Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-κB activated pyroptosis pathways

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(2021) Jiang‐Hua Liu et al.   Advanced Science

Comprehensive Analysis of LncRNA-mRNA Expression Profiles and the ceRNA Network Associated with Pyroptosis in LPS-Induced Acute Lung Injury

(2021) Deqiang Luo et al.   Journal of Inflammation Research

Immunomodulatory Role of Urolithin A on Metabolic Diseases

(2021) Ashley Mulcahy Toney et al.   Biomedicines

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

(2021) Michelle M. McDonald et al.   CELL

Exosomes from adipose derived mesenchymal stem cells alleviate diabetic osteoporosis in rats through suppressing NLRP3 inflammasome activation in osteoclasts

(2021) Lei Zhang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Estrogenic Effects of Extracts and Isolated Compounds from Belowground and Aerial Parts of Spartina anglica

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Natural products as geroprotectors: An autophagy perspective

(2021) Stephen D. Raj et al.   MEDICINAL RESEARCH REVIEWS

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

(2021) Peiling Luan et al.   Science Translational Medicine

Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination

(2021) Huo-Liang Zheng et al.   Cell Death & Disease

SLPI is a critical mediator that controls PTH-induced bone formation

(2021) Akito Morimoto et al.   Nature Communications

The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs

(2021) Khalid N. M. Abdelazeem et al.   Scientific Reports

Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment?

(2021) Claire Dumortier et al.   Frontiers in Cell and Developmental Biology

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

(2021) Ming-Li Zou et al.   Frontiers in Molecular Biosciences

Late‐in‐life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts

(2021) Jae Min Cho et al.   AGING CELL

Postmenopausal Osteoporosis

(2021) Rod Marianne Arceo-Mendoza et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Denosumab Discontinuation in Patients Treated for Low Bone Density and Osteoporosis

(2021) Meltem Zeytinoglu et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Cardamonin Inhibited IL-1β Induced Injury by Inhibition of NLRP3 Inflammasome via Activating Nrf2/NQO-1 Signaling Pathway in Chondrocyte

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Osteoporosis, bisphosphonate use, and risk of moderate or worse hearing loss in women

(2021) Sharon G. Curhan et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells

(2021) Iqra Nazish et al.   NEUROCHEMISTRY INTERNATIONAL

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

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Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration

(2021) Assraa Hassan Jassim et al.   Frontiers in Pharmacology

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes

(2021) Weimin Fan et al.   Journal of Inflammation Research

Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis

(2021) Pan Shen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mitophagy in depression: Pathophysiology and treatment targets

(2021) Ashutosh Tripathi et al.   MITOCHONDRION

Interaction between bone and immune cells: Implications for postmenopausal osteoporosis

(2021) Verena Fischer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Tuna Bone Powder Alleviates Glucocorticoid‐Induced Osteoporosis via Coregulation of the NF‐κB and Wnt/β‐Catenin Signaling Pathways and Modulation of Gut Microbiota Composition and Metabolism

(2020) Jingjing Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Evaluation of genetic variants in IL‐1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population

(2020) Zhiyi He et al.   JOURNAL OF GENE MEDICINE

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway

(2020) Emad H. M. Hassanein et al.   Oxidative Medicine and Cellular Longevity

Diaporisoindole E inhibits RANKL-induced osteoclastogenesis via suppression of PI3K/AKT and MAPK signal pathways

(2020) Pei Hua et al.   PHYTOMEDICINE

Muscone Ameliorates Ovariectomy-Induced Bone Loss and Receptor Activator of Nuclear Factor-κb Ligand-Induced Osteoclastogenesis by Suppressing TNF Receptor–Associated Factor 6-Mediated Signaling Pathways

(2020) Xiao Zhai et al.   Frontiers in Pharmacology

Near-Infrared Light Triggered Phototherapy and Immunotherapy for Elimination of Methicillin-Resistant Staphylococcus aureus Biofilm Infection on Bone Implant

(2020) Yuan Li et al.   ACS Nano

Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis

(2020) Houchen Lyu et al.   ANNALS OF INTERNAL MEDICINE

Targeting NLRP3 Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss

(2020) Y. Zang et al.   JOURNAL OF DENTAL RESEARCH

Serial Bone Density Measurement and Incident Fracture Risk Discrimination in Postmenopausal Women

(2020) Carolyn J. Crandall et al.   JAMA Internal Medicine

PKC-δ deficiency in B cells displays osteopenia accompanied with upregulation of RANKL expression and osteoclast–osteoblast uncoupling

(2020) Shangfu Li et al.   Cell Death & Disease

NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation

(2020) Yuyi Chen et al.   CELL PROLIFERATION

Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice

(2020) Zhiyuan Guan et al.   CLINICAL SCIENCE

A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity

(2020) Yueqi Chen et al.   Clinical and Translational Medicine

Natural compounds modulate the autophagy with potential implication of stroke

(2020) Anil Ahsan et al.   Acta Pharmaceutica Sinica B

Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis

(2019) Ashley Mulcahy Toney et al.   Obesity

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

LY411575, a potent γ‐secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS‐induced calvarial osteolysis in vivo

(2019) Xinwei Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis

(2019) Xiaobo Zhu et al.   Annals of Translational Medicine

Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis

(2019) Yanan An et al.   FASEB JOURNAL

Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss

(2019) Yu-Ru V. Shih et al.   Science Advances

A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL induced NFATc-1/c-Fos induction

(2018) Ke Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E2 Levels

(2018) Youn-Hwan Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

(2018) Sarah Weske et al.   NATURE MEDICINE

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Postmenopausal health interventions: Time to move on from the Women’s Health Initiative?

(2018) Jay Jay Thaung Zaw et al.   AGEING RESEARCH REVIEWS

Highly Dispersed Fullerenols Hamper Osteoclast Ruffled Border Formation by Perturbing Ca2+ Bundles

(2018) Weihong Gu et al.   Small

Protocatechuic acid inhibits osteoclast differentiation and stimulates apoptosis in mature osteoclasts

(2016) Yi-Xin Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

(2016) Inhae Kang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Postmenopausal osteoporosis

(2016) Richard Eastell et al.   Nature Reviews Disease Primers

An Association Between Abnormal Bone Turnover, Systemic Inflammation and Osteoporosis in Patients With Chronic Pancreatitis: A Case-Matched Study

(2015) Sinead N Duggan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Monosodium Urate in the Presence of RANKL Promotes Osteoclast Formation through Activation of c-Jun N-Terminal Kinase

(2015) Jung-Yoon Choe et al.   MEDIATORS OF INFLAMMATION

Improving RNA-Seq expression estimates by correcting for fragment bias

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