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Common and distinct regulation of human and mouse brown and beige adipose tissues: a promising therapeutic target for obesity

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Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice

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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells

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N6-methyladenosine Modulates Messenger RNA Translation Efficiency

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m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency

(2015) Tong Chen et al.   Cell Stem Cell

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

(2015) Wu He et al.   JOURNAL OF MEDICINAL CHEMISTRY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO

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Synthesis of a FTO Inhibitor with Anticonvulsant Activity

(2014) Guanqun Zheng et al.   ACS Chemical Neuroscience

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FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver

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FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

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Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

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Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)

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(2013) Xiao Wang et al.   NATURE

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(2013) Matthew Harms et al.   NATURE MEDICINE

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(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

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Role for the obesity-related FTO gene in the cellular sensing of amino acids

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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

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Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

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Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening

(2012) Ran Cao et al.   Journal of Chemical Information and Modeling

ZINC: A Free Tool to Discover Chemistry for Biology

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Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

(2012) Xingyu Lin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

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FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

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(2012) Dan Dominissini et al.   NATURE

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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

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(2010) Michael M. Mysinger et al.   Journal of Chemical Information and Modeling

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

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Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

(2010) T. Nagashima et al.   MOLECULAR PHARMACOLOGY

FTO effect on energy demand versus food intake

(2010) John R. Speakman   NATURE

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

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(2009) Likun Wang et al.   BIOINFORMATICS

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(2009) Cole Trapnell et al.   BIOINFORMATICS

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men

(2008) Kristina Annerbrink et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase

(2008) D. Babovic et al.   NEUROSCIENCE

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(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

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(2008) Yong Zhang et al.   GENOME BIOLOGY