The nuclear γ-H2AX apoptotic ring: implications for cancers and autoimmune diseases

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

(2013) Barbara Meyer et al.   NUCLEIC ACIDS RESEARCH

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Lasonolide A, a potent and reversible inducer of chromosome condensation

(2012) Yong-Wei Zhang et al.   CELL CYCLE

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

Preclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancer

(2011) Flavien Devun et al.   JOURNAL OF GASTROENTEROLOGY

MDC1 Cleavage by Caspase-3: A Novel Mechanism for Inactivating the DNA Damage Response during Apoptosis

(2010) S. Solier et al.   CANCER RESEARCH

Monitoring Drug-Induced  H2AX as a Pharmacodynamic Biomarker in Individual Circulating Tumor Cells

(2010) L. H. Wang et al.   CLINICAL CANCER RESEARCH

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

A minority of foci or pan-nuclear apoptotic staining of  H2AX in the S phase after UV damage contain DNA double-strand breaks

(2010) S. de Feraudy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase 0 Clinical Trial of the Poly (ADP-Ribose) Polymerase Inhibitor ABT-888 in Patients With Advanced Malignancies

(2009) Shivaani Kummar et al.   JOURNAL OF CLINICAL ONCOLOGY

Adeno-Associated Virus Replication Induces a DNA Damage Response Coordinated by DNA-Dependent Protein Kinase

(2009) R. A. Schwartz et al.   JOURNAL OF VIROLOGY

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response

(2009) Maria Quanz et al.   PLoS One

Discovery of a new RNA-containing nuclear structure in UVC-induced apoptotic cells by integrated laser electron microscopy

(2008) Matthia A. Karreman et al.   BIOLOGY OF THE CELL

Topoisomerase I Requirement for Death Receptor-induced Apoptotic Nuclear Fission

(2008) Olivier Sordet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Direct Interaction between 53BP1 and MDC1 Is Required for the Recruitment of 53BP1 to Sites of Damage

(2008) Yifat Eliezer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant Adeno-Associated Viral Vectors Are Deficient in Provoking a DNA Damage Response

(2008) M. Fragkos et al.   JOURNAL OF VIROLOGY

Death Receptor-Induced Activation of the Chk2- and Histone H2AX-Associated DNA Damage Response Pathways

(2008) S. Solier et al.   MOLECULAR AND CELLULAR BIOLOGY

Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity

(2008) J. Baure et al.   MUTAGENESIS

The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway

(2008) S Wang   ONCOGENE