Mechanistic insights into the inhibition of Sec61-dependent co- and post-translational translocation by mycolactone

Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon

(2015) T. Junne et al.   JOURNAL OF CELL SCIENCE

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Inhibitors of Protein Translocation Across the ER Membrane

(2015) Kai-Uwe Kalies et al.   TRAFFIC

Structure of the native Sec61 protein-conducting channel

(2015) Stefan Pfeffer et al.   Nature Communications

Mammalian SRP receptor switches the Sec61 translocase from Sec62 to SRP-dependent translocation

(2015) Bhalchandra Jadhav et al.   Nature Communications

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

(2015) Joy Ogbechi et al.   PLoS Pathogens

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Mycobacterial Toxin Induces Analgesia in Buruli Ulcer by Targeting the Angiotensin Pathways

(2014) Estelle Marion et al.   CELL

Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion

(2014) Marko Gogala et al.   NATURE

Cotranslational folding inhibits translocation from within the ribosome–Sec61 translocon complex

(2014) Brian J Conti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling

(2014) C. H. Jan et al.   SCIENCE

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER

(2014) Belinda S. Hall et al.   PLoS Pathogens

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate

(2014) Andrew L MacKinnon et al.   eLife

Co-translational targeting and translocation of proteins to the endoplasmic reticulum

(2013) Yvonne Nyathi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

(2013) Laure Guenin-Macé et al.   JOURNAL OF CLINICAL INVESTIGATION

The Signal Sequence Influences Post-Translational ER Translocation at Distinct Stages

(2013) Nicholas Johnson et al.   PLoS One

Post-translational translocation into the endoplasmic reticulum

(2012) Nicholas Johnson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

BiP-mediated closing of the Sec61 channel limits Ca2+leakage from the ER

(2012) Nico Schäuble et al.   EMBO JOURNAL

A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function

(2012) Steven F. Trueman et al.   JOURNAL OF CELL BIOLOGY

Different effects of Sec61 , Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

(2012) S. Lang et al.   JOURNAL OF CELL SCIENCE

TRC40 can deliver short secretory proteins to the Sec61 translocon

(2012) N. Johnson et al.   JOURNAL OF CELL SCIENCE

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

(2012) Asvin K. K. Lakkaraju et al.   MOLECULAR BIOLOGY OF THE CELL

A Calmodulin-Dependent Translocation Pathway for Small Secretory Proteins

(2011) Sichen Shao et al.   CELL

Secretory Protein Profiling Reveals TNF-α Inactivation by Selective and Promiscuous Sec61 Modulators

(2011) Sarah V. Maifeld et al.   CHEMISTRY & BIOLOGY

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Buruli Ulcer: Advances in Understanding Mycobacterium ulcerans Infection

(2010) Douglas S. Walsh et al.   DERMATOLOGIC CLINICS

Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein

(2010) C. Mary et al.   RNA

Eeyarestatin I inhibits Sec61-mediated protein translocation at the endoplasmic reticulum

(2009) B. C. S. Cross et al.   JOURNAL OF CELL SCIENCE

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

(2009) S. Boulkroun et al.   JOURNAL OF IMMUNOLOGY

Mycolactone Inhibits Monocyte Cytokine Production by a Posttranscriptional Mechanism

(2009) R. E. Simmonds et al.   JOURNAL OF IMMUNOLOGY

Pathogenetic mechanisms of the intracellular parasite Mycobacterium ulcerans leading to Buruli ulcer

(2009) Manuel T Silva et al.   LANCET INFECTIOUS DISEASES

Oxidoreductase activity of oligosaccharyltransferase subunits Ost3p and Ost6p defines site-specific glycosylation efficiency

(2009) B. L. Schulz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

A Precursor-specific Role for Hsp40/Hsc70 during Tail-anchored Protein Integration at the Endoplasmic Reticulum

(2008) Catherine Rabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY