Late‐in‐life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts

Aging is associated with a decline in Atg9b‐mediated autophagosome formation and appearance of enlarged mitochondria in the heart

(2020) Wenjing Liang et al.   AGING CELL

Fibril formation and therapeutic targeting of amyloid-like structures in a yeast model of adenine accumulation

(2019) Dana Laor et al.   Nature Communications

Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association

(2019) Emelia J. Benjamin et al.   CIRCULATION

Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy

(2018) Shuyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

(2018) Karen Frudd et al.   Nature Communications

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans

(2018) Seul-Ki Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice

(2017) Karla Maria Pires et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy

(2017) Lynn M. DiMemmo et al.   LAB ON A CHIP

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy

(2016) Manabu Taneike et al.   PLoS One

Aldehyde dehydrogenase 2 activation in aged heart improves the autophagy by reducing the carbonyl modification on SIRT1

(2016) Bing Wu et al.   Oncotarget

Untangling Autophagy Measurements: All Fluxed Up

(2015) R. A. Gottlieb et al.   CIRCULATION RESEARCH

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo

(2015) Leena P. Bharath et al.   DIABETES

Hydrogen Sulfide Epigenetically Attenuates Homocysteine-Induced Mitochondrial Toxicity Mediated Through NMDA Receptor in Mouse Brain Endothelial (bEnd3) Cells

(2014) Pradip K. Kamat et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Atg7 Induces Basal Autophagy and Rescues Autophagic Deficiency in CryAB R120G Cardiomyocytes

(2011) J. Scott Pattison et al.   CIRCULATION RESEARCH

Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy

(2011) Andrew J. Boyle et al.   EXPERIMENTAL GERONTOLOGY

Protein homeostasis and aging: The importance of exquisite quality control

(2010) Hiroshi Koga et al.   AGEING RESEARCH REVIEWS

Knockout of insulin receptors in cardiomyocytes attenuates coronary arterial dysfunction induced by pressure overload

(2010) J. David Symons et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Quantitation of "autophagic flux" in mature skeletal muscle

(2010) Jeong-Sun Ju et al.   Autophagy

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Cardiac Aging in Mice and Humans: The Role of Mitochondrial Oxidative Stress

(2010) Dao-Fu Dai et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION