Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration

Oxidative Stress and Hypoxia Modify Mitochondrial Homeostasis During Glaucoma

(2021) Assraa Hassan Jassim et al.   ANTIOXIDANTS & REDOX SIGNALING

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

(2021) Keith E. Campagno et al.   Frontiers in Cellular Neuroscience

Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

(2021) Mariana Y. García-Bermúdez et al.   Frontiers in Neurology

Glucose regulates hypoxia‐induced NLRP3 inflammasome activation in macrophages

(2020) Sachiko Watanabe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

(2020) Thomas O'Loughlin et al.   JOURNAL OF CELL SCIENCE

Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma

(2020) Kazuya Oikawa et al.   MOLECULAR NEUROBIOLOGY

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

(2020) Hui Chen et al.   Molecular Neurodegeneration

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

(2020) Clotilde Lauro et al.   Frontiers in Immunology

Differential Activation of Glioprotective Intracellular Signaling Pathways in Primary Optic Nerve Head Astrocytes after Treatment with Different Classes of Antioxidants

(2020) Anita K. Ghosh et al.   Antioxidants

P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice

(2020) Giovanni Luca Romano et al.   BIOCHEMICAL PHARMACOLOGY

MCT2 overexpression rescues metabolic vulnerability and protects retinal ganglion cells in two models of glaucoma

(2020) Mohammad Harun-Or-Rashid et al.   NEUROBIOLOGY OF DISEASE

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Microglia: Agents of the CNS Pro-Inflammatory Response

(2020) José A. Rodríguez-Gómez et al.   Cells

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

(2020) Danping Zheng et al.   Cell Discovery

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

(2019) Alexey Pronin et al.   Frontiers in Molecular Neuroscience

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve

(2019) Assraa Hassan Jassim et al.   MOLECULAR NEUROBIOLOGY

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine

(2019) Paola Chiozzi et al.   Scientific Reports

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Inducible Rodent Models of Glaucoma

(2019) Iok-Hou Pang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

cGAS‐STING pathway activation in murine retina

(2019) Miao Tang et al.   ACTA OPHTHALMOLOGICA

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

(2019) Csaba Cserép et al.   SCIENCE

Novel Therapeutics in Glaucoma Management

(2018) Claudio Bucolo et al.   Current Neuropharmacology

Modulation of the Immune System for the Treatment of Glaucoma

(2018) Katharina Bell et al.   Current Neuropharmacology

Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome

(2018) Hua Bai et al.   EXPERIMENTAL CELL RESEARCH

Structural and Functional Rescue of Chronic Metabolically Stressed Optic Nerves through Respiration

(2018) Mohammad Harun-Or-Rashid et al.   JOURNAL OF NEUROSCIENCE

Neuroimmflammation and microglia in glaucoma: time for a paradigm shift

(2018) Xin Wei et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Overexpression of parkin protects retinal ganglion cells in experimental glaucoma

(2018) Yi Dai et al.   Cell Death & Disease

Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels

(2018) Jonathan M. Beckel et al.   Scientific Reports

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia

(2018) Mengyu Lai et al.   Frontiers in Aging Neuroscience

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

(2018) Konstantinos Palikaras et al.   NATURE CELL BIOLOGY

Association between Open-Angle Glaucoma and the Risks of Alzheimer’s and Parkinson’s Diseases in South Korea: A 10-year Nationwide Cohort Study

(2018) Jong Youn Moon et al.   Scientific Reports

Inflammatory cytokine profiles in eyes with primary angle-closure glaucoma

(2018) Yayi Wang et al.   BIOSCIENCE REPORTS

Purinergic signaling in the retina: From development to disease

(2018) Ana Lucia Marques Ventura et al.   BRAIN RESEARCH BULLETIN

Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

(2018) Mohammad Harun-Or-Rashid et al.   Journal of Neuroinflammation

Hypoxic expression of NLRP3 and VEGF in cultured retinal pigment epithelial cells: contribution of P2Y2 receptor signaling

(2018) Fabian Doktor et al.   Purinergic Signalling

Biomechanical aspects of axonal damage in glaucoma: A brief review

(2017) Cheri Stowell et al.   EXPERIMENTAL EYE RESEARCH

Biological aspects of axonal damage in glaucoma: A brief review

(2017) Ernst R. Tamm et al.   EXPERIMENTAL EYE RESEARCH

Inflammasomes, the eye and anti-inflammasome therapy

(2017) P Yerramothu et al.   EYE

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

The P2X7 receptor links mechanical strain to cytokine IL-6 up-regulation and release in neurons and astrocytes

(2017) Wennan Lu et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial dysfunction in ocular disease: Focus on glaucoma

(2017) Khalid Kamel et al.   MITOCHONDRION

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma

(2017) C. Gustavo De Moraes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Vitamin B 3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice

(2017) Pete A. Williams et al.   SCIENCE

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

(2017) Farraj Albalawi et al.   Frontiers in Cellular Neuroscience

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

(2017) Nils Lannes et al.   Oncotarget

Use of Anti-VEGF Agents in Glaucoma Surgery

(2017) Mark Slabaugh et al.   Journal of Ophthalmology

Anti-Inflammatory and Antioxidative Stress Effects of Oryzanol in Glaucomatous Rabbits

(2017) Shital S. Panchal et al.   Journal of Ophthalmology

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

(2017) Denise M. Inman et al.   Frontiers in Neuroscience

Mitochondria-meditated pathways of organ failure upon inflammation

(2017) Andrey V. Kozlov et al.   Redox Biology

Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice

(2017) Hélène Cwerman-Thibault et al.   Molecular Therapy-Methods & Clinical Development

Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice

(2017) Frances M. Munoz et al.   Scientific Reports

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy

(2016) Wenxian Wu et al.   Autophagy

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

(2016) Zhenyu Zhong et al.   CELL

Retinal ganglion cell death in glaucoma: Exploring the role of neuroinflammation

(2016) Rossella Russo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

(2016) Małgorzata Nita et al.   Oxidative Medicine and Cellular Longevity

Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective

(2016) Jason C. Lim et al.   Frontiers in Cellular Neuroscience

The Role of the Immune System in Glaucoma: Bridging the Divide Between Immune Mechanisms in Experimental Glaucoma and the Human Disease

(2016) Shivani S. Kamat et al.   Seminars in Ophthalmology

Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma

(2016) Gina N. Wilson et al.   Frontiers in Neuroscience

Retinal Ganglion Cell Loss is Delayed Following Optic Nerve Crush in NLRP3 Knockout Mice

(2016) Zhen Puyang et al.   Scientific Reports

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degeneration

(2016) Myoung Sup Shim et al.   Scientific Reports

Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses

(2015) Anne D. Cherry et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Toll-like receptor-4 knockout mice are more resistant to optic nerve crush damage than wild-type mice

(2015) Dana Morzaev et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma

(2015) A. Bosco et al.   Disease Models & Mechanisms

Animal models of glucocorticoid-induced glaucoma

(2015) Darryl R. Overby et al.   EXPERIMENTAL EYE RESEARCH

Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities

(2015) Kimberly A. Fernandes et al.   EXPERIMENTAL EYE RESEARCH

Mitochondrial Morphology Differences and Mitophagy Deficit in Murine Glaucomatous Optic Nerve

(2015) L. Coughlin et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Microglia and neuroprotection

(2015) Zhihong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma

(2015) Gina N. Wilson et al.   Journal of Neuroinflammation

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma

(2015) Ji-hong Wu et al.   NEUROBIOLOGY OF DISEASE

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach

(2015) Chiara B. M. Platania et al.   Frontiers in Pharmacology

Purines in the eye: Recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland

(2014) Julie Sanderson et al.   EXPERIMENTAL EYE RESEARCH

Mechanosensitive release of adenosine 5′-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: A mechanism for purinergic involvement in chronic strain

(2014) Jonathan M. Beckel et al.   GLIA

Microglia in mouse retina contralateral to experimental glaucoma exhibit multiple signs of activation in all retinal layers

(2014) Blanca Rojas et al.   Journal of Neuroinflammation

Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset

(2014) Jeffrey M. Gidday et al.   Neurotherapeutics

Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040

(2014) Yih-Chung Tham et al.   OPHTHALMOLOGY

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma

(2014) Christine M. Dengler-Crish et al.   Frontiers in Neuroscience

Regulation of intraocular pressure in mice: Structural analysis of dopaminergic and serotonergic systems in response to cabergoline

(2013) Chiara Bianca Maria Platania et al.   BIOCHEMICAL PHARMACOLOGY

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

(2013) Naeha Subramanian et al.   CELL

Mitochondrial Dysfunction Indirectly Elevates ROS Production by the Endoplasmic Reticulum

(2013) Michael P. Murphy   Cell Metabolism

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death

(2013) Noriko Himori et al.   JOURNAL OF NEUROCHEMISTRY

P2X7 Receptor Activation Induces Reactive Oxygen Species Formation and Cell Death in Murine EOC13 Microglia

(2013) Rachael Bartlett et al.   MEDIATORS OF INFLAMMATION

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

ATP release and purinergic signaling in NLRP3 inflammasome activation

(2013) Aurélie Gombault et al.   Frontiers in Immunology

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma

(2012) Alejandra Bosco et al.   PLoS One

Critical pathogenic events underlying progression of neurodegeneration in glaucoma

(2012) David J. Calkins   PROGRESS IN RETINAL AND EYE RESEARCH

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

Dopamine-3 receptor modulates intraocular pressure: Implications for glaucoma

(2011) Claudio Bucolo et al.   BIOCHEMICAL PHARMACOLOGY

Sustained elevation of extracellular ATP in aqueous humor from humans with primary chronic angle-closure glaucoma

(2011) Ang Li et al.   EXPERIMENTAL EYE RESEARCH

Structural basis of glaucoma: The fortified astrocytes of the optic nerve head are the target of raised intraocular pressure

(2011) Chao Dai et al.   GLIA

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

(2011) Gareth R. Howell et al.   JOURNAL OF CLINICAL INVESTIGATION

Carbon monoxide and the eye: Implications for glaucoma therapy

(2011) Claudio Bucolo et al.   PHARMACOLOGY & THERAPEUTICS

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

The immune response in glaucoma: A perspective on the roles of oxidative stress

(2010) Gülgün Tezel   EXPERIMENTAL EYE RESEARCH

Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies

(2010) Shanjean Lee et al.   EXPERIMENTAL EYE RESEARCH

Ageing alters the supramolecular architecture of OxPhos complexes in rat brain cortex

(2010) Monika Frenzel et al.   EXPERIMENTAL GERONTOLOGY

Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss

(2010) Janice L. Son et al.   GLIA

Early microglia activation in a mouse model of chronic glaucoma

(2010) Alejandra Bosco et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Modulation of mitochondria in the axon and soma of retinal ganglion cells in a rat glaucoma model

(2010) Yasunari Munemasa et al.   JOURNAL OF NEUROCHEMISTRY

Effects of mitochondrial dysfunction on the immunological properties of microglia

(2010) Annette I Ferger et al.   Journal of Neuroinflammation

Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration

(2010) S. Baltan et al.   JOURNAL OF NEUROSCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

Mitochondrial Dysfunction and Glaucoma

(2009) George Y. X. Kong et al.   JOURNAL OF GLAUCOMA

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES

A water-soluble carbon monoxide-releasing molecule (CORM-3) lowers intraocular pressure in rabbits

(2008) E Stagni et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand

(2008) M. B. Wax et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels

(2008) D. Reigada et al.   NEUROSCIENCE

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The P2X7 receptor in retinal ganglion cells: A neuronal model of pressure-induced damage and protection by a shifting purinergic balance

(2008) Claire H. Mitchell et al.   Purinergic Signalling