Cellular senescence and Alzheimer disease: the egg and the chicken scenario
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Title
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
Authors
Keywords
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Journal
NATURE REVIEWS NEUROSCIENCE
Volume 21, Issue 8, Pages 433-444
Publisher
Springer Science and Business Media LLC
Online
2020-06-29
DOI
10.1038/s41583-020-0325-z
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Note: Only part of the references are listed.- Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
- (2020) Annerieke Sierksma et al. EMBO Molecular Medicine
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence
- (2019) Jie-Yu Liu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin
- (2019) Watson P. Folk et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
- (2019) Rhys Anderson et al. EMBO JOURNAL
- Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
- (2019) Peter J. Thompson et al. Cell Metabolism
- Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
- (2019) Peisu Zhang et al. NATURE NEUROSCIENCE
- Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy
- (2019) Chien-Hsiang Hsu et al. CELL
- Mitochondrial dysfunction and cell senescence: deciphering a complex relationship
- (2019) James Chapman et al. FEBS LETTERS
- The pro-remyelination properties of microglia in the central nervous system
- (2019) Amy F. Lloyd et al. Nature Reviews Neurology
- Ageing as a risk factor for neurodegenerative disease
- (2019) Yujun Hou et al. Nature Reviews Neurology
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
- (2019) LaTonya J. Hickson et al. EBioMedicine
- Targeting normal and cancer senescent cells as a strategy of senotherapy
- (2019) Ewa Sikora et al. AGEING RESEARCH REVIEWS
- Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells
- (2019) Björn Neumann et al. Cell Stem Cell
- Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
- (2019) Markus Riessland et al. Cell Stem Cell
- Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- (2018) Lorenzo Galluzzi et al. CELL DEATH AND DIFFERENTIATION
- Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis
- (2018) Ben Gorissen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
- (2018) Darren J. Baker et al. JOURNAL OF CLINICAL INVESTIGATION
- Strategies targeting cellular senescence
- (2018) Yossi Ovadya et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanisms and functions of cellular senescence
- (2018) Nicolás Herranz et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders
- (2018) Susana Carmona et al. LANCET NEUROLOGY
- Senolytics improve physical function and increase lifespan in old age
- (2018) Ming Xu et al. NATURE MEDICINE
- Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis
- (2018) Claire Vinatier et al. Frontiers in Physiology
- Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?
- (2018) Cyril Laurent et al. Biomedical Journal
- Tau protein aggregation is associated with cellular senescence in the brain
- (2018) Nicolas Musi et al. AGING CELL
- Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
- (2018) Tyler J. Bussian et al. NATURE
- Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
- (2018) Claudio Soto et al. NATURE NEUROSCIENCE
- The dynamic nature of senescence in cancer
- (2018) Soyoung Lee et al. NATURE CELL BIOLOGY
- Impaired immune surveillance accelerates accumulation of senescent cells and aging
- (2018) Yossi Ovadya et al. Nature Communications
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- Senescence and aging: Causes, consequences, and therapeutic avenues
- (2017) Domhnall McHugh et al. JOURNAL OF CELL BIOLOGY
- Fisetin Reduces the Impact of Aging on Behavior and Physiology in the Rapidly Aging SAMP8 Mouse
- (2017) Antonio Currais et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Targeting cellular senescence prevents age-related bone loss in mice
- (2017) Joshua N Farr et al. NATURE MEDICINE
- Regenerating CNS myelin — from mechanisms to experimental medicines
- (2017) Robin J. M. Franklin et al. NATURE REVIEWS NEUROSCIENCE
- Alzheimer's Disease–Related Dementias Summit 2016: National research priorities
- (2017) Roderick A. Corriveau et al. NEUROLOGY
- Cellular senescence drives age-dependent hepatic steatosis
- (2017) Mikolaj Ogrodnik et al. Nature Communications
- Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
- (2017) Lilach Soreq et al. Cell Reports
- Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation
- (2017) Cláudia Caldeira et al. Frontiers in Aging Neuroscience
- Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease
- (2017) Douglas C. Dean et al. JAMA Neurology
- Cellular Senescence: A Translational Perspective
- (2017) James L. Kirkland et al. EBioMedicine
- Antagonistic pleiotropy and mutation accumulation influence human senescence and disease
- (2017) Juan Antonio Rodríguez et al. Nature Ecology & Evolution
- Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses
- (2016) Servet Özcan et al. Aging-US
- Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
- (2016) Christopher D. Wiley et al. Cell Metabolism
- Identification of Senescent Cells in the Bone Microenvironment
- (2016) Joshua N Farr et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Altered Proteins in the Aging Brain
- (2016) Adila Elobeid et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Alzheimer's disease
- (2016) Philip Scheltens et al. LANCET
- Defeating Alzheimer's disease and other dementias: a priority for European science and society
- (2016) Bengt Winblad et al. LANCET NEUROLOGY
- Ageing, neurodegeneration and brain rejuvenation
- (2016) Tony Wyss-Coray NATURE
- Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
- (2016) Darren J. Baker et al. NATURE
- p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
- (2016) Aharon Helman et al. NATURE MEDICINE
- Age-related myelin degradation burdens the clearance function of microglia during aging
- (2016) Shima Safaiyan et al. NATURE NEUROSCIENCE
- Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
- (2016) Reut Yosef et al. Nature Communications
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
- (2015) Yi Zhu et al. AGING CELL
- World Alzheimer report 2014: Dementia and risk reduction
- (2015) Marc Wortmann Alzheimers & Dementia
- Senescent cells communicate via intercellular protein transfer
- (2015) Anat Biran et al. GENES & DEVELOPMENT
- TREM2 sustains microglial expansion during aging and response to demyelination
- (2015) Pietro Luigi Poliani et al. JOURNAL OF CLINICAL INVESTIGATION
- Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells
- (2015) Alessandra Zingoni et al. JOURNAL OF IMMUNOLOGY
- Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
- (2015) Jianhui Chang et al. NATURE MEDICINE
- Cellular senescence in aging and age-related disease: from mechanisms to therapy
- (2015) Bennett G Childs et al. NATURE MEDICINE
- Reactive oxygen species promotes cellular senescence in normal human epidermal keratinocytes through epigenetic regulation of p16INK4a
- (2014) Mina Sasaki et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Are there roles for brain cell senescence in aging and neurodegenerative disorders?
- (2014) Florence C. C. Tan et al. BIOGERONTOLOGY
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
- (2014) Marco Demaria et al. DEVELOPMENTAL CELL
- The role of senescent cells in ageing
- (2014) Jan M. van Deursen NATURE
- The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
- (2014) Alessio Lanna et al. NATURE IMMUNOLOGY
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
- (2013) Mekayla Storer et al. CELL
- Thinking laterally about neurodegenerative proteinopathies
- (2013) Todd E. Golde et al. JOURNAL OF CLINICAL INVESTIGATION
- Genetics of dementia
- (2013) Clement T Loy et al. LANCET
- The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD
- (2013) Sally Hunter et al. MOLECULAR NEUROBIOLOGY
- A complex secretory program orchestrated by the inflammasome controls paracrine senescence
- (2013) Juan Carlos Acosta et al. NATURE CELL BIOLOGY
- Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease
- (2013) Douglas C. Dean et al. JAMA Neurology
- A senescent cell bystander effect: senescence-induced senescence
- (2012) Glyn Nelson et al. AGING CELL
- Ageing as a Risk Factor for Disease
- (2012) Teresa Niccoli et al. CURRENT BIOLOGY
- White matter integrity and vulnerability to Alzheimer's disease: Preliminary findings and future directions
- (2011) Brian T. Gold et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
- (2011) Antero Salminen et al. CELLULAR SIGNALLING
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence
- (2010) Omid Tavana et al. CELL CYCLE
- Oncogene-induced senescence: the bright and dark side of the response
- (2010) Vassilis G Gorgoulis et al. CURRENT OPINION IN CELL BIOLOGY
- The essence of senescence
- (2010) T. Kuilman et al. GENES & DEVELOPMENT
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
- (2009) Wolfgang J. Streit et al. ACTA NEUROPATHOLOGICA
- Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2
- (2009) Paolo Spallarossa et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding
- (2009) Anita Kulukian et al. DEVELOPMENTAL CELL
- Degradation of Amyloid β Protein by Purified Myelin Basic Protein
- (2009) Mei-Chen Liao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy
- (2009) Alix de Calignon et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage
- (2008) Yasuhiro Maejima et al. AGING CELL
- Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
- (2008) ARCHIVES OF NEUROLOGY
- Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
- (2008) Thomas Kuilman et al. CELL
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