Article
Multidisciplinary Sciences
Vishwa Deepak, Shu-Ting Yang, Ziqing Li, Xinhua Li, Andrew Ng, Ding Xu, Yi-Ping Li, Merry Jo Oursler, Shuying Yang
Summary: This study identifies a negative function of IFT80 in osteoclasts by regulating the stabilization and degradation of Cbl-b and TRAF6, thereby affecting osteoclast formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Medicine, Research & Experimental
Yaosheng Xiao, Xunlu Xie, Zhixi Chen, Guoqiang Yin, Weihao Kong, Jianguo Zhou
Summary: ATF4 plays a crucial role in maintaining bone homeostasis and inhibiting the development of osteoporosis. It promotes bone formation and inhibits bone resorption.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Tatjana Bordukalo-Niksic, Vera Kufner, Slobodan Vukicevic
Summary: Bone remodeling in the adult skeleton involves a continuous process of old and damaged bone removal by osteoclasts and subsequent new bone formation by osteoblasts. BMPs play a crucial role in maintaining healthy bone, affecting both bone formation and resorption, and may be involved in pathological processes related to inflammatory disorders affecting bones and joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Priyanka Ramesh, Rahul Jagadeesan, Saravanan Sekaran, Anuradha Dhanasekaran, Selvaraj Vimalraj
Summary: Flavonoids are polyphenolic compounds found in various natural products with multiple applications, including anti-inflammatory, anti-oxidative, and anti-carcinogenic properties, as well as the ability to stimulate bone formation. They influence bone remodelling through various signaling pathways and play a crucial role in maintaining bone integrity and structure. Their effects on regulating angiogenesis, decreasing inflammatory cytokine levels, and scavenging reactive oxygen species further underscore their potential as a promising agent in treating bone-related ailments in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell & Tissue Engineering
Xiankun Cao, Wenxin He, Kewei Rong, Shenggui Xu, Zhiqian Chen, Yuwei Liang, Shuai Han, Yifan Zhou, Xiao Yang, Hui Ma, An Qin, Jie Zhao
Summary: This study revealed that DZNep enhances osteoblast differentiation and mineralization through the EZH2-H3K27me3-Wnt4 axis, while also promotes osteoclast formation via the EZH2-H3K27me3-Foxc1 axis. This enhanced osteogenesis and osteoclastogenesis resulted in accelerated bone defect healing in mice.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Engineering, Environmental
Yonggang Ma, Di Ran, Ying Cao, Hongyan Zhao, Ruilong Song, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Jiaqiao Zhu, Zongping Liu
Summary: Long-term exposure to cadmium inhibits osteogenesis of bone marrow stem cells and differentiation of bone marrow macrophages, leading to osteoporosis. P2X7 plays a crucial role in this process, with its deletion or overexpression affecting bone cell differentiation. Short-term exposure to cadmium inhibits bone formation, increases osteoclast numbers, but does not result in osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Endocrinology & Metabolism
Pan Sun, Tingrui Huang, Chen Huang, Yongjun Wang, Dezhi Tang
Summary: Osteoporosis is a degenerative bone disease characterized by reduced bone mass and damage to bone microarchitecture, leading to increased bone fragility and susceptibility to fractures. The risk of osteoporosis increases with age, and it is becoming more prevalent due to the aging global population. Histone modifications play an important role in the occurrence and development of osteoporosis, and targeting these modifications to promote bone formation may be an effective treatment strategy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Mariya Stavnichuk, Svetlana Komarova
Summary: Multiple studies have shown reciprocal communications between bone marrow hematopoiesis and bone remodeling processes, with megakaryocytes playing a role in bone homeostasis. The effects of megakaryocytes on bone cells are influenced by the age and sex of animals, and they stimulate osteoblast proliferation while having variable effects on osteoclast proliferation and activity through soluble factors and direct cell-cell communications.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Geriatrics & Gerontology
Bingzi Dong, Jingjing Zhu, Xian Chen, Hongyuan Jiang, Yujie Deng, Lili Xu, Yangang Wang, Shufa Li
Summary: IL-11 is a cytokine involved in hematopoiesis, cancer metastasis, and inflammation. It enhances bone formation and mitigates bone resorption and cancer bone metastasis. IL-11 deficiency leads to reduced bone mass and formation, adiposity, glucose intolerance, and insulin resistance. Thus, IL-11 plays a vital role in bone homeostasis and could be a potential therapeutic strategy.
Review
Medicine, General & Internal
Sajad Chamani, Luca Liberale, Leila Mobasheri, Fabrizio Montecucco, Khalid Al-Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Statins not only reduce LDL-C levels, but also have regulatory effects on bone metabolism, increasing bone formation and improving bone density. Therefore, statins may play a role in the treatment of bone disorders.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I. Idris
Summary: Research on the modulation of CB1 and CB2 receptors on bone metabolism has shown that the results are confounded by the heterogeneity of models and the low number of studies.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Cell Biology
Tang Qi, Liao Li, Tian Weidong
Summary: Research on bioactive lipids, specifically sphingolipids and their metabolites, has revealed their important role in skeletal remodeling and cellular functions like the interaction between osteoblasts and osteoclasts. Understanding the crosstalk between sphingomyelin, ceramide, and S1P in the sphingolipid family provides potential therapeutic options for bone diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ankita Agrawal, Niklas R. Jorgensen
Summary: Maintaining a healthy skeleton relies on a complex regulation of bone metabolism, where physiological release of purines through purinoceptors plays a crucial role. Derivatives of adenosine released by bone cells are influenced by various factors such as mechanical loading, systemic hormones, and pathological conditions.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Yue Hu, Xinqing Hao, Cangwei Liu, Chunxia Ren, Shuangshuang Wang, Guangxing Yan, Yuan Meng, Yuji Mishina, Ce Shi, Hongchen Sun
Summary: The study showed that deletion of Acvr1 in the mandible leads to bone loss, mainly due to compromised osteoblast differentiation and enhanced osteoclastogenesis. In vitro experiments demonstrated that Acvr1 deficiency in mandibular bone marrow stromal cells resulted in increased proliferation and differentiation of osteoclasts. Additionally, the increased osteoclastogenesis may be partially attributed to the secretion of sRANKL.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Respiratory System
Julien Braux, Marie-Laure Jourdain, Christine Guillaume, Valerie Untereiner, Olivier Piot, Andrea Baehr, Nikolai Klymiuk, Nathalie Winter, Mustapha Berri, Dominique Buzoni-Gatel, Ignaccio Caballero, Antoine Guillon, Mustapha Si-Tahar, Jacky Jacquot, Frederic Velard
JOURNAL OF CYSTIC FIBROSIS
(2020)
Article
Multidisciplinary Sciences
Frederic Velard, Aurore Chatron-Colliet, Dominique Come, Marie-Dominique Ah-Kioon, Hilene Lin, Narjes Hafsia, Martine Cohen-Solal, Hang-Korng Ea, Frederic Liote
SCIENTIFIC REPORTS
(2020)
Article
Polymer Science
Xing Liu, Adrien Baldit, Emilie de Brosses, Frederic Velard, Ghislaine Cauchois, Yun Chen, Xiong Wang, Natalia de Isla, Cedric Laurent
Article
Biochemistry & Molecular Biology
Marie-Laure Jourdain, Johan Sergheraert, Julien Braux, Christine Guillaume, Sophie C. Gangloff, Dominique Hubert, Frederic Velard, Jacky Jacquot
Summary: The F508del mutation in CF patients may affect the osteoclastogenesis and bone-resorptive abilities of osteoclasts, resulting in low bone mineral density. Experimental comparisons showed that OCs with the F508del mutation had severe differentiation defects and high S1P release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Physiology
Soula Danopoulos, Gail H. Deutsch, Claire Dumortier, Thomas J. Mariani, Denise Al Alam
Summary: Down syndrome is a common chromosomal abnormality with respiratory failure and lung disease being the leading causes of morbidity and mortality.Understanding the different lung phenotypes and genetic pathways associated with DS can help in managing complications related to respiratory illness.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Manon Doue, Anais Okwieka, Alexandre Berquand, Laetitia Gorisse, Pascal Maurice, Frederic Velard, Christine Terryn, Michael Molinari, Laurent Duca, Christine Pietrement, Philippe Gillery, Stephane Jaisson
Summary: The study found that vascular elastic fibers can undergo carbamylation, leading to an increase in stiffness that may affect the mechanical properties of the vascular wall, thereby being associated with aortic stiffness and the development of cardiovascular diseases.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Fabien Lamret, Jennifer Varin-Simon, Frederic Velard, Christine Terryn, Celine Mongaret, Marius Colin, Sophie C. Gangloff, Fany Reffuveille
Summary: Staphylococcus aureus poses a significant threat in hospital healthcare, often forming biofilms on medical devices like bone and joint prostheses leading to treatment failure. Different strains of S. aureus exhibit varying responses in a bone-like environment, but share common traits of producing extracellular DNA and engaging in the SOS response. This study sheds light on potential common targets for antibiofilm strategies against S. aureus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Christina Maillet, Serge Odof, Mikael Meuret, Florian Le Bras, Frederic Velard, Marie-Paule Gelle
Summary: The low-pressure non-thermal O-2 plasma treatment significantly reduced the viability of C. albicans and caused major alterations in yeasts after 120 minutes of treatment. Minor color changes in the resin were observed only after six plasma treatments, but they remained below the acceptable threshold for denture aesthetics.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Aurelie Moniot, Julien Braux, Camille Bour, Christine Guillaume, Fabien Lamret, Ingrid Allart-Simon, Sandra Audonnet, Sarah Renault, Francoise Redini, Marie Laronze-Cochard, Janos Sapi, Sophie C. Gangloff, Stephane Gerard, Frederic Velard
Summary: Novel pyridazinone derivatives have shown potential as anti-osteosarcoma therapeutics, with cytotoxic activity in vitro and the ability to limit tumor growth in a murine orthotopic osteosarcoma model. These compounds may provide a new avenue for developing therapeutic strategies against osteosarcoma.
Article
Biochemistry & Molecular Biology
Aurelie Moniot, Julien Braux, Renaud Siboni, Christine Guillaume, Sandra Audonnet, Ingrid Allart-Simon, Janos Sapi, Rabindra Tirouvanziam, Stephane Gerard, Sophie C. Gangloff, Frederic Velard
Summary: In inflammatory diseases, the excessive activation of polymorphonuclear neutrophils (PMNs) can lead to tissue damage. This study investigated the effects of two novel compounds, 4aa and 4ba, on PMNs activation and found that they can reduce the release of inflammatory cytokines, decrease PMNs phagocytic ability, and limit the recruitment of PMNs in tissues. These findings suggest the therapeutic potential of these compounds in the treatment of inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabien Lamret, Jennifer Varin-Simon, Melodie Six, Lea Thoraval, Julie Chevrier, Cloe Adam, Christine Guillaume, Frederic Velard, Sophie C. Gangloff, Fany Reffuveille
Summary: Osteoblasts and Staphylococcus aureus interactions can lead to impaired bone homeostasis. This study found that human osteoblast culture supernatant has a moderate effect on S. aureus biofilm formation, but does not significantly change the biofilm matrix or regulation of biofilm-related genes. Additionally, the sensitivity of S. aureus to bone cell secretions is strain-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Anais Lemaire, Jennifer Varin-Simon, Fabien Lamret, Marie Dubus, Halima Kerdjoudj, Frederic Velard, Sophie C. Gangloff, Fany Reffuveille
Summary: Infections are a critical issue during the development of biomimetic materials for bone regeneration. Calcium phosphate and collagen substrates may favor bacterial adhesion. Staphylococcus aureus possesses adhesins that allow binding to these substrates, leading to the development of biofilms highly tolerant to immune system attacks or antibiotic treatments. Therefore, choosing the right material for bone substitutes is crucial to prevent bacterial adhesion and reduce the risk of bone and joint infections.
Article
Biochemistry & Molecular Biology
Ingrid Allart-Simon, Aurelie Moniot, Nicolo Bisi, Miguel Ponce-Vargas, Sandra Audonnet, Marie Laronze-Cochard, Janos Sapi, Eric Henon, Frederic Velard, Stephane Gerard
Summary: This study describes the development and characterization of pyridazinone derivatives as potential PDE4 inhibitors for anti-inflammatory therapy. Among these derivatives, one compound showed promising activity and selectivity towards PDE4B isoenzymes, regulating potent pro-inflammatory cytokine and chemokine production by human primary macrophages.
RSC MEDICINAL CHEMISTRY
(2021)