Mycolactone induces cell death by SETD1B-dependent degradation of glutathione

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

(2018) Jean-David Morel et al.   MOLECULAR & CELLULAR PROTEOMICS

CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity

(2018) Nicholas J. Kramer et al.   NATURE GENETICS

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

(2018) Joy Ogbechi et al.   Cell Death & Disease

HaSAPPy: A tool for candidate identification in pooled forward genetic screens of haploid mammalian cells

(2018) Giulio Di Minin et al.   PLoS Computational Biology

The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

(2018) Kerstin Schmidt et al.   eLife

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

(2018) Caroline Demangel et al.   BIOLOGY OF THE CELL

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis

(2017) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

(2017) Inge M.N. Wortel et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2α-ATF4 pathway

(2017) Meng-Shian Chen et al.   Oncotarget

Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

(2016) Michael McKenna et al.   JOURNAL OF CELL SCIENCE

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

(2016) Ludivine Baron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CLIC1 Inhibition Attenuates Vascular Inflammation, Oxidative Stress, and Endothelial Injury

(2016) Yingling Xu et al.   PLoS One

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation

(2014) A. S. Bledau et al.   DEVELOPMENT

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

A Dual Role for SAGA-Associated Factor 29 (SGF29) in ER Stress Survival by Coordination of Both Histone H3 Acetylation and Histone H3 Lysine-4 Trimethylation

(2013) Andrea W. Schram et al.   PLoS One

Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione

(2012) Akhilesh Kumar et al.   EMBO REPORTS

MLL1, a H3K4 methyltransferase, regulates the TNFα-stimulated activation of genes downstream of NF-κB

(2012) Xiang Wang et al.   JOURNAL OF CELL SCIENCE

Chloride intracellular channel 1 (CLIC1): Sensor and effector during oxidative stress

(2010) Stefania Averaimo et al.   FEBS LETTERS

Antioxidants Protect Keratinocytes against M. ulcerans Mycolactone Cytotoxicity

(2010) Alvar Grönberg et al.   PLoS One

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY