The Phosphorylated Form of the Histone H2AX (γH2AX) in the Brain from Embryonic Life to Old Age

TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage

(2021) Pei Liu et al.   NEUROCHEMICAL RESEARCH

Spatiotemporal dynamics of γH2AX in the mouse brain after acute irradiation at different postnatal days with special reference to the dentate gyrus of the hippocampus

(2021) Feng Ru Tang et al.   Aging-US

SUMOylated Senataxin functions in genome stability, RNA degradation, and stress granule disassembly, and is linked with inherited ataxia and motor neuron disease

(2021) Craig L. Bennett et al.   Molecular Genetics & Genomic Medicine

Association of Caspase 3 Activation and H2AX γ Phosphorylation in the Aging Brain: Studies on Untreated and Irradiated Mice

(2021) Nadia Gionchiglia et al.   Biomedicines

Disruption of postnatal neurogenesis and adult-stage suppression of synaptic plasticity in the hippocampal dentate gyrus after developmental exposure to sterigmatocystin in rats

(2021) Kazumi Takashima et al.   TOXICOLOGY LETTERS

Inter- and intraspecies comparison of phylogenetic fingerprints and sequence diversity of immunoglobulin variable genes

(2020) Alexander Yermanos et al.   IMMUNOGENETICS

Cellular senescence and Alzheimer disease: the egg and the chicken scenario

(2020) Sara Saez-Atienzar et al.   NATURE REVIEWS NEUROSCIENCE

Paraquat increases Interleukin-1β in hippocampal dentate gyrus to impair hippocampal neurogenesis in adult mice

(2020) Qian Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain

(2020) Michal P. Jurkowski et al.   Frontiers in Cellular Neuroscience

Cytosine arabinoside induces phosphorylation of histone H2AX in hippocampal neurons via a noncanonical pathway

(2020) Saki Nakayama et al.   NEUROCHEMISTRY INTERNATIONAL

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

(2020) Meihua Piao et al.   Frontiers in Cellular Neuroscience

Adult neurogenesis promotes balance recovery after vestibular loss

(2019) Brahim Tighilet et al.   PROGRESS IN NEUROBIOLOGY

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis

(2019) Urbain Weyemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Flow Cytometry Quantifies Neural Genome Dynamics

(2019) Nadine Michel et al.   CYTOMETRY PART A

Expression of p16 and p21 in the frontal association cortex of ALS / MND brains suggest neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease

(2019) Irina Vazquez‐Villaseñor et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Early neuronal accumulation of DNA double strand breaks in Alzheimer’s disease

(2019) Niraj M. Shanbhag et al.   Acta Neuropathologica Communications

Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation

(2019) Xuyang Yao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the Immune System in the Development of the Central Nervous System

(2019) Keiko Morimoto et al.   Frontiers in Neuroscience

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

(2019) Elena Martín-Doncel et al.   Scientific Reports

Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability

(2019) Yanqiang Zhan et al.   NEUROSCIENCE

RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth

(2019) Noemí Álvarez-Lindo et al.   Scientific Reports

DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice

(2019) Margaret M. Loniewska et al.   Redox Biology

The relationship between DNA single-stranded damage response and double-stranded damage response

(2018) Aiqing Ma et al.   CELL CYCLE

γH2AX is increased in peripheral blood lymphocytes of Alzheimer’s disease patients in the South Australian Neurodegeneration, Nutrition and DNA Damage (SAND) study of aging

(2018) Mohammad Sabbir Siddiqui et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cypermethrin: Oxidative stress and genotoxicity in retinal cells of the adult zebrafish

(2018) E.V. Paravani et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Comparative review of adult midbrain and striatum neurogenesis with classical neurogenesis

(2018) Parisa Farzanehfar   NEUROSCIENCE RESEARCH

Altered DNA repair; an early pathogenic pathway in Alzheimer’s disease and obesity

(2018) Hao Yu et al.   Scientific Reports

“Till Death Do Us Part”: A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in the Adult Olfactory Bulb

(2018) Saad Omais et al.   Frontiers in Neuroscience

OUP accepted manuscript

(2018)   JOURNAL OF RADIATION RESEARCH

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

(2018) Chiara Milanese et al.   Cell Death & Disease

Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA

(2018) Jorge Mata-Garrido et al.   Acta Neuropathologica Communications

Caspase-3 Mediated Cell Death in the Normal Development of the Mammalian Cerebellum

(2018) Laura Lossi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nucleosome structure and dynamics are coming of age

(2018) Keda Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neural Progenitor Cell Terminology

(2018) Verónica Martínez-Cerdeño et al.   Frontiers in Neuroanatomy

Insights Into SND1 Oncogene Promoter Regulation

(2018) Begoña Ochoa et al.   Frontiers in Oncology

Development and aging of a brain neural stem cell niche

(2017) Joanne C Conover et al.   EXPERIMENTAL GERONTOLOGY

The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis

(2017) Manal A. Farg et al.   HUMAN MOLECULAR GENETICS

The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

(2017) Edward Fielder et al.   JOURNAL OF ALZHEIMERS DISEASE

Telomere-driven diseases and telomere-targeting therapies

(2017) Paula Martínez et al.   JOURNAL OF CELL BIOLOGY

Senataxin: Genome Guardian at the Interface of Transcription and Neurodegeneration

(2017) Matthias Groh et al.   JOURNAL OF MOLECULAR BIOLOGY

Genome instability in Alzheimer disease

(2017) Yujun Hou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Alternative Chk1-independent S/M checkpoint in somatic cells that prevents premature mitotic entry

(2017) Doaa Hussein Zineldeen et al.   MEDICAL ONCOLOGY

gamma-H2AX: Can it be established as a classical cancer prognostic factor?

(2017) Viktoria-Varvara Palla et al.   TUMOR BIOLOGY

Cell death and neurodegeneration in the postnatal development of cerebellar vermis in normal and Reeler mice

(2016) Claudia Castagna et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Natural apoptosis in developing mice dopamine midbrain neurons and vermal Purkinje cells

(2016) Joaquín Martí-Clúa   FOLIA NEUROPATHOLOGICA

Radial derivatives of the mouse ventral pallium traced with Dbx1-LacZ reporters

(2016) Luis Puelles et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Developmental gene expression in the mouse clarifies the organization of the claustrum and related endopiriform nuclei

(2016) Charles Watson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson’s disease

(2016) Andrew R Cook et al.   LABORATORY INVESTIGATION

Role of FET proteins in neurodegenerative disorders

(2016) Francesca Svetoni et al.   RNA Biology

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis

(2016) Midori Shimada et al.   Nature Communications

Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum

(2016) Vijay Swahari et al.   Cell Reports

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

(2016) Darryl Hudson et al.   Aging-US

Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells

(2016) Mathieu Daynac et al.   Scientific Reports

Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus

(2016) Zhi-Yong He et al.   Scientific Reports

Persistent γH2AX: A promising molecular marker of DNA damage and aging

(2015) Mohammad Sabbir Siddiqui et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Genomic integrity and the ageing brain

(2015) Hei-man Chow et al.   NATURE REVIEWS NEUROSCIENCE

Chronic Alcohol Exposure Decreases 53BP1 Protein Levels Leading to a Defective DNA Repair in Cultured Primary Cortical Neurons

(2015) Ana M. Romero et al.   NEUROTOXICITY RESEARCH

Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions

(2015) Valentina Turinetto et al.   NUCLEIC ACIDS RESEARCH

Cellular commitment in the developing cerebellum

(2015) Hassan Marzban et al.   Frontiers in Cellular Neuroscience

A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response

(2014) Roman Alpatov et al.   CELL

Histone Variant H2A.X Deposition Pattern Serves as a Functional Epigenetic Mark for Distinguishing the Developmental Potentials of iPSCs

(2014) Tao Wu et al.   Cell Stem Cell

The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases

(2014) Stéphanie Solier et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

(2014) Andrew M. Tidball et al.   HUMAN MOLECULAR GENETICS

Phosphorylation of Histone H2AX in the Mouse Brain from Development to Senescence

(2014) Serena Barral et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interplay between the DNA Damage Proteins MDC1 and ATM in the Regulation of the Spindle Assembly Checkpoint

(2014) Yifat Eliezer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FUS is Phosphorylated by DNA-PK and Accumulates in the Cytoplasm after DNA Damage

(2014) Q. Deng et al.   JOURNAL OF NEUROSCIENCE

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort

(2014) Claire J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

2, 3, 7, 8-Tetrachlorodibenzo-P-Dioxin (TCDD) Induces Premature Senescence in Human and Rodent Neuronal Cells via ROS-Dependent Mechanisms

(2014) Chunhua Wan et al.   PLoS One

Repair of Oxidative DNA Damage, Cell-Cycle Regulation and Neuronal Death May Influence the Clinical Manifestation of Alzheimer’s Disease

(2014) Aderbal R. T. Silva et al.   PLoS One

Role of the DNA Base Excision Repair Protein, APE1 in Cisplatin, Oxaliplatin, or Carboplatin Induced Sensory Neuropathy

(2014) Mark R. Kelley et al.   PLoS One

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions

(2014) Marie Violet et al.   Frontiers in Cellular Neuroscience

Preferential localization of γH2AX foci in euchromatin of retina rod cells after DNA damage induction

(2013) Laura Lafon-Hughes et al.   CHROMOSOME RESEARCH

Neuronal cytotoxicity and genotoxicity induced by zinc oxide nanoparticles

(2013) Vanessa Valdiglesias et al.   ENVIRONMENT INTERNATIONAL

Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity

(2013) Kenya Yuki et al.   EXPERIMENTAL EYE RESEARCH

γH2AX foci formation in the absence of DNA damage: Mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway

(2013) Wen-Zhi Tu et al.   FEBS LETTERS

Studying the cerebellar DNA damage response in the tissue culture dish

(2013) Aya Tzur-Gilat et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration

(2013) Dorothee Dormann et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Exposure of insect cells to ionising radiation in vivo induces persistent phosphorylation of a H2AX homologue (H2AvB)

(2013) M. S. Siddiqui et al.   MUTAGENESIS

Double strand break repair functions of histone H2AX

(2013) Ralph Scully et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

(2013) Elsa Suberbielle et al.   NATURE NEUROSCIENCE

Effects of DSP4 on the Noradrenergic Phenotypes and Its Potential Molecular Mechanisms in SH-SY5Y Cells

(2013) Yan Wang et al.   NEUROTOXICITY RESEARCH

Phosphorylated histone H2A.x in porcine embryos produced by IVF and somatic cell nuclear transfer

(2013) Rodrigo C Bohrer et al.   REPRODUCTION

Aging in the olfactory system

(2013) Arie S. Mobley et al.   TRENDS IN NEUROSCIENCES

Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma

(2012) Z. Deng et al.   JOURNAL OF CELL SCIENCE

Spatiotemporal Changes to the Subventricular Zone Stem Cell Pool through Aging

(2012) B. A. Shook et al.   JOURNAL OF NEUROSCIENCE

Deregulation of BRCA1 Leads to Impaired Spatiotemporal Dynamics of γ-H2AX and DNA Damage Responses in Huntington’s Disease

(2012) Gye Sun Jeon et al.   MOLECULAR NEUROBIOLOGY

Beyond Repair Foci: DNA Double-Strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy

(2012) Yvonne Lorat et al.   PLoS One

High Basal γH2AX Levels Sustain Self-Renewal of Mouse Embryonic and Induced Pluripotent Stem Cells

(2012) Valentina Turinetto et al.   STEM CELLS

Molecular Control of Neurogenesis: A View from the Mammalian Cerebral Cortex

(2012) B. Martynoga et al.   Cold Spring Harbor Perspectives in Biology

Chk1 has an essential role in the survival of differentiated cortical neurons in the absence of DNA damage

(2011) Weizhen Ye et al.   APOPTOSIS

LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress

(2011) Gianfranco Giorgi et al.   CELL AND TISSUE RESEARCH

Activation of DNA damage response signaling in mouse embryonic stem cells

(2011) Ilya A. Chuykin et al.   CELL CYCLE

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

Pseudo-DNA damage response in senescent cells

(2011) Tatyana V. Pospelova et al.   CELL CYCLE

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway

(2011) Wei Yan et al.   FEBS LETTERS

Investigation of the Functional Link betweenATMandNBS1in the DNA Damage Response in the Mouse Cerebellum

(2011) Inbal Dar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Release of Mitochondrial Apoptogenic Factors and Cell Death are Mediated by CK2 and NADPH Oxidase

(2011) Gab Seok Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Phosphorylation of Histone H2A.X as an Early Marker of Neuronal Endangerment following Seizures in the Adult Rat Brain

(2011) S. L. Crowe et al.   JOURNAL OF NEUROSCIENCE

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

p53- and Bax-Mediated Apoptosis in Injured Rat Spinal Cord

(2011) Ramaprasada Rao Kotipatruni et al.   NEUROCHEMICAL RESEARCH

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

(2011) R. N. Fernando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors

(2011) Caroline N. Mills et al.   Frontiers in Molecular Neuroscience

DNA damage, neuronal and glial cell death and neurodegeneration

(2010) Ari Barzilai   APOPTOSIS

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

(2010) Jing An et al.   BMC MOLECULAR BIOLOGY

Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice

(2010) B. Nashun et al.   DEVELOPMENT

The MRN complex in double-strand break repair and telomere maintenance

(2010) Brandon J. Lamarche et al.   FEBS LETTERS

Expression of genes coding for histone variants and histone-associated proteins in pluripotent stem cells and mouse preimplantation embryos

(2010) Georgia R. Kafer et al.   GENE EXPRESSION PATTERNS

The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain

(2010) Nnennaya Kanu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Minimally Cytotoxic Doses of Temozolomide Produce Radiosensitization in Human Glioblastoma Cells Regardless of MGMT Expression

(2010) M. S. Bobola et al.   MOLECULAR CANCER THERAPEUTICS

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Dynamic Dependence on ATR and ATM for Double-Strand Break Repair in Human Embryonic Stem Cells and Neural Descendants

(2010) Bret R. Adams et al.   PLoS One

Neuronal Apoptosis in the Developing Cerebellum

(2010) X.-S. Cheng et al.   ANATOMIA HISTOLOGIA EMBRYOLOGIA

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

(2009) Olga A. Sedelnikova et al.   AGING CELL

Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

(2009) Olivier Sordet et al.   EMBO REPORTS

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage

(2009) Celine Ziegler-Birling et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Neural Stem and Progenitor Cells Retain Their Potential for Proliferation and Differentiation into Functional Neurons Despite Lower Number in Aged Brain

(2009) H. Ahlenius et al.   JOURNAL OF NEUROSCIENCE

Characterisation of histone variant distribution in human embryonic stem cells by transfection of in vitro transcribed mRNA

(2009) Margaret L. Shaw et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death

(2009) Bo Tian et al.   NATURE CELL BIOLOGY

A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint

(2009) David Shechter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

Alcohol Induces DNA Damage and the Fanconi Anemia D2 Protein Implicating FANCD2 in the DNA Damage Response Pathways in Brain

(2008) S. L. Rulten et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients

(2008) Alessandra di Masi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma

(2008) X. Mergui et al.   BIOCHIMIE

Inhibition of Glycogen Synthase Kinase 3  Attenuates Neurocognitive Dysfunction Resulting from Cranial Irradiation

(2008) D. K. Thotala et al.   CANCER RESEARCH

The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle

(2008) Sharon Biton et al.   DNA REPAIR

Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells

(2008) J.P. Banáth et al.   EXPERIMENTAL CELL RESEARCH

Histone Modifications and Nuclear Architecture: A Review

(2008) Eva Bártová et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

(2008) S. Solier et al.   MOLECULAR AND CELLULAR BIOLOGY

Early events in the mammalian response to DNA double-strand breaks

(2008) L. C. Riches et al.   MUTAGENESIS

The genetic and molecular basis of Fanconi anemia

(2008) Johan P. de Winter et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Histone H2AX-dependent GABAA receptor regulation of stem cell proliferation

(2008) Michael Andäng et al.   NATURE

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH