All tangled up: how cells direct, manage and exploit topoisomerase function

Chromosome length influences replication-induced topological stress

(2011) Andreas Kegel et al.   NATURE

Replication and segregation of an Escherichia coli chromosome with two replication origins

(2011) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive Supercoiling of Mitotic DNA Drives Decatenation by Topoisomerase II in Eukaryotes

(2011) J. Baxter et al.   SCIENCE

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

(2011) N. Kim et al.   SCIENCE

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative Damage

(2010) Jing Ye et al.   CELL

FtsK DNA Translocase: The Fast Motor That Knows Where It's Going

(2010) Estelle Crozat et al.   CHEMBIOCHEM

Topoisomerase I regulates open chromatin and controls gene expression in vivo

(2010) Mickaël Durand-Dubief et al.   EMBO JOURNAL

Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death

(2010) X. Wang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIASy-dependent SUMOylation regulates DNA topoisomerase IIα activity

(2010) Hyunju Ryu et al.   JOURNAL OF CELL BIOLOGY

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

(2010) Hengyao Niu et al.   NATURE

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

(2010) Petr Cejka et al.   NATURE

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

DNA chirality-dependent stimulation of topoisomerase IV activity by the C-terminal AAA+ domain of FtsK

(2010) Sarah Bigot et al.   NUCLEIC ACIDS RESEARCH

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

(2010) M. J. Lippert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

(2010) T. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A naturally chimeric type IIA topoisomerase in Aquifex aeolicus highlights an evolutionary path for the emergence of functional paralogs

(2010) E. M. Tretter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction

(2010) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical and functional interaction between the condensin MukB and the decatenase topoisomerase IV in Escherichia coli

(2010) R. Hayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meiotic Recombination Provokes Functional Activation of the p53 Regulatory Network

(2010) W.-J. Lu et al.   SCIENCE

Crystal Structure of a Bacterial Topoisomerase IB in Complex with DNA Reveals a Secondary DNA Binding Site

(2010) Asmita Patel et al.   STRUCTURE

The SR Protein B52/SRp55 Is Required for DNA Topoisomerase I Recruitment to Chromatin, mRNA Release and Transcription Shutdown

(2010) François Juge et al.   PLoS Genetics

Reverse gyrase and genome stability in hyperthermophilic organisms

(2009) Giuseppe Perugino et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coordinating the Two Protomer Active Sites of Human Topoisomerase IIα: Nicks as Topoisomerase II Poisons†

(2009) Joseph E. Deweese et al.   BIOCHEMISTRY

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks

(2009) Chao-Po Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ctp1CtIP and Rad32Mre11 Nuclease Activity Are Required for Rec12Spo11 Removal, but Rec12Spo11 Removal Is Dispensable for Other MRN-Dependent Meiotic Functions

(2009) E. Hartsuiker et al.   MOLECULAR AND CELLULAR BIOLOGY

Actin Homolog MreB Affects Chromosome Segregation by Regulating Topoisomerase IV in Escherichia coli

(2009) Ram Madabhushi et al.   MOLECULAR CELL

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY

Transient dsDNA breaks during pre-replication complex assembly

(2009) Emmanouil Rampakakis et al.   NUCLEIC ACIDS RESEARCH

Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA

(2009) Ilaria Dalla Rosa et al.   NUCLEIC ACIDS RESEARCH

A Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8, Bound to DNA Gyrase

(2009) M. J. Edwards et al.   SCIENCE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Mitochondrial Topoisomerase I Sites in the Regulatory D-Loop Region of Mitochondrial DNA†

(2008) Hongliang Zhang et al.   BIOCHEMISTRY

Resolution of Sister Centromeres Requires RanBP2-Mediated SUMOylation of Topoisomerase IIα

(2008) Meelad M. Dawlaty et al.   CELL

The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes

(2008) Martijn S. Luijsterburg et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

(2008) T. R. Singh et al.   GENES & DEVELOPMENT

RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability

(2008) D. Xu et al.   GENES & DEVELOPMENT

Poly(ADP-ribose) Binds to the Splicing Factor ASF/SF2 and Regulates Its Phosphorylation by DNA Topoisomerase I

(2008) Maria Malanga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plk1-dependent Phosphorylation Regulates Functions of DNA Topoisomerase IIα in Cell Cycle Progression

(2008) Hongchang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Transcription Regulation by DNA Topoisomerase I in Exponentially Growing Saccharomyces cerevisiae Cells: Activation of Telomere-Proximal Genes by TOP1 Deletion

(2008) Luca Lotito et al.   JOURNAL OF MOLECULAR BIOLOGY

Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I

(2008) Olivier Sordet et al.   JOURNAL OF MOLECULAR BIOLOGY

Asp-to-Asn Substitution at the First Position of the DxD TOPRIM Motif of Recombinant Bacterial Topoisomerase I Is Extremely Lethal to E. coli

(2008) Bokun Cheng et al.   JOURNAL OF MOLECULAR BIOLOGY

Topoisomerase II  Negatively Modulates Retinoic Acid Receptor   Function: a Novel Mechanism of Retinoic Acid Resistance

(2008) S. McNamara et al.   MOLECULAR AND CELLULAR BIOLOGY

Resolution of Converging Replication Forks by RecQ and Topoisomerase III

(2008) Catherine Suski et al.   MOLECULAR CELL

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL

DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

(2008) Allyn J. Schoeffler et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Dual Role of Topoisomerase II in Centromere Resolution and Aurora B Activity

(2008) Paula A Coelho et al.   PLOS BIOLOGY