The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

Pleiotropic molecular effects of theMycobacterium ulceransvirulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer

(2014) Belinda Hall et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

(2013) Laure Guenin-Macé et al.   JOURNAL OF CLINICAL INVESTIGATION

Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

(2013) Deepak V. Almeida et al.   PLoS Neglected Tropical Diseases

Microbiological, Histological, Immunological, and Toxin Response to Antibiotic Treatment in the Mouse Model of Mycobacterium ulcerans Disease

(2013) Fred Stephen Sarfo et al.   PLoS Neglected Tropical Diseases

Local and Regional Re-Establishment of Cellular Immunity during Curative Antibiotherapy of Murine Mycobacterium ulcerans Infection

(2012) Teresa G. Martins et al.   PLoS One

Cell Elasticity Determines Macrophage Function

(2012) Naimish R. Patel et al.   PLoS One

Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection

(2012) Teresa G. Martins et al.   PLoS Neglected Tropical Diseases

Effect of Rifampin on Production of Inflammatory Mediators in HepG2 Liver Epithelial Cells

(2011) Yael Yuhas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response

(2011) Craig McKibbin et al.   BIOCHEMICAL JOURNAL

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes

(2011) Nicholas T. Ingolia et al.   CELL

Paradoxical Responses After Start of Antimicrobial Treatment in Mycobacterium ulcerans Infection

(2011) W. A. Nienhuis et al.   CLINICAL INFECTIOUS DISEASES

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

(2011) L. Guenin-Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

Chemical and Pharmacological Chaperones: Application for Recombinant Protein Production and Protein Folding Diseases

(2010) Rahul S. Rajan et al.   CURRENT MEDICINAL CHEMISTRY

MycobacteriumulceransTriggers T-Cell Immunity followed by Local and Regional but Not Systemic Immunosuppression

(2010) Alexandra G. Fraga et al.   INFECTION AND IMMUNITY

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group

(2010) Qiuyan Wang et al.   PLoS One

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes

(2009) I. R. Powley et al.   GENES & DEVELOPMENT

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Biogenesis of tail-anchored proteins: the beginning for the end?

(2009) C. Rabu et al.   JOURNAL OF CELL SCIENCE

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

Immunosuppressive Signature of CutaneousMycobacterium ulceransInfection in the Peripheral Blood of Patients with Buruli Ulcer Disease

(2009) Richard Phillips et al.   JOURNAL OF INFECTIOUS DISEASES

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

(2009) Y. Liu et al.   MOLECULAR PHARMACOLOGY

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

(2009) Caroline Demangel et al.   NATURE REVIEWS MICROBIOLOGY

Post-transcriptional control of cytokine production

(2008) Paul Anderson   NATURE IMMUNOLOGY

Signalling, inflammation and arthritis: NF- B and its relevance to arthritis and inflammation

(2008) R. E. Simmonds et al.   RHEUMATOLOGY

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

(2008) Hui Hong et al.   PLoS Neglected Tropical Diseases