Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis

Plasma urolithin metabolites correlate with improvements in endothelial function after red raspberry consumption: A double-blind randomized controlled trial

(2018) Geoffrey Istas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

(2018) Yaw Duah Boakye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The gut microbiota metabolism of pomegranate or walnut ellagitannins yields two urolithin-metabotypes that correlate with cardiometabolic risk biomarkers: Comparison between normoweight, overweight-obesity and metabolic syndrome

(2018) María V. Selma et al.   CLINICAL NUTRITION

Urolithin A attenuates pro-inflammatory mediator production by suppressing PI3-K/Akt/NF-κB and JNK/AP-1 signaling pathways in lipopolysaccharide-stimulated RAW264 macrophages: Possible involvement of NADPH oxidase-derived reactive oxygen species

(2018) Wataru Komatsu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolic fate of strawberry polyphenols after chronic intake in healthy older adults

(2018) Amandeep K. Sandhu et al.   Food & Function

Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1

(2018) Liang Zhao et al.   Nutrition & Diabetes

Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid

(2017) Jacqueline Heilman et al.   FOOD AND CHEMICAL TOXICOLOGY

Chromatographic and spectroscopic characterization of urolithins for their determination in biological samples after the intake of foods containing ellagitannins and ellagic acid

(2016) Rocío García-Villalba et al.   JOURNAL OF CHROMATOGRAPHY A

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

(2016) Inhae Kang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects on Nitric Oxide Production of Urolithins, Gut-Derived Ellagitannin Metabolites, in Human Aortic Endothelial Cells

(2016) Valentina Spigoni et al.   MOLECULES

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Improvements in Metabolic Health with Consumption of Ellagic Acid and Subsequent Conversion into Urolithins: Evidence and Mechanisms

(2016) Inhae Kang et al.   Advances in Nutrition

Dietary Polyphenols Promote Growth of the Gut BacteriumAkkermansia muciniphilaand Attenuate High-Fat Diet–Induced Metabolic Syndrome

(2015) Diana E. Roopchand et al.   DIABETES

Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages

(2015) Jakub P. Piwowarski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The gut microbiota in human energy homeostasis and obesity

(2015) Michael Rosenbaum et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions

(2014) Giorgio Ghigliotti et al.   INFLAMMATION

Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment

(2014) L Zhao et al.   INTERNATIONAL JOURNAL OF OBESITY

Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification

(2014) Inhae Kang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

(2014) Jakub Piwowarski et al.   PLANTA MEDICA

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

(2013) Antonio González-Sarrías et al.   EUROPEAN JOURNAL OF NUTRITION

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections

(2012) Miguel Galarraga et al.   JOURNAL OF LIPID RESEARCH

Ellagitannin metabolites, urolithin A glucuronide and its aglycone urolithin A, ameliorate TNF-α-induced inflammation and associated molecular markers in human aortic endothelial cells

(2012) Juan A. Giménez-Bastida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts

(2010) Antonio González-Sarrías et al.   BRITISH JOURNAL OF NUTRITION

DissimilarIn VitroandIn VivoEffects of Ellagic Acid and Its Microbiota-Derived Metabolites, Urolithins, on the Cytochrome P450 1A1

(2009) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dose translation from animal to human studies revisited

(2007) Shannon Reagan-Shaw et al.   FASEB JOURNAL