Identification of Clausine E as an inhibitor of fat mass and obesity‐associated protein (FTO) demethylase activity

FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling

(2018) Huajie Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dibenzofuran, dibenzothiophene and N -methyl carbazole tethered 2-aminothiazoles and their cinnamamides as potent inhibitors of Mycobacterium tuberculosis

(2018) Goverdhan Surineni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

Role of N 6 -methyladenosine modification in cancer

(2018) Xiaolan Deng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

FTO, m6 Am , and the hypothesis of reversible epitranscriptomic mRNA modifications

(2018) Jan Mauer et al.   FEBS LETTERS

Identification of the binding between three fluoronucleoside analogues and fat mass and obesity-associated protein by isothermal titration calorimetry and spectroscopic techniques

(2018) Zhigang Li et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of Natural Compound Radicicol as a Potent FTO Inhibitor

(2018) Ruiyong Wang et al.   MOLECULAR PHARMACEUTICS

Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase activity

(2018) Xinxin Han et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interaction of two flavonols with fat mass and obesity-associated protein investigated by fluorescence quenching and molecular docking

(2017) Zechun Wang et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Study of the Binding between Camptothecin Analogs and FTO by Spectroscopy and Molecular Docking

(2017) Ting Ren et al.   JOURNAL OF FLUORESCENCE

Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling

(2017) Lijiao Zhang et al.   JOURNAL OF MOLECULAR RECOGNITION

Binding of clenbuterol to HSA and FTO: a spectroscopic analysis and molecular docking

(2017) Zechun Wang et al.   MEDICINAL CHEMISTRY RESEARCH

Investigation of the interaction between FTO and 3-substituted 2-aminochromones by spectroscopy and molecular modeling

(2017) Lijiao Zhang et al.   MEDICINAL CHEMISTRY RESEARCH

A Novel Inhibitor of the Obesity-Related Protein FTO

(2016) Yan Qiao et al.   BIOCHEMISTRY

Investigation of the Interaction between 1,3-Diazaheterocyclic Compounds and the Fat Mass and Obesity-Associated Protein by Fluorescence Spectroscopy and Molecular Modeling

(2016) Lijiao Zhang et al.   JOURNAL OF FLUORESCENCE

Divergent Syntheses of Carbazole Alkaloids Clausenapin, Indizoline, Claulansine M, and Clausenaline D

(2016) Yizhen Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Total synthesis of diverse oxygenated carbazoles by modified aromatization using molecular iodine

(2016) Vivek T. Humne et al.   TETRAHEDRON LETTERS

Clauemarazoles A–G, seven carbazole alkaloids from the stems of Clausena emarginata

(2015) Hong-Min Xia et al.   FITOTERAPIA

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

(2015) Wu He et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

(2015) Tianlu Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total synthesis of clausamine E and furanoclausamine B

(2015) Dipakranjan Mal et al.   TETRAHEDRON

Synthesis of a FTO Inhibitor with Anticonvulsant Activity

(2014) Guanqun Zheng et al.   ACS Chemical Neuroscience

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Constituents of the Roots of Clausena lansium and Their Potential Anti-inflammatory Activity

(2014) De-Yang Shen et al.   JOURNAL OF NATURAL PRODUCTS

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Two new cytotoxic constituents from the Clausena lansium (Lour.) Skeels

(2014) Hai-Yan Jiang et al.   Phytochemistry Letters

Carbazole alkaloids and coumarins from the roots of Clausena guillauminii

(2014) Chiramet Auranwiwat et al.   Phytochemistry Letters

The bigger picture of FTO—the first GWAS-identified obesity gene

(2013) Ruth J. F. Loos et al.   Nature Reviews Endocrinology

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCδ phosphorylation

(2011) Wei Lin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Constituents from Clausena excavata

(2008) Zhen-Qiang Xin et al.   CHEMICAL & PHARMACEUTICAL BULLETIN