Mitophagy in depression: Pathophysiology and treatment targets

Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives

(2021) Evgeny A. Ermakov et al.   Oxidative Medicine and Cellular Longevity

BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects

(2021) Gee Euhn Choi et al.   Nature Communications

The Efficacy, Safety, and Tolerability of Probiotics on Depression: Clinical Results From an Open-Label Pilot Study

(2021) Caroline J. K. Wallace et al.   Frontiers in Psychiatry

Nutrition as Metabolic Treatment for Anxiety

(2021) Nicholas G. Norwitz et al.   Frontiers in Psychiatry

Type 1 interferon mediates chronic stress-induced neuroinflammation and behavioral deficits via complement component 3-dependent pathway

(2021) Ashutosh Tripathi et al.   MOLECULAR PSYCHIATRY

Simulated vehicle exhaust exposure induces sex-dependent behavioral deficits in rats

(2021) Camila Kochi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Mitochondrial Ca2+ oscillation induces mitophagy initiation through the PINK1-Parkin pathway

(2021) Zhengying Yu et al.   Cell Death & Disease

Non-motor Symptoms in Parkinson’s Disease Patients with Parkin Mutations: More Depression and Less Executive Dysfunction

(2020) Jie Song et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia

(2020) Shutian Zhang et al.   Journal of Neuroinflammation

Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination

(2020) Su Jin Ham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

(2020) Natalia Moskal et al.   Nature Communications

The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes

(2020) Lin Cui et al.   Frontiers in Cell and Developmental Biology

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

Metformin Improves the Depression Symptoms of Women with Polycystic Ovary Syndrome in a Lifestyle Modification Program

(2020) Fatimah AlHussain et al.   Patient Preference and Adherence

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway

(2020) Jia Luo et al.   International Journal of Environmental Research and Public Health

Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice

(2020) Xiaoxian Xie et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Role of Cathepsins in Memory Functions and the Pathophysiology of Psychiatric Disorders

(2020) Christine Niemeyer et al.   Frontiers in Psychiatry

Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction

(2020) Chen Li et al.   Frontiers in Cell and Developmental Biology

Alterations in mitochondrial dynamic-related genes in the peripheral blood of Alzheimer’s disease patients

(2020) Nattaporn Pakpian et al.   Current Alzheimer Research

The deleterious effect of stress‐induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway

(2020) Mona A. Kortam et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy

(2020) Qi Zhang et al.   MOLECULES

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

The effect of fasting or calorie restriction on mitophagy induction: a literature review

(2020) Sanaz Mehrabani et al.   Journal of Cachexia Sarcopenia and Muscle

Metformin: A Prospective Alternative for the Treatment of Chronic Pain

(2020) Guadalupe Del Carmen Baeza-Flores et al.   Frontiers in Pharmacology

Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies

(2020) Rosalinda C. Roberts   MITOCHONDRION

Regulatory Roles of Sortilin and SorLA in Immune-Related Processes

(2019) Hugo Talbot et al.   Frontiers in Pharmacology

The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin and Its Role in the Membrane Expression of TREK-1

(2019) Jean Mazella et al.   Frontiers in Pharmacology

Treadmill Exercise Ameliorates Depression-Like Behavior in the Rats With Prenatal Dexamethasone Exposure: The Role of Hippocampal Mitochondria

(2019) Tianwen Wu et al.   Frontiers in Neuroscience

Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

(2019) Hisaomi Suzuki et al.   Frontiers in Cellular Neuroscience

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

(2019) Annadurai Thangaraj et al.   Autophagy

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice

(2019) Sandeep K. Agnihotri et al.   BEHAVIOURAL BRAIN RESEARCH

Exercise-Induced Mitophagy in Skeletal Muscle and Heart

(2019) Yuntian Guan et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Mitochondrial DNA copy number, damage, repair and degradation in depressive disorder

(2019) Piotr Czarny et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Is There a Role of Autophagy in Depression and Antidepressant Action?

(2019) Nils C. Gassen et al.   Frontiers in Psychiatry

Mitochondrial DNA Copy Number Raises the Potential of Left Frontopolar Hemodynamic Response as a Diagnostic Marker for Distinguishing Bipolar Disorder From Major Depressive Disorder

(2019) Noa Tsujii et al.   Frontiers in Psychiatry

Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action

(2019) Shipra Bhansali et al.   Annals of the New York Academy of Sciences

Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells

(2019) Ning Mu et al.   APOPTOSIS

Outstanding Questions in Mitophagy: What We Do and Do Not Know

(2019) Lambert Montava-Garriga et al.   JOURNAL OF MOLECULAR BIOLOGY

Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids

(2019) Juliane Zemdegs et al.   JOURNAL OF NEUROSCIENCE

The antidepressant- and anxiolytic-like effects of resveratrol: Involvement of phosphodiesterase-4D inhibition

(2019) Xia Zhu et al.   NEUROPHARMACOLOGY

Prebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trials

(2019) Richard T. Liu et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

(2019) Xiaodong Shu et al.   Cell Death & Disease

Cognitive and psychiatric symptoms in genetically determined Parkinson’s disease: a systematic review

(2019) R. Piredda et al.   EUROPEAN JOURNAL OF NEUROLOGY

Depressive Symptoms Predict Change in Telomere Length and Mitochondrial DNA Copy Number Across Adolescence

(2019) Kathryn L. Humphreys et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

Extracellular mitochondrial DNA promote NLRP3 inflammasome activation and induce acute lung injury through TLR9 and NF-κB

(2019) Guannan Wu et al.   Journal of Thoracic Disease

Mitochondrial calcium signaling as a therapeutic target for Alzheimer’s disease

(2019) Aston Jiaxi Wu et al.   Current Alzheimer Research

Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1‐dependent mitophagy in a Salmonella infantis model of piglet diarrhea

(2019) Bing Xia et al.   FASEB JOURNAL

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice

(2019) Xiaoxian Xie et al.   JOURNAL OF AFFECTIVE DISORDERS

Metformin ameliorates stress-induced depression-like behaviors via enhancing the expression of BDNF by activating AMPK/CREB-mediated histone acetylation

(2019) Wenting Fang et al.   JOURNAL OF AFFECTIVE DISORDERS

Exercise and mitochondrial health

(2019) Jonathan M. Memme et al.   JOURNAL OF PHYSIOLOGY-LONDON

Investigation of mitochondrial DNA copy number in patients with major depressive disorder

(2019) Jae Kyung Chung et al.   PSYCHIATRY RESEARCH

Probiotics exert reciprocal effects on autophagy and interleukin-1β expression in Salmonella-infected intestinal epithelial cells via autophagy-related 16L1 protein

(2019) W.-T. Lai et al.   Beneficial Microbes

Involvement of oxidative stress and mitochondrial mechanisms in air pollution-related neurobiological impairments

(2019) Ankita Salvi et al.   Neurobiology of Stress

HIV-1 TAT-mediated microglial activation: Role of mitochondrial dysfunction and defective mitophagy

(2018) Annadurai Thangaraj et al.   Autophagy

Differential mitochondrial DNA copy number in three mood states of bipolar disorder

(2018) Dong Wang et al.   BMC Psychiatry

Complement component 3a receptor deficiency attenuates chronic stress-induced monocyte infiltration and depressive-like behavior

(2018) Amanda Crider et al.   BRAIN BEHAVIOR AND IMMUNITY

Deletion of asparagine endopeptidase reduces anxiety- and depressive-like behaviors and improves abilities of spatial cognition in mice

(2018) Jing Gao et al.   BRAIN RESEARCH BULLETIN

Changes in Activity of Cysteine Cathepsins B and L in Brain Structures of Mice with Aggressive and Depressive-Like Behavior Formed under Conditions of Social Stress

(2018) S. Ya. Zhanaeva et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

(2018) Aida Rodríguez‐Nuevo et al.   EMBO JOURNAL

Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy

(2018) Claire L. McGrory et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats

(2018) Martin Hadamitzky et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

High levels of mitochondrial DNA are associated with adolescent brain structural hypoconnectivity and increased anxiety but not depression

(2018) Olga Tymofiyeva et al.   JOURNAL OF AFFECTIVE DISORDERS

Basal mitophagy is widespread inDrosophilabut minimally affected by loss of Pink1 or parkin

(2018) Juliette J. Lee et al.   JOURNAL OF CELL BIOLOGY

The impact of stress on sleep: Pathogenic sleep reactivity as a vulnerability to insomnia and circadian disorders

(2018) David A. Kalmbach et al.   JOURNAL OF SLEEP RESEARCH

Mitophagy and the release of inflammatory cytokines

(2018) James Harris et al.   MITOCHONDRION

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

(2018) Plamena R. Angelova et al.   MOLECULAR NEUROBIOLOGY

The multifaceted contributions of mitochondria to cellular metabolism

(2018) Jessica B. Spinelli et al.   NATURE CELL BIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse

(2018) Jie Tang et al.   NEUROCHEMICAL RESEARCH

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

(2018) Daniel Lindqvist et al.   NEUROPSYCHOPHARMACOLOGY

Effect of resveratrol on cognitive and memory performance and mood: A meta-analysis of 225 patients

(2018) Mohammad Hosein Farzaei et al.   PHARMACOLOGICAL RESEARCH

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

(2018) Josh Allen et al.   Frontiers in Neuroscience

The Role of Mitophagy in Innate Immunity

(2018) Ilias Gkikas et al.   Frontiers in Immunology

Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress

(2018) Amal Ahmed Abd El-Fattah et al.   BRAIN RESEARCH

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Peroxisome proliferator-activated receptor gamma co-activator-1 alpha in depression and the response to electroconvulsive therapy

(2018) Karen M. Ryan et al.   PSYCHOLOGICAL MEDICINE

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation

(2018) Giselli Scaini et al.   NEUROPSYCHOPHARMACOLOGY

Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice

(2018) Rio Sebori et al.   Oxidative Medicine and Cellular Longevity

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

(2018) Chenzhong Wang et al.   BioScience Trends

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury

(2018) Qiang Li et al.   Frontiers in Neuroscience

Inhibition of Autophagy in Microglia Alters Depressive-Like Behavior via BDNF Pathway in Postpartum Depression

(2018) Xiaoning Tan et al.   Frontiers in Psychiatry

Depression caused by long-term stress regulates premature aging and is possibly associated with disruption of circadian rhythms in mice

(2018) Xiaoxian Xie et al.   PHYSIOLOGY & BEHAVIOR

Rho-kinase inhibition has antidepressant-like efficacy and expedites dendritic spine pruning in adolescent mice

(2018) Lauren P. Shapiro et al.   NEUROBIOLOGY OF DISEASE

Association of mitochondrial DNA in peripheral blood with depression, anxiety and stress- and adjustment disorders in primary health care patients

(2017) Xiao Wang et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute mental stress induces mitochondrial bioenergetic crisis and hyper-fission along with aberrant mitophagy in the gut mucosa in rodent model of stress-related mucosal disease

(2017) Rudranil De et al.   FREE RADICAL BIOLOGY AND MEDICINE

Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome

(2017) Maria Ines Pinto-Sanchez et al.   GASTROENTEROLOGY

Modulating Oxidative Stress Relieves Stress-Induced Behavioral and Cognitive Impairments in Rats

(2017) Naimesh Solanki et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Dopamine System Dysregulation in Major Depressive Disorders

(2017) Pauline Belujon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Microbiome-Gut-Brain Axis: Probiotics and Their Association With Depression

(2017) M. Soledad Cepeda et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Depression, telomeres and mitochondrial DNA: between- and within-person associations from a 10-year longitudinal study

(2017) J E Verhoeven et al.   MOLECULAR PSYCHIATRY

Cathepsin C Aggravates Neuroinflammation Involved in Disturbances of Behaviour and Neurochemistry in Acute and Chronic Stress-Induced Murine Model of Depression

(2017) Yanli Zhang et al.   NEUROCHEMICAL RESEARCH

Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise

(2017) Osvaldo C. Moreira et al.   Oxidative Medicine and Cellular Longevity

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

(2017) Konstantinos Palikaras et al.   PHARMACOLOGY & THERAPEUTICS

Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners

(2017) Jung Hwa Ko et al.   Oncotarget

PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson’s Disease Pathobiology?

(2017) Dominika Truban et al.   Journal of Parkinsons Disease

The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex

(2017) Wei Liu et al.   NEURAL PLASTICITY

Evidence Suggesting Absence of Mitochondrial DNA Methylation

(2017) Mie Mechta et al.   Frontiers in Genetics

Mitochondria-targeted antioxidant mitotempo protects mitochondrial function against amyloid beta toxicity in primary cultured mouse neurons

(2016) Hongtao Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Translational regulation of mitochondrial biogenesis

(2016) Y. Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

(2016) Audrey R. Tyrka et al.   BIOLOGICAL PSYCHIATRY

Altered microglia morphology and higher resilience to stress-induced depression-like behavior in CX3CR1-deficient mice

(2016) Sabine Hellwig et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Synaptic Plasticity, Metaplasticity and Depression

(2016) Linnea Vose et al.   Current Neuropharmacology

Mitochondrial Dysfunction in Depression

(2016) Yashika Bansal et al.   Current Neuropharmacology

The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

(2016) Guanglin Qiu et al.   DISEASE MARKERS

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity

(2016) Danielle M. Gerhard et al.   DRUG DISCOVERY TODAY

Impaired mitophagy activates mtROS/HIF-1α interplay and increases cancer aggressiveness in gastric cancer cells under hypoxia

(2016) MASAAKI SHIDA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Dysregulation of the dopamine system in the pathophysiology of schizophrenia and depression

(2016) Anthony A. Grace   NATURE REVIEWS NEUROSCIENCE

Role of Sirtuins in Linking Metabolic Syndrome with Depression

(2016) Juhyun Song et al.   Frontiers in Cellular Neuroscience

Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2016) Ruixue Huang et al.   Nutrients

Increased plasma levels of circulating cell-free mitochondrial DNA in suicide attempters: associations with HPA-axis hyperactivity

(2016) D Lindqvist et al.   Translational Psychiatry

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria

(2015) Gabriele Di Sante et al.   AMERICAN JOURNAL OF PATHOLOGY

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Endosymbiosis and Eukaryotic Cell Evolution

(2015) John M. Archibald   CURRENT BIOLOGY

Editorial (Thematic Selection: A Systematic Review of Depression)

(2015) Ranji Cui   Current Neuropharmacology

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

An Organ System Approach to Explore the Antioxidative, Anti-Inflammatory, and Cytoprotective Actions of Resveratrol

(2015) Ashim Malhotra et al.   Oxidative Medicine and Cellular Longevity

Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression

(2015) Rui Zhou et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Mitochondrial DNA in the regulation of innate immune responses

(2015) Chunju Fang et al.   Protein & Cell

Mitochondria DNA Change and Oxidative Damage in Clinically Stable Patients with Major Depressive Disorder

(2015) Cheng-Chen Chang et al.   PLoS One

BECN1 is involved in the initiation of mitophagy

(2014) Vinay Choubey et al.   Autophagy

VPS35 Parkinson mutation impairs autophagy via WASH

(2014) Eszter Zavodszky et al.   CELL CYCLE

Exercise therapy improves both mental and physical health in patients with major depression

(2014) Jan Knapen et al.   DISABILITY AND REHABILITATION

Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats

(2014) Nelson Escobales et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The role of mTOR in depression and antidepressant responses

(2014) Helena M. Abelaira et al.   LIFE SCIENCES

Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

(2014) Peng Zhong et al.   NEUROPSYCHOPHARMACOLOGY

Leukocyte Mitochondrial DNA Copy Number in Blood Is Not Associated with Major Depressive Disorder in Young Adults

(2014) Ying He et al.   PLoS One

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

(2013) Alessandro Rimessi et al.   Autophagy

Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

(2013) Gaurav Patki et al.   BRAIN RESEARCH

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

Cognitive dysfunction and depression in Fabry disease: a systematic review

(2013) Fay E. Bolsover et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The Psychiatric Presentation of Mitochondrial Disorders in Adults

(2013) Rebecca E. Anglin et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Efficacy of Fasting and Calorie Restriction (FCR) on mood and depression among ageing men

(2013) N. M. Hussin et al.   Journal of Nutrition Health & Aging

Autophagy has a key role in the pathophysiology of schizophrenia

(2013) A Merenlender-Wagner et al.   MOLECULAR PSYCHIATRY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

The Psychiatric Manifestations of Mitochondrial Disorders

(2012) Rebecca E. Anglin et al.   JOURNAL OF CLINICAL PSYCHIATRY

Reduced phosphorylation of the mTOR signaling pathway components in the amygdala of rats exposed to chronic stress

(2012) Agata Chandran et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Oxidative Stress in Schizophrenia

(2011) Iztok Grabnar et al.   Current Neuropharmacology

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Altered sirtuin deacetylase gene expression in patients with a mood disorder

(2011) Naoko Abe et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Psychiatric involvement in adult patients with mitochondrial disease

(2011) Michelangelo Mancuso et al.   NEUROLOGICAL SCIENCES

The relation between depression and parkin genotype: The CORE-PD study

(2011) A. Srivastava et al.   PARKINSONISM & RELATED DISORDERS

Profiling Trait Anxiety: Transcriptome Analysis Reveals Cathepsin B (Ctsb) as a Novel Candidate Gene for Emotionality in Mice

(2011) Ludwig Czibere et al.   PLoS One

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of PGC-1 and Apoε4 in insomnia

(2011) Chien-Chuan Wang et al.   PSYCHIATRIC GENETICS

Abnormalities in Mitochondrial Structure in Cells from Patients with Bipolar Disorder

(2010) Anne M. Cataldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation

(2010) Insil Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

(2010) Moo-Young Kim et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Enhanced Expression of BCL2/Adenovirus EIB 19-kDa-Interacting Protein 3 mRNA, a Candidate for Intrinsic Depression-Related Factor, and Effects of Imipramine in the Frontal Cortex of Stressed Mice

(2010) Michihisa Tohda et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

(2010) Yu Gong et al.   NEUROSCIENCE LETTERS

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Effects of chronic mild stress on the oxidative parameters in the rat brain

(2009) Giancarlo Lucca et al.   NEUROCHEMISTRY INTERNATIONAL

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Mitochondrial turnover in liver is fastin vivoand is accelerated by dietary restriction: application of a simple dynamic model

(2008) Satomi Miwa et al.   AGING CELL

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Mitochondrial Dysfunction and Psychiatric Disorders

(2008) Gislaine T. Rezin et al.   NEUROCHEMICAL RESEARCH

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

(2008) Gislaine T. Rezin et al.   NEUROCHEMISTRY INTERNATIONAL

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA