diverted Total Synthesis of Mycolactone Analogues: An Insight into Buruli Ulcer Toxins

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PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Preserving the membrane barrier for small molecules during bacterial protein translocation

(2011) Eunyong Park et al.   NATURE

Chemistry of mycolactones, the causative toxins of Buruli ulcer

(2011) Y. Kishi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organellar Calcium Buffers

(2011) D. Prins et al.   Cold Spring Harbor Perspectives in Biology

Interaction of calmodulin with Sec61α limits Ca2+leakage from the endoplasmic reticulum

(2010) Frank Erdmann et al.   EMBO JOURNAL

Sec61β, a subunit of the Sec61 protein translocation channel at the Endoplasmic Reticulum, is involved in the transport of Gurken to the plasma membrane.

(2009) Anshuman Kelkar et al.   BMC CELL BIOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

(2009) Caroline Demangel et al.   NATURE REVIEWS MICROBIOLOGY