Article
Dentistry, Oral Surgery & Medicine
Qingyuan Ye, Haokun Xu, Shiyu Liu, Zihan Li, Jun Zhou, Feng Ding, Xige Zhang, Yazheng Wang, Yan Jin, Qintao Wang
Summary: The study discovered that apoptotic extracellular vesicles (ApoEVs) can inhibit macrophages from polarizing into proinflammatory phenotypes via the AMPK/SIRT1/NF-kappa B pathway, and also suppress nearby osteoclast formation by reducing the secretion of TNF-alpha. This provides a new approach for the treatment of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mustafa Yilmaz, Esra Demir, Mervi Gursoy, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-gamma, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio. The study found that IL-10, CD163, and TWEAK levels were higher in periodontally healthy tissues than in periodontitis tissues. Pocket closure at 12 weeks was associated with elevated baseline gingival CD163 levels and CD163/TWEAK ratio.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Immunology
Weimin Fan, Shixian Chen, Xianghui Wu, Junqing Zhu, Juan Li
Summary: The study demonstrates that resveratrol significantly improves gouty arthritis by inhibiting the activation of NLRP3 inflammasomes through promoting mitophagy.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ondrej Heneberk, Eliska Wurfelova, Vladimira Radochova
Summary: Neopterin is a biomarker that indicates the activation of cellular immunity. This review discusses neopterin metabolism, detection methods, and its role in inflammation, with a focus on periodontal inflammatory diseases. Neopterin is a non-enzymatic product of 7,8-dihydroneopterin oxidation caused by free radicals, protecting activated macrophages from oxidative stress. Various methods, such as enzyme-linked immunosorbent assay, high-performance liquid chromatography, and radioimmunoassay, have been developed to detect neopterin. Neopterin levels are affected by various diseases, including cardiovascular, bacterial, viral, degenerative diseases, and malignant tumors. In periodontitis, neopterin levels increase, particularly in the gingival crevicular fluid and oral fluid, highlighting the role of activated macrophages and cellular immunity. Nonsurgical periodontal treatment can decrease neopterin levels, but an increase may also be observed, suggesting the involvement of macrophages in the resolution of periodontal lesions.
Article
Dentistry, Oral Surgery & Medicine
N. Da Ponte Leguizamon, R. S. de Molo, G. Coletto-Nunes, A. V. B. Nogueira, S. Rocha, D. M. Neo-Justino, A. Soares-Costa, P. S. Cerri, U. H. Lerner, P. P. C. Souza, J. A. Cirelli
Summary: CsinCPI-2 inhibits inflammatory processes and alveolar bone loss caused by periodontal disease, as well as directly affecting osteoclastogenesis. In mice models, CsinCPI-2 significantly reduces inflammatory cell infiltration and prevents alveolar bone loss, offering potential for periodontal disease treatment.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ren-Yeong Huang, Hua-Yang Chang, Shu-Mi Chih, Thomas Van Dyke, Chia-Dan Cheng, Cheng-En Sung, Pei-Wei Weng, Yi-Shing Shieh, Wan-Chien Cheng
Summary: The study found that silibinin can effectively reduce periodontitis-induced bone loss, decrease gingival inflammation and RANKL expression. Silibinin inhibits the differentiation and function of inflammatory cells and osteoclasts, thereby inhibiting inflammation-induced bone loss.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. S. Zhang, C. X. Jiang, Y. T. Ji, Y. F. Zhang, Z. Chen, Z. G. Cao, H. Liu
Summary: The Mir338 cluster is significantly enriched in gingival tissues with periodontitis and plays a role in both inflammation and alveolar bone loss. Knockout of the Mir338 cluster in mice attenuates alveolar bone loss and affects macrophage polarization and osteoclast formation. The Mir338 cluster could be a potential therapeutic target for periodontitis-related bone loss.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jorge F. Lima Teixeira, Petra Henning, Fernando A. Cintra Magalhaes, Glaucia Coletto-Nunes, Thais Floriano-Marcelino, Anna Westerlund, Sofia Moverare-Skrtic, Guilherme J. P. L. Oliveira, Ulf H. Lerner, Pedro Paulo C. Souza
Summary: This study found that interleukin-4 (IL-4) can reduce lipoprotein-induced periodontal bone loss through multiple mechanisms, including direct inhibition of osteoclast progenitors, decreased expression of osteoclast-regulating cytokines in osteoblasts, and decreased inflammation.
Article
Cardiac & Cardiovascular Systems
Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A. Mesarwi, Klaus Ley, Brendan Gongol, Miguel Alejandro Lopez-Ramirez
Summary: This study investigates the interaction between CCM endothelium, astrocytes, leukocytes, microglia/macrophages, and neutrophils during the pathogenesis of cerebral cavernous malformations (CCMs) in brain tissue. The results reveal a novel gene signature for neuroinflammatory astrocytes and identify crucial genes involved in recruiting inflammatory cells and thrombus formation in CCM lesions. It also suggests that therapeutic approaches targeting brain endothelial NF-kappa B activity may have detrimental side effects.
CIRCULATION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Haiyan Han, Lixin Zhang, Qiang Fu, Biqin Zhang, Jiaxiu Chen
Summary: Obesity may worsen the severity of pancreatitis by increasing serum lipase, non-esterified fatty acids, and myeloperoxidase levels, activating M1 polarization in adipose tissue macrophages, and elevating pro-inflammatory cytokines. Moreover, serum exosomes may modulate the expression of inflammatory factors in THP-1 cells, affecting the development of pancreatitis. These findings contribute to a better understanding of the relationship between obesity and pancreatitis and the underlying mechanisms.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
K. H. Kwack, L. Zhang, J. Sohn, V Maglaras, R. Thiyagarajan, K. L. Kirkwood
Summary: The study suggests that expansion of myeloid-derived suppressor cells (MDSCs) in obese mice may contribute to the formation of osteoclasts during periodontitis, leading to increased alveolar bone destruction. This provides a more detailed mechanistic understanding of the interplay between obesity and periodontitis.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Cell & Tissue Engineering
Ji-Won Lee, In-Hee Lee, Tadahiro Iimura, Sek Won Kong
Summary: Tissue-resident macrophages are highly specialized to specific tissue microenvironments, influenced by inflammatory signals, genetics, and environment. Osteoclasts and microglia in bone and brain are responsible for pathological changes in osteoporosis and AD, with osteoporosis more common in individuals with AD. Earlier diagnosis and intervention for those at higher risk could modify clinical courses. The Pyk2-mediated actin polymerization pathway is identified as a horizontal pleiotropic mediator of shared risk factors for osteoporosis and AD.
Article
Cell Biology
Noushin Saljoughian Esfahani, Qian Wu, Naresh Kumar, Latha Prabha Ganesan, William P. Lafuse, Murugesan V. S. Rajaram
Summary: Aging affects the phenotype and function of cardiac immune cells, leading to immune dysregulation and cardiac electrical dysfunction during infection in aged mice.
Article
Dentistry, Oral Surgery & Medicine
Winita Suwanprasit, Attawood Lertpimonchai, Lalitsara Thienpramuk, Prin Vathesatogkit, Piyamitr Sritara, Suphot Tamsailom
Summary: There is a significant association between MetS and severe periodontitis in Thai adults, with age acting as a modifier of this relationship.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Engineering, Biomedical
Wanli Chen, Weiwei Xiao, Xuzheng Liu, Pingping Yuan, Siqian Zhang, Yinggang Wang, Wei Wu
Summary: This study found that macrophage autophagy decreased with aging, leading to aggravated inflammation and poor vascular remodeling of artificial grafts. Pharmacological manipulation of macrophage autophagy was shown to promote macrophage polarization and biomaterial degradation, facilitating vascular regeneration.
BIOACTIVE MATERIALS
(2022)