Missing in action-The meaning of cell death in tissue damage and inflammation

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review

(2017) Tamara Hoppenbrouwers et al.   PLoS One

Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity

(2017) J. Stephen et al.   npj Vaccines

A blast without power – cell death induced by the tuberculosis-necrotizing toxin fails to elicit adequate immune responses

(2016) C Maueröder et al.   CELL DEATH AND DIFFERENTIATION

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease and cancer

(2016) R B Birge et al.   CELL DEATH AND DIFFERENTIATION

Sialylation of anti-histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells

(2016) I. Magorivska et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tumor-Produced Interleukin-8 Attracts Human Myeloid-Derived Suppressor Cells and Elicits Extrusion of Neutrophil Extracellular Traps (NETs)

(2016) C. Alfaro et al.   CLINICAL CANCER RESEARCH

New insights into the pathways initiating and driving pancreatitis

(2016) Anna S. Gukovskaya et al.   CURRENT OPINION IN GASTROENTEROLOGY

Neutrophils in cancer

(2016) Louise W. Treffers et al.   IMMUNOLOGICAL REVIEWS

Neutrophil swarming: an essential process of the neutrophil tissue response

(2016) Korbinian Kienle et al.   IMMUNOLOGICAL REVIEWS

Papillon-Lefèvre syndrome: report of six patients and identification of a novel mutation

(2016) Burak Tekin et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Natural History After Acute Necrotizing Pancreatitis: a Large US Tertiary Care Experience

(2016) Chandraprakash Umapathy et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Characterization of neutrophil function in Papillon-Lefèvre syndrome

(2016) Helen Roberts et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Contact system revisited: an interface between inflammation, coagulation, and innate immunity

(2016) A. T. Long et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease

(2016) René Pfeifle et al.   NATURE IMMUNOLOGY

Reply to "Neutrophils are not required for resolution of acute gouty arthritis in mice"

(2016) Christiane Reinwald et al.   NATURE MEDICINE

Acute Pancreatitis

(2016) Chris E. Forsmark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation

(2016) Luis E. Muñoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

(2016) Moritz Leppkes et al.   Nature Communications

A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM

(2016) Haoyang Zhuang et al.   Arthritis & Rheumatology

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs

(2016) Christian Maueröder et al.   Frontiers in Immunology

NETosis as Source of Autoantigens in Rheumatoid Arthritis

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation

(2016) Mona H. C. Biermann et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Form a Barrier between Necrotic and Viable Areas in Acute Abdominal Inflammation

(2016) Rostyslav Bilyy et al.   Frontiers in Immunology

NETosis – Does It Really Represent Nature’s “Suicide Bomber”?

(2016) Shida Yousefi et al.   Frontiers in Immunology

The role of neutrophils in the pathogenesis of systemic lupus erythematosus

(2015) Carolyne K. Smith et al.   CURRENT OPINION IN RHEUMATOLOGY

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis

(2015) Mohammed Merza et al.   GASTROENTEROLOGY

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

(2015) Rikard Holmdahl et al.   IMMUNOLOGICAL REVIEWS

Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis

(2015) A. Warnatsch et al.   SCIENCE

Potential role of Th17 cells in the pathogenesis of type 2 autoimmune pancreatitis

(2015) M. Loos et al.   VIRCHOWS ARCHIV

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

(2015) Elzbieta Kolaczkowska et al.   Nature Communications

Phenotypic Diversity and Plasticity in Circulating Neutrophil Subpopulations in Cancer

(2015) Jitka Y. Sagiv et al.   Cell Reports

Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis

(2015) Sonja Herman et al.   Arthritis & Rheumatology

The complement system in systemic lupus erythematosus: an update

(2014) Jonatan Leffler et al.   ANNALS OF THE RHEUMATIC DISEASES

Reactive Oxygen Species Deficiency Induces Autoimmunity with Type 1 Interferon Signature

(2014) Tiina Kelkka et al.   ANTIOXIDANTS & REDOX SIGNALING

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Mechanism of Action of Colchicine in the Treatment of Gout

(2014) Nicola Dalbeth et al.   CLINICAL THERAPEUTICS

The role of dead cell clearance in the etiology and pathogenesis of systemic lupus erythematosus: dendritic cells as potential targets

(2014) Mona HC Biermann et al.   Expert Review of Clinical Immunology

The Nuclear Receptor Nr4a1 Mediates Anti-Inflammatory Effects of Apoptotic Cells

(2014) N. Ipseiz et al.   JOURNAL OF IMMUNOLOGY

Altered glycosylation of complexed native IgG molecules is associated with disease activity of systemic lupus erythematosus

(2014) C Sjöwall et al.   LUPUS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

No Evidence of Pathogenic Involvement of Cathelicidins in Patient Cohorts and Mouse Models of Lupus and Arthritis

(2014) D. Kienhöfer et al.   PLoS One

The Progression of Cell Death Affects the Rejection of Allogeneic Tumors in Immune-Competent Mice – Implications for Cancer Therapy

(2014) Ricardo A. Chaurio et al.   Frontiers in Immunology

Breaking Immunological Tolerance in Systemic Lupus Erythematosus

(2014) Elmar Pieterse et al.   Frontiers in Immunology

Thrombosis: tangled up in NETs

(2013) K. Martinod et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids

(2013) K Lauber et al.   CELL DEATH AND DIFFERENTIATION

Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration

(2013) Benjamin Weichand et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The variant of CD11b, rs1143679 within ITGAM, is associated with systemic lupus erythematosus and clinical manifestations in Brazilian patients

(2013) Juliana Escher Toller-Kawahisa et al.   HUMAN IMMUNOLOGY

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model

(2013) Lianhu Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Opie’s hypothesis revisited: Acute pancreatitis due to bile reflux into the pancreas

(2013) J. Matthias Löhr et al.   PANCREATOLOGY

Cooperative binding of Annexin A5 to phosphatidylserine on apoptotic cell membranes

(2013) Christina Janko et al.   PHYSICAL BIOLOGY

Surface code—biophysical signals for apoptotic cell clearance

(2013) Mona Biermann et al.   PHYSICAL BIOLOGY

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-density granulocytes: a distinct class of neutrophils in systemic autoimmunity

(2013) Carmelo Carmona-Rivera et al.   Seminars in Immunopathology

Molecular circuits in thrombosis and inflammation

(2013) Charles Esmon   THROMBOSIS AND HAEMOSTASIS

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Diminished Expression of Complement Regulatory Proteins on Peripheral Blood Cells from Systemic Lupus Erythematosus Patients

(2012) Ana Paula Alegretti et al.   Clinical & Developmental Immunology

Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus

(2012) Peter A Banks et al.   GUT

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

How nascent phagosomes mature to become phagolysosomes

(2012) Gregory D. Fairn et al.   TRENDS IN IMMUNOLOGY

Monosodium urate crystals induce extracellular DNA traps in neutrophils, eosinophils, and basophils but not in mononuclear cells

(2012) Christine Schorn et al.   Frontiers in Immunology

Acquired Loss of Renal Nuclease Activity Is Restricted to DNaseI and Is an Organ-Selective Feature in Murine Lupus Nephritis

(2011) Natalya Seredkina et al.   AMERICAN JOURNAL OF PATHOLOGY

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophages Discriminate Glycosylation Patterns of Apoptotic Cell-derived Microparticles

(2011) Rostyslav O. Bilyy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps promote deep vein thrombosis in mice

(2011) A. BRILL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Histopathologic and Clinical Subtypes of Autoimmune Pancreatitis: The Honolulu Consensus Document

(2011) Suresh T. Chari et al.   PANCREATOLOGY

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

CRP/anti-CRP Antibodies Assembly on the Surfaces of Cell Remnants Switches Their Phagocytic Clearance Toward Inflammation

(2011) Christina Janko et al.   Frontiers in Immunology

Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells

(2010) Christoph Peter et al.   APOPTOSIS

IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE

(2010) Luis E. Munoz et al.   AUTOIMMUNITY

The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations

(2010) Christine Schorn et al.   AUTOIMMUNITY

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes

(2010) H. M. Meesmann et al.   JOURNAL OF CELL SCIENCE

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

A Step-up Approach or Open Necrosectomy for Necrotizing Pancreatitis

(2010) Hjalmar C. van Santvoort et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

(2009) Luis E. Muñoz et al.   ARTHRITIS AND RHEUMATISM

MoMa from patients with systemic lupus erythematosus show altered adhesive activity

(2009) Luis E. Muñoz et al.   AUTOIMMUNITY

Treatment with DNAse I fosters binding to nec PBMC of CRP

(2009) Christina Janko et al.   AUTOIMMUNITY

AnnexinA5 renders dead tumor cells immunogenic—implications for multimodal cancer therapies

(2009) Benjamin Frey et al.   Journal of Immunotoxicology

Phospholipids: Key Players in Apoptosis and Immune Regulation

(2009) Ricardo Chaurio et al.   MOLECULES

Inflammatory clearance of apoptotic remnants in systemic lupus erythematosus (SLE)

(2008) C. Janko et al.   AUTOIMMUNITY REVIEWS

Clearance deficiency—A potential link between infections and autoimmunity

(2008) C. Schulze et al.   AUTOIMMUNITY REVIEWS

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Chronic granulomatous disease as a risk factor for autoimmune disease

(2008) Suk See De Ravin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype

(2008) Benjamin Frey et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity

(2008) V. Shpacovitch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE