Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Severe COVID‐19 infection and thrombotic microangiopathy: success does not come easily

(2020) Eleni Gavriilaki et al.   BRITISH JOURNAL OF HAEMATOLOGY

Will Complement Inhibition Be the New Target in Treating COVID-19–Related Systemic Thrombosis?

(2020) Courtney M. Campbell et al.   CIRCULATION

Complement activation in patients with COVID-19: A novel therapeutic target

(2020) Massimo Cugno et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

A serological assay to detect SARS-CoV-2 seroconversion in humans

(2020) Fatima Amanat et al.   NATURE MEDICINE

Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19

(2020) Yan Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

Immunotherapies for COVID-19: lessons learned from sepsis

(2020) Kenneth E Remy et al.   Lancet Respiratory Medicine

The first case of COVID-19 treated with the complement C3 inhibitor AMY-101

(2020) Sara Mastaglio et al.   CLINICAL IMMUNOLOGY

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

(2020) Julien Carvelli et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Severe COVID-19 infection associated with endothelial activation

(2020) Robert Escher et al.   THROMBOSIS RESEARCH

Anti-complement C5 therapy with eculizumab in three cases of critical COVID-19

(2020) Jeffrey Laurence et al.   CLINICAL IMMUNOLOGY

Innate immune responses to trauma

(2018) Markus Huber-Lang et al.   NATURE IMMUNOLOGY

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4-transgenic mice infected with MERS-CoV

(2018) Yuting Jiang et al.   Emerging Microbes & Infections

A high-throughput pipeline for validation of antibodies

(2018) Krzysztof Sikorski et al.   NATURE METHODS

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

(2018) Lisa E. Gralinski et al.   mBio

Complement in clinical medicine: Clinical trials, case reports and therapy monitoring

(2017) Daniel Ricklin et al.   MOLECULAR IMMUNOLOGY

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

(2016) Kristina N. Ekdahl et al.   IMMUNOLOGICAL REVIEWS

Assessment of Clinical Criteria for Sepsis

(2016) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5 emerge together with CD14 as promising targets

(2016) Andreas Barratt-Due et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome

(2016) Andreas Barratt-Due et al.   RHEUMATOLOGY

Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo

(2015) E. B. Volokhina et al.   BLOOD

The role of C5a in acute lung injury induced by highly pathogenic viral infections

(2015) Renxi Wang et al.   Emerging Microbes & Infections

An international serum standard for application in assays to detect human complement activation products

(2013) Grethe Bergseth et al.   MOLECULAR IMMUNOLOGY

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

International Study of the Prevalence and Outcomes of Infection in Intensive Care Units

(2009) Jean-Louis Vincent   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibody Array Analysis with Label-based Detection and Resolution of Protein Size

(2008) Weiwei Wu et al.   MOLECULAR & CELLULAR PROTEOMICS