Neutrophils—Important Communicators in Systemic Lupus Erythematosus and Antiphospholipid Syndrome

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps

(2019) Sebastian Boeltz et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil Extracellular Traps in Arterial and Venous Thrombosis

(2019) Elodie Laridan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Immunological pathogenesis and treatment of systemic lupus erythematosus

(2019) Lu Pan et al.   World Journal of Pediatrics

Anti‐β2GPI/β2GPI induces human neutrophils to generate NETs by relying on ROS

(2019) Yanqiu You et al.   CELL BIOCHEMISTRY AND FUNCTION

Low-density granulocytes activate T cells and demonstrate a non-suppressive role in systemic lupus erythematosus

(2019) Saifur Rahman et al.   ANNALS OF THE RHEUMATIC DISEASES

The Epidemiology of Antiphospholipid Syndrome. A Population‐Based Study

(2019) Ali Duarte‐García et al.   Arthritis & Rheumatology

Increased adhesive potential of antiphospholipid syndrome neutrophils mediated by beta‐2 integrin Mac‐1

(2019) Gautam Sule et al.   Arthritis & Rheumatology

Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA

(2019) Yann Becker et al.   Frontiers in Immunology

MDSCs: friend or foe in systemic lupus erythematosus

(2019) Jianjian Ji et al.   Cellular & Molecular Immunology

NOX2 mediates quiescent handling of dead cell remnants in phagocytes

(2019) Jonas Hahn et al.   Redox Biology

NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages

(2018) Juhi Bagaitkar et al.   BLOOD

Cytokine production by human neutrophils: Revisiting the “dark side of the moon”

(2018) Nicola Tamassia et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

(2018) Markus H. Hoffmann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

The non-haemostatic role of platelets in systemic lupus erythematosus

(2018) Petrus Linge et al.   Nature Reviews Rheumatology

Neutrophil extracellular trap release is associated with antinuclear antibodies in systemic lupus erythematosus and anti-phospholipid syndrome

(2018) Maarten van der Linden et al.   RHEUMATOLOGY

Autoantibodies Recognizing Secondary NEcrotic Cells Promote Neutrophilic Phagocytosis and Identify Patients With Systemic Lupus Erythematosus

(2018) Mona H. C. Biermann et al.   Frontiers in Immunology

Cellular and Molecular Mechanisms of Anti-Phospholipid Syndrome

(2018) Marko Radic et al.   Frontiers in Immunology

The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps

(2018) Angelo A. Manfredi et al.   Frontiers in Immunology

Cleaved N-terminal histone tails distinguish between NADPH oxidase (NOX)-dependent and NOX-independent pathways of neutrophil extracellular trap formation

(2018) Elmar Pieterse et al.   ANNALS OF THE RHEUMATIC DISEASES

Antiphospholipid syndrome – an update

(2018) Birgit Linnemann   Vasa-European Journal of Vascular Medicine

Management of antiphospholipid syndrome

(2018) Imad Uthman et al.   ANNALS OF THE RHEUMATIC DISEASES

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

(2018) Eleni Frangou et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide DNA methylation analysis in primary antiphospholipid syndrome neutrophils

(2018) Emma Weeding et al.   CLINICAL IMMUNOLOGY

Role of Platelets in Leukocyte Recruitment and Resolution of Inflammation

(2018) Jan Rossaint et al.   Frontiers in Immunology

Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression

(2018) Kim Ohl et al.   Frontiers in Immunology

The antiphospholipid syndrome in patients with systemic lupus erythematosus

(2017) Guillermo J. Pons-Estel et al.   JOURNAL OF AUTOIMMUNITY

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases

(2017) Jian Zhao et al.   NATURE GENETICS

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis

(2017) He Meng et al.   Arthritis & Rheumatology

Granulocytes: New Members of the Antigen-Presenting Cell Family

(2017) Ang Lin et al.   Frontiers in Immunology

Endothelial progenitor dysfunction associates with a type I interferon signature in primary antiphospholipid syndrome

(2016) Robert C Grenn et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic aspects of the antiphospholipid syndrome: An update

(2016) Gian Domenico Sebastiani et al.   AUTOIMMUNITY REVIEWS

Matters of life and death. How neutrophils die or survive along NET release and is “NETosis” = necroptosis?

(2016) Jyaysi Desai et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic association study of systemic lupus erythematosus and disease subphenotypes in European populations

(2016) Otsanda Ruiz-Larrañaga et al.   CLINICAL RHEUMATOLOGY

Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry

(2016) Flavia S. Lakschevitz et al.   EXPERIMENTAL CELL RESEARCH

Human neutrophils in the saga of cellular heterogeneity: insights and open questions

(2016) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Neutrophil azurophilic granule exocytosis is primed by TNF-α and partially regulated by NADPH oxidase

(2016) Renee M Potera et al.   Innate Immunity

NADPH oxidase deficiency underlies dysfunction of aged CD8+ Tregs

(2016) Zhenke Wen et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic lupus erythematosus: still a challenge for physicians

(2016) A. A. Bengtsson et al.   JOURNAL OF INTERNAL MEDICINE

Low-density granulocytes: functionally distinct, immature neutrophils in rheumatoid arthritis with altered properties and defective TNF signalling

(2016) Helen L. Wright et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cause and consequences of the activated type I interferon system in SLE

(2016) Maija-Leena Eloranta et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

LAPping up dead cells to prevent lupus nephritis: a novel role for noncanonical autophagy in autoimmunity

(2016) Jeremy S. Leventhal et al.   KIDNEY INTERNATIONAL

Variations in the epidemiology of systemic lupus erythematosus in southern Sweden

(2016) R F Ingvarsson et al.   LUPUS

Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus

(2016) David L Morris et al.   NATURE GENETICS

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Arginase-1–dependent promotion of T H 17 differentiation and disease progression by MDSCs in systemic lupus erythematosus

(2016) Hao Wu et al.   Science Translational Medicine

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

A pathogenic IFNα, BLyS and IL-17 axis in Systemic Lupus Erythematosus patients

(2016) Patricia López et al.   Scientific Reports

Low density granulocytes are increased in the antiphospholipid syndrome and are associated with anti-β2GPI antibodies: Comment on the article by Yalavarthi et al.

(2016) L.L. van den Hoogen et al.   Arthritis & Rheumatology

Elimination of Granulocytic Myeloid-Derived Suppressor Cells in Lupus-Prone Mice Linked to Reactive Oxygen Species-Dependent Extracellular Trap Formation

(2016) Katerina Vlachou et al.   Arthritis & Rheumatology

Myeloid-Derived Suppressor Cells Induce the Expansion of Regulatory B Cells and Ameliorate Autoimmunity in the Sanroque Mouse Model of Systemic Lupus Erythematosus

(2016) Min-Jung Park et al.   Arthritis & Rheumatology

A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis Mimics Based on Differential Requirements for Protein Citrullination

(2016) Maximilian F. Konig et al.   Frontiers in Immunology

Intercellular Interactions as Regulators of NETosis

(2016) Nayef M. Kazzaz et al.   Frontiers in Immunology

Platelets: New Bricks in the Building of Neutrophil Extracellular Traps

(2016) Agostina Carestia et al.   Frontiers in Immunology

Signs of impaired immunoregulation and enhanced effector T-cell responses in the primary antiphospholipid syndrome

(2015) B Jakiela et al.   LUPUS

Increased expression of low density granulocytes in juvenile-onset systemic lupus erythematosus patients correlates with disease activity

(2015) A Midgley et al.   LUPUS

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-derived suppressor cells in major depression patients suppress T-cell responses through the production of reactive oxygen species

(2015) Jianyang Wei et al.   PSYCHIATRY RESEARCH

The risk of pulmonary embolism and deep venous thrombosis in systemic lupus erythematosus: A general population-based study

(2015) J. Antonio Aviña-Zubieta et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome

(2015) Nadine Müller-Calleja et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species

(2015) Xinfang Huang et al.   Cell Reports

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome

(2015) Srilakshmi Yalavarthi et al.   Arthritis & Rheumatology

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Altered Traffic of Cardiolipin during Apoptosis: Exposure on the Cell Surface as a Trigger for “Antiphospholipid Antibodies”

(2015) Valeria Manganelli et al.   Journal of Immunology Research

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2

(2014) Carmelo Carmona-Rivera et al.   ANNALS OF THE RHEUMATIC DISEASES

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

(2014) Tiina Kelkka et al.   ANTIOXIDANTS & REDOX SIGNALING

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Deletion of CD24 Impairs Development of Heat Shock Protein gp96-Driven Autoimmune Disease through Expansion of Myeloid-Derived Suppressor Cells

(2014) J. E. Thaxton et al.   JOURNAL OF IMMUNOLOGY

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Neutrophils scan for activated platelets to initiate inflammation

(2014) Vinatha Sreeramkumar et al.   SCIENCE

Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus

(2014) Anders A Bengtsson et al.   ARTHRITIS RESEARCH & THERAPY

Neutrophil Extracellular Trap-Derived Enzymes Oxidize High-Density Lipoprotein: An Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus

(2014) Carolyne K. Smith et al.   Arthritis & Rheumatology

TLR9 independent interferon α production by neutrophils on NETosis in response to circulating chromatin, a key lupus autoantigen

(2013) Dennis Lindau et al.   ANNALS OF THE RHEUMATIC DISEASES

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Gr-1highCD11b+ Cells Suppress B Cell Differentiation and Lupus-like Disease in Lupus-Prone Male Mice

(2013) Abhishek Trigunaite et al.   ARTHRITIS AND RHEUMATISM

Antiphospholipid antibodies mediate autoimmunity against dying cells

(2013) Laura Andreoli et al.   AUTOIMMUNITY

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Decreased Levels of Circulating CD4+CD25+Foxp3+ Regulatory T Cells in Patients with Primary Antiphospholipid Syndrome

(2013) Ester Rosári Raphaelli Dal Ben et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus

(2013) A. Palanichamy et al.   JOURNAL OF IMMUNOLOGY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

(2013) Carmelo Carmona-Rivera et al.   Seminars in Immunopathology

Endosomal NADPH-oxidase is critical for induction of the tissue factor gene in monocytes and endothelial cells

(2013) Nadine Prinz et al.   THROMBOSIS AND HAEMOSTASIS

Disease Mechanisms in Rheumatology-Tools and Pathways: Plasmacytoid Dendritic Cells and Their Role in Autoimmune Rheumatic Diseases

(2012) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment

(2012) C. Perez-Sanchez et al.   BLOOD

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

Combination of Autoantibodies Against Different Histone Proteins Influences Complement-dependent Phagocytosis of Necrotic Cell Material by Polymorphonuclear Leukocytes in Systemic Lupus Erythematosus

(2012) BIRGITTA GULLSTRAND et al.   JOURNAL OF RHEUMATOLOGY

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures

(2012) Marc Leshner et al.   Frontiers in Immunology

Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I

(2011) Yiannis Ioannou et al.   ARTHRITIS AND RHEUMATISM

Human FoxP3+ regulatory T cells in systemic autoimmune diseases

(2011) Makoto Miyara et al.   AUTOIMMUNITY REVIEWS

Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells

(2011) N. Prinz et al.   BLOOD

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Cardiovascular event in systemic lupus erythematosus in northern Sweden: Incidence and predictors in a 7-year follow-up study

(2011) C Bengtsson et al.   LUPUS

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Disturbances of apoptotic cell clearance in systemic lupus erythematosus

(2011) Wen-Hai Shao et al.   ARTHRITIS RESEARCH & THERAPY

IRF5 is associated with primary antiphospholipid syndrome, but is not a major risk factor

(2010) Micaela Fredi et al.   ARTHRITIS AND RHEUMATISM

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs

(2010) M. F. Denny et al.   JOURNAL OF IMMUNOLOGY

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of regulatory T cells by macrophages is dependent on production of reactive oxygen species

(2010) Marina D. Kraaij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus

(2009) E. Svenungsson et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of the interferon-α production induced by RNA-containing immune complexes in plasmacytoid dendritic cells

(2009) Maija-Leena Eloranta et al.   ARTHRITIS AND RHEUMATISM

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

(2009) Luis E. Muñoz et al.   ARTHRITIS AND RHEUMATISM

Genetic risk factors of thrombosis in the antiphospholipid syndrome

(2009) Jesús Castro-Marrero et al.   BRITISH JOURNAL OF HAEMATOLOGY

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases

(2009) Jamel El-Benna et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE)

(2008) C. Janko et al.   AUTOIMMUNITY REVIEWS

Antiphospholipid syndrome during pegylated interferon alpha-2a therapy for chronic hepatitis C

(2008) D.C. Balderramo et al.   DIGESTIVE AND LIVER DISEASE

Regulation of B-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils

(2007) Patrizia Scapini et al.   IMMUNOLOGY LETTERS