Biochemical Characterization of Human Tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP)

Tyrosyl-DNA Phosphodiesterase as a Target for Anticancer Therapy

(2012) Thomas Dexheimer et al.   Anti-Cancer Agents in Medicinal Chemistry

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells

(2012) Junko Murai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erratum: Interfacial inhibitors: targeting macromolecular complexes

(2012) Yves Pommier et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a novel assay for human tyrosyl DNA phosphodiesterase 2

(2011) Sanjay Adhikari et al.   ANALYTICAL BIOCHEMISTRY

The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition

(2011) S Vilotti et al.   CELL DEATH AND DIFFERENTIATION

Characterization of the Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1

(2011) Wan-Cheol Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Oncogenic role of EAPII in lung cancer development and its activation of the MAPK–ERK pathway

(2011) C Li et al.   ONCOGENE

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

The DNA binding and 3′-end preferential activity of human tyrosyl-DNA phosphodiesterase

(2010) Thomas S. Dexheimer et al.   NUCLEIC ACIDS RESEARCH

Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration

(2009) Jian-qi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

TTRAP is a novel PML nuclear bodies-associated protein

(2008) Guan-lan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA-topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts

(2008) T. S. Dexheimer et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS