A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

Considerations on manganese (Mn) treatments for in vitro studies

(2014) Aaron B. Bowman et al.   NEUROTOXICOLOGY

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

(2013) Dagmar E. Ehrnhoefer et al.   HUMAN MOLECULAR GENETICS

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

(2013) G. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DMH1, a Highly Selective Small Molecule BMP Inhibitor Promotes Neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 Expression during Neural Induction

(2012) M. Diana Neely et al.   ACS Chemical Neuroscience

Alterations in Brain Transition Metals in Huntington Disease

(2012) H. Diana Rosas et al.   ARCHIVES OF NEUROLOGY

Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient

(2012) Jung-Il Chae et al.   BIOCHEMICAL JOURNAL

Human Embryonic Stem Cell-Derived GABA Neurons Correct Locomotion Deficits in Quinolinic Acid-Lesioned Mice

(2012) Lixiang Ma et al.   Cell Stem Cell

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons

(2012) A. D. Carri et al.   DEVELOPMENT

Optimization of Fluorescence Assay of Cellular Manganese Status for High Throughput Screening

(2012) Kevin K. Kumar et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

(2012) Stefano Camnasio et al.   NEUROBIOLOGY OF DISEASE

Manganese induces p21 expression in PC12 cells at the transcriptional level

(2012) F. Zhao et al.   NEUROSCIENCE

Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism

(2012) Jennifer L. Madison et al.   PLoS One

In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Developing Rats, and Impairs Their Motor Function

(2012) Fabiano M. Cordova et al.   PLoS One

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

(2012) Tarja A Juopperi et al.   Molecular Brain

Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

(2011) Fanny Mochel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A bioinformatic assay for pluripotency in human cells

(2011) Franz-Josef Müller et al.   NATURE METHODS

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Induced pluripotent stem cell lines from Huntington's disease mice undergo neuronal differentiation while showing alterations in the lysosomal pathway

(2011) Valentina Castiglioni et al.   NEUROBIOLOGY OF DISEASE

P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease

(2011) Jing Fan et al.   NEUROBIOLOGY OF DISEASE

Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

(2011) Gunnar F. Kwakye et al.   NEUROTOXICOLOGY

Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAA⋅TTC Triplet Repeat Instability

(2010) Sherman Ku et al.   Cell Stem Cell

Pax6 Is a Human Neuroectoderm Cell Fate Determinant

(2010) Xiaoqing Zhang et al.   Cell Stem Cell

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Altered Manganese Homeostasis and Manganese Toxicity in a Huntington's Disease Striatal Cell Model Are Not Explained by Defects in the Iron Transport System

(2010) B. Blairanne Williams et al.   TOXICOLOGICAL SCIENCES

Disease-toxicant screen reveals a neuroprotective interaction between Huntington’s disease and manganese exposure

(2009) B. Blairanne Williams et al.   JOURNAL OF NEUROCHEMISTRY

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Assessing manganese efflux using SEA0400 and cardiacT1-mapping manganese-enhanced MRI in a murine model

(2009) Ben Waghorn et al.   NMR IN BIOMEDICINE

Huntington's disease: the case for genetic modifiers

(2009) James F Gusella et al.   Genome Medicine

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2008) Tomás R. Guilarte et al.   JOURNAL OF NEUROCHEMISTRY

Manganese accumulates primarily in nuclei of cultured brain cells

(2008) Kiran Kalia et al.   NEUROTOXICOLOGY

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats

(2007) M. Morello et al.   NEUROTOXICOLOGY