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Title
Topoisomerase-Mediated DNA Damage in Neurological Disorders
Authors
Keywords
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Journal
Frontiers in Aging Neuroscience
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-12-01
DOI
10.3389/fnagi.2021.751742
References
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Note: Only part of the references are listed.- Gene Size Matters: An Analysis of Gene Length in the Human Genome
- (2021) Inês Lopes et al. Frontiers in Genetics
- Profiling DNA break sites and transcriptional changes in response to contextual fear learning
- (2021) Ryan T. Stott et al. PLoS One
- Structural basis for allosteric regulation of Human Topoisomerase IIα
- (2021) Arnaud Vanden Broeck et al. Nature Communications
- The role of single strand break repair pathways in cellular responses to camptothecin induced DNA damage
- (2020) Chao Mei et al. BIOMEDICINE & PHARMACOTHERAPY
- Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
- (2020) Lien D Nguyen et al. EMBO Molecular Medicine
- Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression
- (2020) Jonathan A. Beagan et al. NATURE NEUROSCIENCE
- Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2
- (2020) Matthew J Schellenberg et al. NUCLEIC ACIDS RESEARCH
- Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration
- (2020) Giulia Fragola et al. Nature Communications
- Characterization of a novel loss-of-function variant in TDP2 in two adult patients with spinocerebellar ataxia autosomal recessive 23 (SCAR23)
- (2020) Edoardo Errichiello et al. JOURNAL OF HUMAN GENETICS
- Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
- (2020) Ilona Kalasova et al. NUCLEIC ACIDS RESEARCH
- Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases
- (2020) Guido Zagnoli-Vieira et al. DNA REPAIR
- Ataxia‐telangiectasia: A review of clinical features and molecular pathology
- (2019) Parisa Amirifar et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain
- (2019) Sara Emad El-Agamy et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Mapping the transcriptional diversity of genetically and anatomically defined cell populations in the mouse brain
- (2019) Ken Sugino et al. eLife
- DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms
- (2019) Arwa A. Abugable et al. DNA REPAIR
- Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
- (2019) Andres Canela et al. MOLECULAR CELL
- Chemotherapy-induced cognitive impairments: A systematic review of the animal literature
- (2019) A. Matsos et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
- (2019) Vinod Tiwari et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Consolidating the Role of TDP2 Mutations in Recessive Spinocerebellar Ataxia Associated with Pediatric Onset Drug Resistant Epilepsy and Intellectual Disability (SCAR23)
- (2019) Claudia Ciaccio et al. CEREBELLUM
- DNA double-strand breaks: a potential therapeutic target for neurodegenerative diseases
- (2019) Nidheesh Thadathil et al. CHROMOSOME RESEARCH
- A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome
- (2019) William H. Gittens et al. Nature Communications
- Tyrosyl-DNA Phosphodiesterase I N-Terminal Domain Modifications and Interactions Regulate Cellular Function
- (2019) Brettrager et al. Genes
- DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?
- (2018) Camilla Björkegren et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Roles of DNA Topoisomerase IIβ in Transcription
- (2018) Ram Madabhushi INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes
- (2018) Ka Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Emerging themes in neuronal activity-dependent gene expression
- (2018) Ram Madabhushi et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Structural basis for DNA 3′-end processing by human tyrosyl-DNA phosphodiesterase 1
- (2018) Fiona J. Flett et al. Nature Communications
- DNA double-strand breaks as drivers of neural genomic change, function, and disease
- (2018) Frederick W. Alt et al. DNA REPAIR
- Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior
- (2018) Ee-Lynn Yap et al. NEURON
- Neuronal activity modifies the chromatin accessibility landscape in the adult brain
- (2017) Yijing Su et al. NATURE NEUROSCIENCE
- ZATT (ZNF451)–mediated resolution of topoisomerase 2 DNA-protein cross-links
- (2017) Matthew J. Schellenberg et al. SCIENCE
- RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription
- (2016) Laura Baranello et al. CELL
- Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells
- (2016) Pei-Chi Wei et al. CELL
- Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes
- (2016) Nguyen Ngoc Hoa et al. MOLECULAR CELL
- Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts
- (2016) Rajashree A. Deshpande et al. MOLECULAR CELL
- Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
- (2016) W. P. Vermeij et al. NATURE
- XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
- (2016) Nicolas C. Hoch et al. NATURE
- Roles of eukaryotic topoisomerases in transcription, replication and genomic stability
- (2016) Yves Pommier et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Topoisomerases and the regulation of neural function
- (2016) Peter J. McKinnon NATURE REVIEWS NEUROSCIENCE
- Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage
- (2016) Timsi Rao et al. NUCLEIC ACIDS RESEARCH
- Reversal of DNA damage induced Topoisomerase 2 DNA–protein crosslinks by Tdp2
- (2016) Matthew J. Schellenberg et al. NUCLEIC ACIDS RESEARCH
- Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin
- (2016) Selma M. Cuya et al. Oncotarget
- The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease
- (2016) Laura Narciso et al. NEURAL PLASTICITY
- Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms
- (2016) Angela M. Mabb et al. PLoS One
- Repair synthesis step involving ERCC1-XPF participates in DNA repair of the Top1-DNA damage complex
- (2015) Chiaki Takahata et al. CARCINOGENESIS
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- (2015) Janusz Puc et al. CELL
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- (2015) Ram Madabhushi et al. CELL
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- (2015) Kevin W. Trotter et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2015) Harrison W. Gabel et al. NATURE
- Gene Length Matters in Neurons
- (2015) Mark J. Zylka et al. NEURON
- Transcriptional elongation requires DNA break-induced signalling
- (2015) Heeyoun Bunch et al. Nature Communications
- Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
- (2015) Pierre Caron et al. Cell Reports
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- (2014) Evan Q. Comeaux et al. DRUG METABOLISM REVIEWS
- Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)
- (2014) Rui Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP2 keeps the brain healthy
- (2014) Peter J McKinnon NATURE GENETICS
- TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function
- (2014) Fernando Gómez-Herreros et al. NATURE GENETICS
- Genome-wide identification and characterization of functional neuronal activity–dependent enhancers
- (2014) Athar N Malik et al. NATURE NEUROSCIENCE
- Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes
- (2014) Sachin Katyal et al. NATURE NEUROSCIENCE
- DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors
- (2014) Edward C. Gilmore NEUROGENETICS
- DNA Damage and Its Links to Neurodegeneration
- (2014) Ram Madabhushi et al. NEURON
- PARP1–TDP1 coupling for the repair of topoisomerase I–induced DNA damage
- (2014) Benu Brata Das et al. NUCLEIC ACIDS RESEARCH
- ATM Deficiency Results in Accumulation of DNA-Topoisomerase I Covalent Intermediates in Neural Cells
- (2014) Meryem Alagoz et al. PLoS One
- Cognitive impact of cytotoxic agents in mice
- (2014) R. Seigers et al. PSYCHOPHARMACOLOGY
- ATM specifically mediates repair of double-strand breaks with blocked DNA ends
- (2014) Alejandro Álvarez-Quilón et al. Nature Communications
- DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
- (2013) Atsushi Shibata et al. MOLECULAR CELL
- Topoisomerases facilitate transcription of long genes linked to autism
- (2013) Ian F. King et al. NATURE
- Activity-dependent neuronal signalling and autism spectrum disorder
- (2013) Daniel H. Ebert et al. NATURE
- Maintaining genome stability in the nervous system
- (2013) Peter J McKinnon NATURE NEUROSCIENCE
- Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β
- (2013) Elsa Suberbielle et al. NATURE NEUROSCIENCE
- TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo
- (2013) Fernando Gómez-Herreros et al. PLoS Genetics
- The importance of being supercoiled: How DNA mechanics regulate dynamic processes
- (2012) Laura Baranello et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Biochemical Characterization of Human Tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP)
- (2012) Rui Gao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
- (2012) Junko Murai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2
- (2012) Matthew J Schellenberg et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2
- (2012) Ke Shi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1
- (2012) Zhihong Zeng et al. NUCLEIC ACIDS RESEARCH
- Target genes of Topoisomerase II regulate neuronal survival and are defined by their chromatin state
- (2012) V. K. Tiwari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair
- (2012) Jessica J.R. Hudson et al. Nature Communications
- MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA
- (2012) K. C. Lee et al. Biology Open
- ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
- (2011) Peter J. McKinnon Annual Review of Pathology-Mechanisms of Disease
- Pleiotropic functions of EAPII/TTRAP/TDP2
- (2011) Chunyang Li et al. CELL CYCLE
- DNA Repair Factor MRE11/RAD50 Cleaves 3′-Phosphotyrosyl Bonds and Resects DNA to Repair Damage Caused by Topoisomerase 1 Poisons
- (2011) Elizabeth J. Sacho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- All tangled up: how cells direct, manage and exploit topoisomerase function
- (2011) Seychelle M. Vos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
- (2011) Yong-Wei Zhang et al. NUCLEIC ACIDS RESEARCH
- Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function
- (2011) A. E. West et al. Cold Spring Harbor Perspectives in Biology
- TDP1 serine 81 promotes interaction with DNA ligase IIIα and facilitates cell survival following DNA damage
- (2010) Shih-Chieh Chiang et al. CELL CYCLE
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
- (2010) Yves Pommier et al. CHEMISTRY & BIOLOGY
- TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
- (2010) Zhihong Zeng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity
- (2010) Hyunju Ryu et al. JOURNAL OF CELL BIOLOGY
- Widespread transcription at neuronal activity-regulated enhancers
- (2010) Tae-Kyung Kim et al. NATURE
- Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
- (2010) Michael C Haffner et al. NATURE GENETICS
- A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin
- (2009) Roger H.F. Wong et al. CELL
- In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation
- (2009) Amy J. Hawkins et al. DNA REPAIR
- Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin
- (2009) Sherif F. El-Khamisy et al. DNA REPAIR
- Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks
- (2009) Tong Zhou et al. DNA REPAIR
- Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK
- (2009) Benu Brata Das et al. EMBO JOURNAL
- Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks
- (2009) Olivier Sordet et al. EMBO REPORTS
- Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
- (2009) Janelle L. Harris et al. HUMAN MOLECULAR GENETICS
- Transcriptional and Electrophysiological Maturation of Neocortical Fast-Spiking GABAergic Interneurons
- (2009) B. W. Okaty et al. JOURNAL OF NEUROSCIENCE
- A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage
- (2009) Felipe Cortes Ledesma et al. NATURE
- The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1
- (2009) Youngsoo Lee et al. NATURE NEUROSCIENCE
- A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes
- (2008) Chao-Po Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1
- (2008) J. J. Reynolds et al. MOLECULAR AND CELLULAR BIOLOGY
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