The MRN complex in double-strand break repair and telomere maintenance

ATMINistrating ATM signaling

(2011) Nnennaya Kanu et al.   CELL CYCLE

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

(2011) Gerald E. Dodson et al.   CELL CYCLE

Tip60: Connecting chromatin to DNA damage signaling

(2011) Yingli Sun et al.   CELL CYCLE

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

(2010) Jiafeng Gu et al.   DNA REPAIR

ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response

(2010) Eun Ryoung Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints

(2010) Zhongsheng You et al.   TRENDS IN CELL BIOLOGY

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanisms of double-strand break repair in somatic mammalian cells

(2009) Andrea J. Hartlerode et al.   BIOCHEMICAL JOURNAL

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

(2009) R. Scott Williams et al.   CELL

A Supramodular FHA/BRCT-Repeat Architecture Mediates Nbs1 Adaptor Function in Response to DNA Damage

(2009) Janette Lloyd et al.   CELL

At Loose Ends: Resecting a Double-Strand Break

(2009) Kara A. Bernstein et al.   CELL

H2AX: functional roles and potential applications

(2009) Jennifer S. Dickey et al.   CHROMOSOMA

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2

(2009) H Christian Reinhardt et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks

(2009) Yu Zhang et al.   DNA REPAIR

Posttranslational modifications of repair factors and histones in the cellular response to stalled replication forks

(2009) Thomas Schleker et al.   DNA REPAIR

Give me a break: How telomeres suppress the DNA damage response

(2009) Eros Lazzerini Denchi   DNA REPAIR

DNA end resection: Many nucleases make light work

(2009) Eleni P. Mimitou et al.   DNA REPAIR

Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

(2009) Christian T Carson et al.   EMBO JOURNAL

53BP1 promotes ATM activity through direct interactions with the MRN complex

(2009) Ji-Hoon Lee et al.   EMBO JOURNAL

Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system

(2009) Koby Baranes et al.   EXPERIMENTAL NEUROLOGY

From meiosis to postmeiotic events: Alignment and recognition of homologous chromosomes in meiosis

(2009) Da-Qiao Ding et al.   FEBS Journal

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

(2009) E. R.P. Shull et al.   GENES & DEVELOPMENT

The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae

(2009) F. Conde et al.   GENETICS

Exonuclease Function of Human Mre11 Promotes Deletional Nonhomologous End Joining

(2009) Jing Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

(2009) Sairei So et al.   JOURNAL OF CELL BIOLOGY

The Mre11 Complex and the Response to Dysfunctional Telomeres

(2009) C. L. Attwooll et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2

(2009) N. Dimitrova et al.   MOLECULAR AND CELLULAR BIOLOGY

Meiotic DNA Double-Strand Break Repair Requires Two Nucleases, MRN and Ctp1, To Produce a Single Size Class of Rec12 (Spo11)-Oligonucleotide Complexes

(2009) N. Milman et al.   MOLECULAR AND CELLULAR BIOLOGY

CtIP Links DNA Double-Strand Break Sensing to Resection

(2009) Zhongsheng You et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Multiple roles for MRE11 at uncapped telomeres

(2009) Yibin Deng et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

Mre11: roles in DNA repair beyond homologous recombination

(2009) Shan Zha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RAD50 and NBS1 form a stable complex functional in DNA binding and tethering

(2009) Eddy van der Linden et al.   NUCLEIC ACIDS RESEARCH

The Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis

(2009) Elaine M. Taylor et al.   NUCLEIC ACIDS RESEARCH

Ctp1 and Exonuclease 1, alternative nucleases regulated by the MRN complex, are required for efficient meiotic recombination

(2009) J. A. Farah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

The P. furiosus Mre11/Rad50 Complex Promotes 5′ Strand Resection at a DNA Double-Strand Break

(2008) Ben B. Hopkins et al.   CELL

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

The endless tale of non-homologous end-joining

(2008) Eric Weterings et al.   CELL RESEARCH

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae

(2008) Brian M. Wasko et al.   DNA REPAIR

Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

(2008) Ali Jazayeri et al.   EMBO JOURNAL

DNA helicases Sgs1 and BLM promote DNA double-strand break resection

(2008) S. Gravel et al.   GENES & DEVELOPMENT

Recruitment and Dissociation of Nonhomologous End Joining Proteins at a DNA Double-Strand Break in Saccharomyces cerevisiae

(2008) D. Wu et al.   GENETICS

Double functions for the Mre11 complex during DNA double-strand break repair and replication

(2008) Valérie Borde et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Differential Requirements of the C Terminus of Nbs1 in Suppressing Adenovirus DNA Replication and Promoting Concatemer Formation

(2008) S. S. Lakdawala et al.   JOURNAL OF VIROLOGY

Ataxia Telangiectasia-Mutated Damage-Signaling Kinase- and Proteasome-Dependent Destruction of Mre11-Rad50-Nbs1 Subunits in Simian Virus 40-Infected Primate Cells

(2008) X. Zhao et al.   JOURNAL OF VIROLOGY

The importance of making ends meet: Mutations in genes and altered expression of proteins of the MRN complex and cancer

(2008) A DZIKIEWICZKRAWCZYK   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

CDK targets Sae2 to control DNA-end resection and homologous recombination

(2008) Pablo Huertas et al.   NATURE

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

Genome instability: a mechanistic view of its causes and consequences

(2008) Andrés Aguilera et al.   NATURE REVIEWS GENETICS

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Coordinate 5′ and 3′ endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase

(2008) Steven M. Yannone et al.   NUCLEIC ACIDS RESEARCH

Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viral DNA is important for inhibiting DNA replication

(2008) Shomita S. Mathew et al.   VIROLOGY

Characterization of mre11 loss following HSV-1 infection

(2008) Devon A. Gregory et al.   VIROLOGY