RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation

(2018) Yuan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

The MiR-135b–BMAL1–YY1 loop disturbs pancreatic clockwork to promote tumourigenesis and chemoresistance

(2018) Weiliang Jiang et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

(2017) Chau-To Kwok et al.   Journal of Hematology & Oncology

m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

(2017) Hua-Bing Li et al.   NATURE

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

FTO expression is associated with the occurrence of gastric cancer and prognosis

(2017) Dong Xu et al.   ONCOLOGY REPORTS

Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer

(2017) Xiuli Wang et al.   Oncotarget

Cancer treatment and survivorship statistics, 2016

(2016) Kimberly D. Miller et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway

(2016) Weiliang Jiang et al.   CANCER LETTERS

RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

(2016) Atsushi Tanabe et al.   CANCER LETTERS

Posttranscriptional m 6 A Editing of HIV-1 mRNAs Enhances Viral Gene Expression

(2016) Edward M. Kennedy et al.   Cell Host & Microbe

Pancreatic cancer

(2016) Terumi Kamisawa et al.   LANCET

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis

(2015) C. Xing et al.   CANCER RESEARCH

5′ UTR m6A Promotes Cap-Independent Translation

(2015) Kate D. Meyer et al.   CELL

Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

(2015) Liwen Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages

(2015) Alessandra Rosati et al.   Nature Communications

The circadian timing system in clinical oncology

(2014) Pasquale F. Innominato et al.   ANNALS OF MEDICINE

Loss of circadian clock gene expression is associated with tumor progression in breast cancer

(2014) Cristina Cadenas et al.   CELL CYCLE

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

(2014) Schraga Schwartz et al.   Cell Reports

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Aberrant Expression of Clock Gene Period1 and Its Correlations with the Growth, Proliferation and Metastasis of Buccal Squamous Cell Carcinoma

(2013) Ningbo Zhao et al.   PLoS One

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

New strategies and designs in pancreatic cancer research: consensus guidelines report from a European expert panel

(2011) J.- L. Van Laethem et al.   ANNALS OF ONCOLOGY

CNT1 Expression Influences Proliferation and Chemosensitivity in Drug-Resistant Pancreatic Cancer Cells

(2011) Y. D. Bhutia et al.   CANCER RESEARCH

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

A Role for the Clock Gene Per1 in Prostate Cancer

(2009) Q. Cao et al.   CANCER RESEARCH

Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer

(2009) Nazanin Mostafaie et al.   MOLECULAR CARCINOGENESIS