Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

(2019) Davide D’Amico et al.   MOLECULAR CELL

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

(2019) Nicola Vannini et al.   Cell Stem Cell

Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H 2 O 2 emission during impaired oxidative phosphorylation

(2019) Meghan C. Hughes et al.   Journal of Cachexia Sarcopenia and Muscle

Mitochondrial content is preserved throughout disease progression in the mdx mouse model of Duchenne muscular dystrophy, regardless of taurine supplementation

(2018) Robert G. Barker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Combined Therapies for Duchenne Muscular Dystrophy to Optimize Treatment Efficacy

(2018) Gonzalo Cordova et al.   Frontiers in Genetics

CRISPR Correction of Duchenne Muscular Dystrophy

(2018) Yi-Li Min et al.   Annual Review of Medicine

Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice

(2018) Rio Sebori et al.   Oxidative Medicine and Cellular Longevity

Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid

(2017) Jacqueline Heilman et al.   FOOD AND CHEMICAL TOXICOLOGY

Exercise in claudicants increase or decrease walking ability and the response relates to mitochondrial function

(2017) Michel van Schaardenburgh et al.   Journal of Translational Medicine

Progress toward Gene Therapy for Duchenne Muscular Dystrophy

(2017) Joel R. Chamberlain et al.   MOLECULAR THERAPY

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review

(2017) S. Ryder et al.   Orphanet Journal of Rare Diseases

Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues

(2017) Annemieke Aartsma-Rus et al.   Nucleic Acid Therapeutics

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

(2016) Alejandro Vazquez-Martin et al.   Aging-US

Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy

(2016) Maria C Vila et al.   CELL DEATH AND DIFFERENTIATION

Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles

(2016) E Fiacco et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

(2016) Mandy Koopman et al.   Nature Protocols

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

(2016) D. Ryu et al.   Science Translational Medicine

Satellite Cells in Muscular Dystrophy – Lost in Polarity

(2016) Natasha C. Chang et al.   TRENDS IN MOLECULAR MEDICINE

New method to assess mitophagy flux by flow cytometry

(2015) Marta Mauro-Lizcano et al.   Autophagy

Ultra-structural time-course study in theC. elegansmodel for Duchenne muscular dystrophy highlights a crucial role for sarcomere-anchoring structures and sarcolemma integrity in the earliest steps of the muscle degeneration process

(2015) Nicolas Brouilly et al.   HUMAN MOLECULAR GENETICS

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting

(2015) Ling Liu et al.   Nature Protocols

Muscular dystrophy in the mdx mouse is a severe myopathy compounded by hypotrophy, hypertrophy and hyperplasia

(2015) William Duddy et al.   Skeletal Muscle

PGC-1α modulates denervation-induced mitophagy in skeletal muscle

(2015) Anna Vainshtein et al.   Skeletal Muscle

Metabolic Dysfunction and Altered Mitochondrial Dynamics in the Utrophin-Dystrophin Deficient Mouse Model of Duchenne Muscular Dystrophy

(2015) Meghna Pant et al.   PLoS One

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Duchenne and Becker Muscular Dystrophies

(2014) Kevin M. Flanigan   NEUROLOGIC CLINICS

A systematic review and meta-analysis on the epidemiology of Duchenne and Becker muscular dystrophy

(2014) Jean K. Mah et al.   NEUROMUSCULAR DISORDERS

Defects in Mitochondrial ATP Synthesis in Dystrophin-Deficient Mdx Skeletal Muscles May Be Caused by Complex I Insufficiency

(2014) Emma Rybalka et al.   PLoS One

Mitophagy Is Required for Acute Cardioprotection by Simvastatin

(2013) Allen M. Andres et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy in hematopoietic stem cells

(2013) Aashish Joshi et al.   Autophagy

Isolation and Culture of Individual Myofibers and their Satellite Cells from Adult Skeletal Muscle

(2013) Alessandra Pasut et al.   Jove-Journal of Visualized Experiments

Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition

(2012) J. M. Percival et al.   HUMAN MOLECULAR GENETICS

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Autophagy induction rescues muscular dystrophy

(2011) Paolo Grumati et al.   Autophagy

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice

(2010) Alessandra Sacco et al.   CELL

Mechanisms of muscle weakness in muscular dystrophy: Figure 1.

(2010) Jeffery A. Goldstein et al.   JOURNAL OF GENERAL PHYSIOLOGY

Role of TRPC1 channel in skeletal muscle function

(2009) Nadège Zanou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY