Topoisomerases facilitate transcription of long genes linked to autism

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

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Progress toward treatments for synaptic defects in autism

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From neural development to cognition: unexpected roles for chromatin

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Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures

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Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

The importance of being supercoiled: How DNA mechanics regulate dynamic processes

(2012) Laura Baranello et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Cellular and synaptic network defects in autism

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Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a

(2012) Linyan Meng et al.   HUMAN MOLECULAR GENETICS

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

De Novo Gene Disruptions in Children on the Autistic Spectrum

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Target genes of Topoisomerase II  regulate neuronal survival and are defined by their chromatin state

(2012) V. K. Tiwari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

(2011) Hsien-Sung Huang et al.   NATURE

The conundrums of understanding genetic risks for autism spectrum disorders

(2011) Matthew W State et al.   NATURE NEUROSCIENCE

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2

(2011) Julia L. MacIsaac et al.   NUCLEIC ACIDS RESEARCH

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

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c-Myc Regulates Transcriptional Pause Release

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Induced pluripotent stem cell models of the genomic imprinting disorders Angelman and Prader–Willi syndromes

(2010) Stormy J. Chamberlain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of drug mode of action and drug repositioning from transcriptional responses

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The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

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Global Survey of Genomic Imprinting by Transcriptome Sequencing

(2008) Tomas Babak et al.   CURRENT BIOLOGY

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

AutDB: a gene reference resource for autism research

(2008) Saumyendra N. Basu et al.   NUCLEIC ACIDS RESEARCH

Topoisomerase IIβ Activates a Subset of Neuronal Genes that Are Repressed in AT-Rich Genomic Environment

(2008) Kuniaki Sano et al.   PLoS One