m6A modification: recent advances, anticancer targeted drug discovery and beyond
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
m6A modification: recent advances, anticancer targeted drug discovery and beyond
Authors
Keywords
-
Journal
Molecular Cancer
Volume 21, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-14
DOI
10.1186/s12943-022-01510-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells
- (2021) Sarah Huff et al. ACS Chemical Biology
- Artificial Intelligence in Drug Discovery: A Comprehensive Review of Data-driven and Machine Learning Approaches
- (2021) Hyunho Kim et al. BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
- m 6 A RNA methylation: from mechanisms to therapeutic potential
- (2021) P Cody He et al. EMBO JOURNAL
- METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner
- (2021) Xiaoping Pan et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5
- (2021) Dan Zhou et al. Molecular Oncology
- A novel hypoxic long noncoding RNA KB-1980E6.3 maintains breast cancer stem cell stemness via interacting with IGF2BP1 to facilitate c-Myc mRNA stability
- (2021) Pengpeng Zhu et al. ONCOGENE
- ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma
- (2021) Ye Yuan et al. Cell Death & Disease
- EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma
- (2021) Runping Fang et al. Nature Communications
- circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity
- (2021) Botai Li et al. Nature Communications
- Metformin exhibits antiproliferation activity in breast cancer via miR-483-3p/METTL3/m6A/p21 pathway
- (2021) Lin Cheng et al. Oncogenesis
- Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis through m 6 A mRNA Methylation Dependent Mechanism
- (2021) Tianhong Su et al. HEPATOLOGY
- LINC00460/DHX9/IGF2BP2 complex promotes colorectal cancer proliferation and metastasis by mediating HMGA1 mRNA stability depending on m6A modification
- (2021) Pingfu Hou et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- RBM15 facilitates laryngeal squamous cell carcinoma progression by regulating TMBIM6 stability through IGF2BP3 dependent
- (2021) Xin Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells
- (2021) Wenbin Xu et al. Drug Design Development and Therapy
- Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
- (2021) Yi Liu et al. Cell Metabolism
- Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m 6 A‐dependent manner
- (2021) Yushi Chen et al. EMBO REPORTS
- HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA
- (2021) Fengjie Jiang et al. Journal of Hematology & Oncology
- FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2
- (2021) Fei Xu et al. Molecular Cancer
- CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression
- (2021) Fei Xie et al. Molecular Cancer
- Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
- (2021) Eliza Yankova et al. NATURE
- N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway
- (2021) Ping Wu et al. Cell Death & Disease
- Novel Small Molecule RNA m6A Demethylase AlkBH5 Inhibitors for Treating Cancer
- (2021) Ram W. Sabnis ACS Medicinal Chemistry Letters
- Regulatory role and mechanism of m6A RNA modification in human metabolic diseases
- (2021) Yuliang Zhang et al. Molecular Therapy-Oncolytics
- Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors
- (2021) Simona Selberg et al. ACS Omega
- A Light‐Controllable Chemical Modulation of m 6 A RNA Methylation
- (2021) Ling Lan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- N6-methyladenosine-mediated upregulation of WTAPP1 promotes WTAP translation and Wnt signaling to facilitate pancreatic cancer progression
- (2021) Junge Deng et al. CANCER RESEARCH
- YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect
- (2021) Yichao Hou et al. CELL DEATH AND DIFFERENTIATION
- METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes
- (2021) Elena V. Moroz‐Omori et al. ChemMedChem
- The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors
- (2021) Vera Miranda-Gonçalves et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC
- (2021) Xinyi Qian et al. Journal of Hematology & Oncology
- YTHDF2 facilitates UBXN1 mRNA decay by recognizing METTL3-mediated m6A modification to activate NF-κB and promote the malignant progression of glioma
- (2021) Rui-Chao Chai et al. Journal of Hematology & Oncology
- Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
- (2021) Jaclyn M. Einstein et al. MOLECULAR CELL
- A comprehensive review of m6A/m6Am RNA methyltransferase structures
- (2021) Stephanie Oerum et al. NUCLEIC ACIDS RESEARCH
- METTL14 facilitates global genome repair and suppresses skin tumorigenesis
- (2021) Zizhao Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA methyltransferase METTL16 : Targets and function
- (2021) Emily R. Satterwhite et al. Wiley Interdisciplinary Reviews-RNA
- m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
- (2021) Juan Zeng et al. Molecular Therapy-Nucleic Acids
- The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
- (2021) Geni Ye et al. Acta Pharmaceutica Sinica B
- HNRNPA2B1, as a m6A Reader, Promotes Tumorigenesis and Metastasis of Oral Squamous Cell Carcinoma
- (2021) Feiya Zhu et al. Frontiers in Oncology
- Novel evidence for m6A methylation regulators as prognostic biomarkers and FTO as a potential therapeutic target in gastric cancer
- (2021) Tadanobu Shimura et al. BRITISH JOURNAL OF CANCER
- HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells
- (2021) Belinda J. Petri et al. CANCER LETTERS
- FTO promotes multiple myeloma progression by posttranscriptional activation of HSF1 in an m6A-YTHDF2-dependent manner
- (2021) Aoshuang Xu et al. MOLECULAR THERAPY
- Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3β
- (2021) Hongyan Li et al. Clinical and Translational Medicine
- METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing
- (2020) Hao Chen et al. CELL RESEARCH
- KIAA1429 regulates cell proliferation by targeting c‐Jun messenger RNA directly in gastric cancer
- (2020) Ran Miao et al. JOURNAL OF CELLULAR PHYSIOLOGY
- M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma
- (2020) Xueliang Zuo et al. Journal of Hematology & Oncology
- m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling
- (2020) Bo Tang et al. Molecular Cancer
- METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST
- (2020) Xiao Yang et al. Molecular Cancer
- The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation
- (2020) Tao Liu et al. NUCLEIC ACIDS RESEARCH
- RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
- (2020) Chao Shen et al. Cell Stem Cell
- Small‐Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer
- (2020) Rajiv K. Bedi et al. ChemMedChem
- Machine learning models for drug–target interactions: current knowledge and future directions
- (2020) Sofia D’Souza et al. DRUG DISCOVERY TODAY
- SIRT1 regulates N 6 ‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation
- (2020) Xiaoming Liu et al. HEPATOLOGY
- RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF‐ κ B pathway
- (2020) Yi Jiang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- m6A-binding proteins: the emerging crucial performers in epigenetics
- (2020) Yanchun Zhao et al. Journal of Hematology & Oncology
- Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
- (2020) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- m6A-dependent glycolysis enhances colorectal cancer progression
- (2020) Chaoqin Shen et al. Molecular Cancer
- RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
- (2020) Xingya Guo et al. Molecular Cancer
- The potential role of RNA N6-methyladenosine in Cancer progression
- (2020) Tianyi Wang et al. Molecular Cancer
- LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma
- (2020) Yuanyuan Ban et al. Molecular Oncology
- Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis
- (2020) Zhenyao Chen et al. MOLECULAR THERAPY
- An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis
- (2020) Song Zhu et al. Nature Communications
- Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
- (2020) Rui Su et al. CANCER CELL
- FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
- (2020) Hao Huang et al. CANCER RESEARCH
- YTHDF1 promotes gastric carcinogenesis by controlling translation of FZD7
- (2020) Jingnan Pi et al. CANCER RESEARCH
- A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
- (2020) Sara Zaccara et al. CELL
- Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells
- (2020) Terisha Ghazi et al. Epigenetics
- Recent developments of small molecules targeting RNA m6A modulators
- (2020) Jing Gu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
- (2020) Xiaoxiang Chen et al. Molecular Cancer
- m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
- (2020) Jian-Wei Xie et al. Molecular Cancer
- ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
- (2020) Yunhao Chen et al. Molecular Cancer
- METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m6A Methylation in Oral Squamous Cell Carcinoma
- (2020) Lin Liu et al. MOLECULAR THERAPY
- LNC942 promoting METTL14-mediated m6A methylation in breast cancer cell proliferation and progression
- (2020) Tong Sun et al. ONCOGENE
- METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification
- (2020) Wei Zhao et al. Molecular Therapy-Nucleic Acids
- m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis
- (2020) Jun-Ju He et al. Frontiers in Oncology
- Identification of Specific N6-Methyladenosine RNA Demethylase FTO Inhibitors by Single-Quantum-Dot-Based FRET Nanosensors
- (2020) Yan Zhang et al. ANALYTICAL CHEMISTRY
- METTL3-mediated maturation of miR-126-5p promotes ovarian cancer progression via PTEN-mediated PI3K/Akt/mTOR pathway
- (2020) Xuehan Bi et al. CANCER GENE THERAPY
- Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells
- (2020) Fei Peng et al. CELL RESEARCH
- Artificial intelligence in drug discovery and development
- (2020) Debleena Paul et al. DRUG DISCOVERY TODAY
- m 6 A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway
- (2020) Han Zhang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer
- (2020) Zhou Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer
- (2020) Min Wang et al. Molecular Cancer
- Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism
- (2020) Xiaochuan Liu et al. MOLECULAR THERAPY
- The strategies and techniques of drug discovery from natural products
- (2020) Li Zhang et al. PHARMACOLOGY & THERAPEUTICS
- The m6A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor
- (2020) Yiren Xiao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner
- (2020) Shijie Chen et al. Cell Death & Disease
- N6-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer
- (2020) Yiting Sun et al. Cell Death & Disease
- ALKBH5 inhibited cell proliferation and sensitized bladder cancer cells to cisplatin by m6A-CK2α mediated glycolysis
- (2020) Hao Yu et al. Molecular Therapy-Nucleic Acids
- N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1
- (2020) Chenliang Zhou et al. EBioMedicine
- The FTO/miR‐181b‐3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer
- (2020) Yuanyuan Xu et al. Cancer Communications
- YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis
- (2020) Guoqiang Chang et al. CANCER CELL
- DMDRMR-mediated regulation of m6A-modified CDK4 by m6A reader IGF2BP3 drives ccRCC progression
- (2020) Shan Gao et al. CANCER RESEARCH
- Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification
- (2020) Bowen Li et al. DRUG RESISTANCE UPDATES
- Baicalin mediated regulation of key signaling pathways in cancer
- (2020) Shilpi Singh et al. PHARMACOLOGICAL RESEARCH
- The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
- (2020) Lifang Ma et al. Redox Biology
- RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target
- (2020) Huarong Chen et al. GASTROENTEROLOGY
- The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
- (2019) Maosheng Cheng et al. ONCOGENE
- Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
- (2019) Simona Selberg et al. Cell Reports
- Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog
- (2019) Nan Yao et al. Cell Death & Disease
- RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
- (2019) Yi Niu et al. Molecular Cancer
- Health benefits of resveratrol: Evidence from clinical studies
- (2019) Akhand Pratap Singh et al. MEDICINAL RESEARCH REVIEWS
- Rhein from Rheum rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways
- (2019) Shen Zhuang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia
- (2019) Yue Huang et al. CANCER CELL
- Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
- (2019) Jasmin Paris et al. Cell Stem Cell
- Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1
- (2019) Shiming Peng et al. Science Translational Medicine
- Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
- (2019) Liyuan Zhu et al. Cell Death & Disease
- Excessive miR-25-3p maturation via N6-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progression
- (2019) Jialiang Zhang et al. Nature Communications
- YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
- (2019) Yang Bai et al. Frontiers in Oncology
- Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery
- (2019) Xin Yang et al. CHEMICAL REVIEWS
- Identification of Clausine E as an inhibitor of fat mass and obesity‐associated protein (FTO) demethylase activity
- (2019) Ying Wang et al. JOURNAL OF MOLECULAR RECOGNITION
- ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
- (2019) Jun Zhang et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
- (2019) Jie Han et al. Molecular Cancer
- METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
- (2019) Ting Li et al. Molecular Cancer
- The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112
- (2019) Nhan van Tran et al. NUCLEIC ACIDS RESEARCH
- KIAA1429 acts as an oncogenic factor in breast cancer by regulating CDK1 in an N6-methyladenosine-independent manner
- (2019) Jia-Yi Qian et al. ONCOGENE
- m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
- (2019) Seungwon Yang et al. Nature Communications
- FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export
- (2019) Brittany M. Edens et al. Cell Reports
- N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma
- (2019) Fuxi Li et al. CANCER RESEARCH
- Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
- (2019) Wen Peng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- WTAP is a prognostic marker of high-grade serous ovarian cancer and regulates the progression of ovarian cancer cells
- (2019) Hai-Lan Yu et al. OncoTargets and Therapy
- METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
- (2019) Qiang Wang et al. GUT
- METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
- (2019) Ben Yue et al. Molecular Cancer
- Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3
- (2019) Wen Ni et al. Molecular Cancer
- Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
- (2019) Chaohui Gu et al. Molecular Cancer
- YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
- (2019) Jiajie Hou et al. Molecular Cancer
- m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation
- (2019) Ruobing Jia et al. Molecular Cancer
- METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
- (2019) Xiaoxiang Chen et al. MOLECULAR THERAPY
- Chemical inhibitors make their RNA epigenetic mark
- (2019) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway
- (2019) Jiarong Cai et al. OncoTargets and Therapy
- HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine
- (2019) Weili Miao et al. Nature Communications
- YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
- (2019) Yulin Shi et al. Nature Communications
- Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m6A RNA Methylation in the Intestine of Weaning Piglets
- (2019) Zhending Gan et al. ACS Omega
- 3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line
- (2019) Alessio Malacrida et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Machine learning approaches and databases for prediction of drug–target interaction: a survey paper
- (2019) Maryam Bagherian et al. BRIEFINGS IN BIOINFORMATICS
- IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
- (2019) Xiaoge Hu et al. CELL DEATH AND DIFFERENTIATION
- m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis
- (2019) Dan Jin et al. Journal of Hematology & Oncology
- N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1
- (2019) Hongsheng Wang et al. Molecular Cancer
- KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3
- (2019) Tian Lan et al. Molecular Cancer
- m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastoma
- (2019) Li Liu et al. Molecular Cancer
- The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA
- (2019) Rita Pinto et al. NUCLEIC ACIDS RESEARCH
- HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
- (2018) Xiaoli Cai et al. CANCER LETTERS
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m6A-YTHDF2-dependent manner
- (2018) Ruifan Wu et al. INTERNATIONAL JOURNAL OF OBESITY
- Zc3h13 Regulates Nuclear RNA m 6 A Methylation and Mouse Embryonic Stem Cell Self-Renewal
- (2018) Jing Wen et al. MOLECULAR CELL
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- IMPPAT: A curated database of Indian Medicinal Plants, Phytochemistry And Therapeutics
- (2018) Karthikeyan Mohanraj et al. Scientific Reports
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor
- (2018) Katelyn A. Doxtader et al. MOLECULAR CELL
- Identification of Natural Compound Radicicol as a Potent FTO Inhibitor
- (2018) Ruiyong Wang et al. MOLECULAR PHARMACEUTICS
- mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
- (2018) Junho Choe et al. NATURE
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins
- (2018) Xiaojiaoyang Li et al. PHYTOMEDICINE
- A novel m6A reader Prrc2a controls oligodendroglial specification and myelination
- (2018) Rong Wu et al. CELL RESEARCH
- IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
- (2018) Simon Müller et al. NUCLEIC ACIDS RESEARCH
- m6A-mediated ZNF750 repression facilitates nasopharyngeal carcinoma progression
- (2018) Panpan Zhang et al. Cell Death & Disease
- YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
- (2018) Li Zhong et al. CANCER LETTERS
- MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein
- (2017) Zhe Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Study of the Binding between Camptothecin Analogs and FTO by Spectroscopy and Molecular Docking
- (2017) Ting Ren et al. JOURNAL OF FLUORESCENCE
- Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia
- (2017) Jianbiao Zhou et al. Journal of Hematology & Oncology
- Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling
- (2017) Lijiao Zhang et al. JOURNAL OF MOLECULAR RECOGNITION
- Single-step production of the simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus
- (2017) Xuenian Huang et al. METABOLIC ENGINEERING
- Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
- (2017) Isaia Barbieri et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- Dynamic m6A modification regulates local translation of mRNA in axons
- (2017) Jun Yu et al. NUCLEIC ACIDS RESEARCH
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- Baicalin hydrate inhibits cancer progression in nasopharyngeal carcinoma by affecting genome instability and splicing
- (2017) Weiwei Lai et al. Oncotarget
- Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- (2017) Anna Lewinska et al. Theranostics
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
- (2017) Yuko Ueda et al. Scientific Reports
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
- (2016) Wen Xiao et al. MOLECULAR CELL
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
- (2015) Claudio R. Alarcón et al. CELL
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
- (2015) Tianlu Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
- (2015) Nian Liu et al. NATURE
- A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO
- (2015) Joel D. W. Toh et al. Chemical Science
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
- (2014) Yue Huang et al. NUCLEIC ACIDS RESEARCH
- TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
- (2014) Jinlong Ru et al. Journal of Cheminformatics
- Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
- (2013) WeiShen Aik et al. JOURNAL OF MEDICINAL CHEMISTRY
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor
- (2012) Baoen Chen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search