VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

(2019) Ignacio Campillo-Marcos et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis

(2018) David S. Moura et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of survival motor neuron protein (SMN) in protein homeostasis

(2018) Helena Chaytow et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

(2018) Ignacio Campillo-Marcos et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA plasticity and damage in amyotrophic lateral sclerosis

(2018) Alexandra Kretz et al.   Neural Regeneration Research

Epigenetic Regulation in Neurodegenerative Diseases

(2018) Amit Berson et al.   TRENDS IN NEUROSCIENCES

Impact of DNA repair and stability defects on cortical development

(2018) Federico T. Bianchi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Whole-exome sequencing in fetuses with central nervous system abnormalities

(2018) Adi Reches et al.   Journal of Perinatology

Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

(2018) Aye M. Mon et al.   PLoS One

Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways

(2018) Hadar Vinograd-Byk et al.   Scientific Reports

The impact of histone post-translational modifications in neurodegenerative diseases

(2018) Samantha N. Cobos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog

(2018) Yeen Shian Ngow et al.   PROTEIN SCIENCE

SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities

(2017) Catherine E. Dominguez et al.   HUMAN GENETICS

Xeroderma pigmentosum-Cockayne syndrome complex

(2017) Valerie Natale et al.   Orphanet Journal of Rare Diseases

Prevalence of Pathogenic Copy Number Variation in Adults With Pediatric-Onset Epilepsy and Intellectual Disability

(2017) Felippe Borlot et al.   JAMA Neurology

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage

(2016) Diana M. Monsalve et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity

(2016) Ke-Jun Han et al.   HUMAN MOLECULAR GENETICS

Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1

(2016) Hitoshi Aihara et al.   MOLECULAR CELL

Phosphorylation of Farnesoid X Receptor at Serine 154 Links Ligand Activation With Degradation

(2016) Takuyu Hashiguchi et al.   MOLECULAR ENDOCRINOLOGY

Novel motor phenotypes in patients withVRK1mutations without pontocerebellar hypoplasia

(2016) Marion Stoll et al.   NEUROLOGY

Towards an understanding of regulating Cajal body activity by protein modification

(2016) Michael D. Hebert et al.   RNA Biology

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation

(2016) David S. Moura et al.   Scientific Reports

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage

(2015) Marcella Salzano et al.   Epigenetics

The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-  Precursor Protein-Dependent Mechanism

(2015) H. Vinograd-Byk et al.   JOURNAL OF NEUROSCIENCE

Copy number variations in cryptogenic cerebral palsy

(2015) R. Segel et al.   NEUROLOGY

Cajal Body Proteins Differentially Affect the Processing of Box C/D scaRNPs

(2015) Isioma I. Enwerem et al.   PLoS One

Clinically relevant copy number variations detected in cerebral palsy

(2015) Maryam Oskoui et al.   Nature Communications

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle

(2015) Lara Cantarero et al.   Scientific Reports

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

(2015) Marcella Salzano et al.   Oncotarget

VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage

(2014) Inmaculada López-Sánchez et al.   FEBS LETTERS

Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach

(2014) R. A. Studer et al.   Open Biology

Nucleotide excision repair in chronic neurodegenerative diseases

(2013) Sara Sepe et al.   DNA REPAIR

Rare copy number variation in cerebral palsy

(2013) Gai McMichael et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals

(2013) Iria Barcia-Sanjurjo et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

(2013) Matthew M Dobbin et al.   NATURE NEUROSCIENCE

Mutations inVRK1Associated With Complex Motor and Sensory Axonal Neuropathy Plus Microcephaly

(2013) Claudia Gonzaga-Jauregui et al.   JAMA Neurology

Regulation of the Nijmegen breakage syndrome 1 gene NBS1 by c-myc, p53 and coactivators mediates estrogen protection from DNA damage in breast cancer cells

(2012) ROWENA WAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage

(2012) Marta Sanz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence

(2012) Yoon Ha Choi et al.   NUCLEIC ACIDS RESEARCH

SCA1—Phosphorylation, a regulator of Ataxin-1 function and pathogenesis

(2012) Harry T. Orr   PROGRESS IN NEUROBIOLOGY

Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice

(2012) H Z Yin et al.   Cell Death & Disease

Roles of VRK1 as a new player in the control of biological processes required for cell division

(2011) Alberto Valbuena et al.   CELLULAR SIGNALLING

NMR Solution Structure of Human Vaccinia-related Kinase 1 (VRK1) Reveals the C-terminal Tail Essential for Its Structural Stability and Autocatalytic Activity

(2011) Joon Shin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

(2011) Marta Sanz-García et al.   Journal of Proteomics

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage–induced apoptosis

(2011) Choon-Ho Park et al.   MOLECULAR BIOLOGY OF THE CELL

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

Mutation analysis of VCP in familial and sporadic amyotrophic lateral sclerosis

(2011) Kelly L. Williams et al.   NEUROBIOLOGY OF AGING

VCP mutations in familial and sporadic amyotrophic lateral sclerosis

(2011) Max Koppers et al.   NEUROBIOLOGY OF AGING

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

(2011) Alberto Valbuena et al.   PLoS One

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

(2011) Marta Vázquez-Cedeira et al.   PLoS One

Dominant spinal muscular atrophy with lower extremity predominance: Linkage to 14q32

(2010) M. B. Harms et al.   NEUROLOGY

Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Is Caused by a Mutation in the VRK1 Gene

(2009) Paul Renbaum et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mice Deficient in the Serine/Threonine Protein Kinase VRK1 Are Infertile Due to a Progressive Loss of Spermatogonia1

(2009) Matthew S. Wiebe et al.   BIOLOGY OF REPRODUCTION

Cajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell lines

(2009) S. M. Hearst et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of ATXN1 at Ser776 in the cerebellum

(2009) Nathan D. Jorgensen et al.   JOURNAL OF NEUROCHEMISTRY

Diagnosis and treatment of Friedreich ataxia: a European perspective

(2009) Jörg B. Schulz et al.   Nature Reviews Neurology

Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site

(2009) Eric D. Scheeff et al.   STRUCTURE

VRK1 phosphorylates CREB and mediates CCND1 expression

(2008) T.-H. Kang et al.   JOURNAL OF CELL SCIENCE

Plk3 Interacts with and Specifically Phosphorylates VRK1 in Ser342, a Downstream Target in a Pathway That Induces Golgi Fragmentation

(2008) I. Lopez-Sanchez et al.   MOLECULAR AND CELLULAR BIOLOGY

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

(2008) Alberto Valbuena et al.   PLoS One