The Roles of Neutrophils in Cytokine Storms

Patients With Chronic Hepatitis C Virus Infection Are at an Increased Risk of Colorectal Cancer: A Nationwide Population-Based Case-Control Study in Taiwan

(2021) Fu-Hsiung Su et al.   Frontiers in Oncology

A neutrophil activation signature predicts critical illness and mortality in COVID-19

(2021) Matthew L. Meizlish et al.   Blood Advances

Cancer Risk in Patients With Biopsy‐Confirmed Nonalcoholic Fatty Liver Disease: A Population‐Based Cohort Study

(2021) Tracey G. Simon et al.   HEPATOLOGY

Neutrophils in respiratory viral infections

(2021) Cecilia Johansson et al.   Mucosal Immunology

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

(2021) Lina Ma et al.   Science Immunology

Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target

(2021) Dakai Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CAR T-Cells for CNS Lymphoma: Driving into New Terrain?

(2021) Philipp Karschnia et al.   Cancers

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock

(2020) Emeka B. Okeke et al.   BIOMATERIALS

Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients

(2020) Zhuo Zhou et al.   Cell Host & Microbe

Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases

(2020) Renato G. S. Chirivi et al.   Cellular & Molecular Immunology

Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19

(2020) Yuwei Liu et al.   JOURNAL OF INFECTION

Neutrophils at the crossroads of innate and adaptive immunity

(2020) Carlos Rosales   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage

(2020) Jingyuan Liu et al.   Journal of Translational Medicine

Epigenetic remodelling shapes inflammatory renal cancer and neutrophil-dependent metastasis

(2020) Jun Nishida et al.   NATURE CELL BIOLOGY

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

(2020) Kurt A. Schalper et al.   NATURE MEDICINE

O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5

(2020) Qiming Wang et al.   Science Advances

Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome

(2020) Elizabeth A Middleton et al.   BLOOD

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

(2020) Victoria Mutua et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients

(2020) Ai-Ping Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophil to CD4+ lymphocyte ratio as a potential biomarker in predicting virus negative conversion time in COVID-19

(2020) Haizhou Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

(2020) Mirre De Bondt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential Peptidoglycan Recognition Assay Using Varied Surface Presentations

(2020) Elizabeth A. D’Ambrosio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection

(2020) Vijendra Ramlall et al.   NATURE MEDICINE

Neutrophil-to-Lymphocyte Ratio and Outcomes in Louisiana Covid-19 Patients

(2020) Danielle Tatum et al.   SHOCK

The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China

(2020) Jianhong Fu et al.   THROMBOSIS RESEARCH

Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

(2020) Netanel Karbian et al.   Cell Death & Disease

Neutrophils, Crucial, or Harmful Immune Cells Involved in Coronavirus Infection: A Bioinformatics Study

(2020) Nima Hemmat et al.   Frontiers in Genetics

COVID-19 Hyperinflammation: What about Neutrophils?

(2020) Athanasios Didangelos   mSphere

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Hematopoietic recovery in patients receiving chimeric antigen receptor T-cell therapy for hematologic malignancies

(2020) Tania Jain et al.   Blood Advances

A meta‐analysis of SARS‐CoV‐2 patients identifies the combinatorial significance of D‐dimer, C‐reactive protein, lymphocyte, and neutrophil values as a predictor of disease severity

(2020) Kunwar Singh et al.   International Journal of Laboratory Hematology

Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

(2020) Panagiotis Skendros et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology

(2020) Flavio Protasio Veras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

(2020) Jan C. Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Blockade of TNFR1 Improves Clinical Disease and Bronchoconstriction in Experimental RSV Infection

(2020) Dorothea R. Morris et al.   Viruses-Basel

Disharmonic Inflammatory Signatures in COVID-19: Augmented Neutrophils’ but Impaired Monocytes’ and Dendritic Cells’ Responsiveness

(2020) Zuzana Parackova et al.   Cells

Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

(2020) Meghan A. Cupp et al.   BMC Medicine

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased age, neutrophil-to-lymphocyte ratio (NLR) and white blood cells count are associated with higher COVID-19 mortality

(2020) Elnaz Vafadar Moradi et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Neutrophil–macrophage cooperation and its impact on tissue repair

(2019) Tiffany Bouchery et al.   IMMUNOLOGY AND CELL BIOLOGY

Neutrophil plasticity in the tumor microenvironment

(2019) Morgan Giese et al.   BLOOD

Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2

(2019) Carmelo Carmona-Rivera et al.   BLOOD

Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines

(2019) Marco Antonio Cassatella et al.   TRENDS IN IMMUNOLOGY

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Neutrophil Diversity in Health and Disease

(2019) Carlos Silvestre-Roig et al.   TRENDS IN IMMUNOLOGY

Neutrophils in innate immunity and systems biology‐level approaches

(2019) Viktoria Rungelrath et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Innate Immune Response to Influenza Virus at Single-Cell Resolution in Human Epithelial Cells Revealed Paracrine Induction of Interferon Lambda 1

(2019) Irene Ramos et al.   JOURNAL OF VIROLOGY

Dysbiosis of Gram‑negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type�2 diabetic patients with chronic kidney disease

(2019) Maria Salguero et al.   Experimental and Therapeutic Medicine

Neutrophils—Important Communicators in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

(2019) Lina Wirestam et al.   Frontiers in Immunology

Partners in crime: neutrophils and monocytes/macrophages in inflammation and disease

(2018) Kathryn Prame Kumar et al.   CELL AND TISSUE RESEARCH

Neutrophils in viral infection

(2018) Victor Naumenko et al.   CELL AND TISSUE RESEARCH

Cytokine production by human neutrophils: Revisiting the “dark side of the moon”

(2018) Nicola Tamassia et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

(2018) Liuluan Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

Staphylococcus aureusbiofilms release leukocidins to elicit extracellular trap formation and evade neutrophil-mediated killing

(2018) Mohini Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

(2018) Carlos Rosales   Frontiers in Physiology

Differential Ability of Pandemic and Seasonal H1N1 Influenza A Viruses To Alter the Function of Human Neutrophils

(2018) Natalia Malachowa et al.   mSphere

Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy

(2018) Noelle Frey et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

ASBMT Consensus Grading for Cytokine Release Syndrome and Neurological Toxicity Associated with Immune Effector Cells

(2018) Daniel W Lee et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Interleukin 8 targeted contrast echocardiography is effective to evaluate myocardial ischemia-reperfusion injury in the rabbits

(2018) Yue Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

(2018) WonJae Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Missing in action-The meaning of cell death in tissue damage and inflammation

(2017) Luis E. Muñoz et al.   IMMUNOLOGICAL REVIEWS

Targeting Neutrophilic Inflammation Using Polymersome-Mediated Cellular Delivery

(2017) James D. Robertson et al.   JOURNAL OF IMMUNOLOGY

Cytokine Imbalance as a Common Mechanism in Both Psoriasis and Rheumatoid Arthritis

(2017) Yong Tan et al.   MEDIATORS OF INFLAMMATION

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Cytokine storms in infectious diseases

(2017) John R. Teijaro   Seminars in Immunopathology

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

(2016) Stephanie Volmering et al.   IMMUNITY

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

(2016) Ian K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

(2016) D. T. Teachey et al.   Cancer Discovery

Neutrophil/Lymphocyte Ratio in Patients with Rheumatoid Arthritis Treated with Biological Agents

(2016) Masahito Koiwa et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

How Neutrophil Extracellular Traps Become Visible

(2016) Nicole de Buhr et al.   Journal of Immunology Research

Respiratory Mucosal Proteome Quantification in Human Influenza Infections

(2016) Tony Marion et al.   PLoS One

Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

(2016) Chan-Ki Min et al.   Scientific Reports

Neutrophil- and Platelet-to-Lymphocyte Ratios are Correlated with Disease Activity in Rheumatoid Arthritis

(2015) Haitao Fu et al.   Clinical Laboratory

Arginine-rich histones have strong antiviral activity for influenza A viruses

(2015) Marloes Hoeksema et al.   Innate Immunity

The clinical significance of the neutrophil-to-lymphocyte ratio in multiple sclerosis

(2015) Seden Demirci et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis

(2015) Ridvan Mercan et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses

(2015) Shweta Tripathi et al.   PLoS One

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

Respiratory Syncytial Virus Fusion Protein Promotes TLR-4–Dependent Neutrophil Extracellular Trap Formation by Human Neutrophils

(2015) Giselle A. Funchal et al.   PLoS One

G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration

(2014) K T Morris et al.   BRITISH JOURNAL OF CANCER

Neutrophils recruit regulatory T-cells into tumorsviasecretion of CCL17-A new mechanism of impaired antitumor immunity

(2014) Inbal Mishalian et al.   INTERNATIONAL JOURNAL OF CANCER

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Molecular Analysis of Serum and Bronchoalveolar Lavage in a Mouse Model of Influenza Reveals Markers of Disease Severity That Can Be Clinically Useful in Humans

(2014) Yadunanda Kumar et al.   PLoS One

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits

(2013) Fatma Berri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pneumococcal immune evasion: ZmpC inhibits neutrophil influx

(2013) Bas G. J. Surewaard et al.   CELLULAR MICROBIOLOGY

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Pathogenesis of influenza-induced acute respiratory distress syndrome

(2013) Kirsty R Short et al.   LANCET INFECTIOUS DISEASES

Myeloid cells as effector cells for monoclonal antibody therapy of cancer

(2013) Rens Braster et al.   METHODS

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pattern recognition receptor function in neutrophils

(2013) Christina J. Thomas et al.   TRENDS IN IMMUNOLOGY

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

The role of neutrophils in autoimmune diseases

(2012) Tamás Németh et al.   IMMUNOLOGY LETTERS

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

(2012) Linda M. Bradley et al.   PLoS Pathogens

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Hemophagocytosis causes a consumptive anemia of inflammation

(2011) Erin E. Zoller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils in multiple sclerosis are characterized by a primed phenotype

(2011) Matthias Naegele et al.   JOURNAL OF NEUROIMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Neutrophils in the pathogenesis and manifestations of SLE

(2011) Mariana J. Kaplan   Nature Reviews Rheumatology

The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice

(2011) Michelle D. Tate et al.   PLoS One

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37

(2011) Peter G. Barlow et al.   PLoS One

Neutrophils in rheumatoid arthritis: More than simple final effectors

(2010) R. Cascão et al.   AUTOIMMUNITY REVIEWS

Extensive infiltration of neutrophils in the acute phase of experimental autoimmune encephalomyelitis in C57BL/6 mice

(2010) Fenglan Wu et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory Arthritis

(2010) Richard C. Chou et al.   IMMUNITY

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

A Paradoxical Role for Neutrophils in the Pathogenesis of West Nile Virus

(2010) Fengwei Bai et al.   JOURNAL OF INFECTIOUS DISEASES

The role of neutrophil apoptosis in juvenile-onset systemic lupus erythematosus

(2009) Angela Midgley et al.   ARTHRITIS AND RHEUMATISM

Pathogenesis of multi-organic failure in autoimmune diseases

(2009) M.C. Amaral et al.   AUTOIMMUNITY REVIEWS

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Granulocyte colony-stimulating factor delays neutrophil apoptosis by inhibition of calpains upstream of caspase-3

(2008) B. J. van Raam et al.   BLOOD

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

(2008) Y. Sawanobori et al.   BLOOD

Neutrophil mobilization and clearance in the bone marrow

(2008) Rebecca C. Furze et al.   IMMUNOLOGY

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens