Article
Genetics & Heredity
Huijie Wu, Jingyuan Zhou, Songda Chen, Lingyu Zhu, Mengjie Jiang, Aiqun Liu
Summary: This study identified a potential prognostic signature consisting of seven lncRNAs, with LINC01614 found to be an oncogenic lncRNA in gastric cancer (GC). The results revealed that LINC01614 promotes cell proliferation, migration, invasion, and epithelial-mesenchymal transition in GC cells.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Kai Guo, Di Qi, Bo Huang
Summary: The study revealed that lncRNA MEG8 plays a critical role in the development of NSCLC by modulating the miR-15a/b-5p/PSAT1 axis, indicating that lncRNA MEG8, miR-15a-5p, miR-15b-5p, and PSAT1 may serve as potential targets for NSCLC therapy.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Xiaojing Liu, Na Niu, Pibao Li, Liping Zhai, Ke Xiao, Wendan Chen, Xuewei Zhuang
Summary: The study found that the expression of OGFRP1 was higher in NSCLC tissues than in normal lung tissue; siOGFRP1 inhibited the proliferation, migration, and invasion of A549 and H1299 cells to inhibit the progression of NSCLC, and OGFRP1 could directly interact with miR-4640-5p to regulate the development of NSCLC through the miR-4640-5p/eIF5A axis.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjold, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Summary: The authors developed a method to simultaneously measure protein expression and thermal stability changes during cell type transitions, and applied this approach to study differences between human pluripotent stem cells and other cell types. They detected alterations of protein properties in numerous cellular pathways and components, proposing a method for maintaining pluripotency.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Qian Hua, Dongliang Wang, Lin Zhao, Zhihui Hong, Kairu Ni, Yizhen Shi, Zengli Liu, Baoming Mi
Summary: AL355338 is an upregulated glycolysis-associated lncRNA in NSCLC, promoting aerobic glycolysis and disease progression through direct binding with ENO1, enhancing protein stability, and modulating downstream signaling pathways like EGFR-AKT. Targeting AL355338 could be an effective therapeutic strategy for NSCLC.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yantao Liu, Yuping Yang, Lingli Zhang, Jiaqiang Lin, Bin Li, Min Yang, Honghui Li, Kangwu Chen, Wei Zhao
Summary: The study revealed that ASAP1-IT1 promotes NSCLC progression by regulating cancer cell stemness, interacts with miR-509-3p, and influences the level of YAP1. Targeting this ASAP1-IT1/miR-509-3p signaling axis may be a promising therapeutic strategy to overcome NSCLC stemness.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Xiufeng Hu, Yu Mu, Jiaojie Wang, Yanqiu Zhao
Summary: This study demonstrates that TDRG1 is significantly overexpressed in NSCLC, and interacts with miR-873-5p to positively regulate the expression of ZEB1, thereby facilitating the progression of NSCLC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Oncology
Masafumi Horie, Hidenori Tanaka, Masami Suzuki, Yoshihiko Sato, So Takata, Erina Takai, Naoya Miyashita, Akira Saito, Yoichiro Nakatani, Shinichi Yachida
Summary: This study explored the epigenomic landscape of GIS-NEC and SCLC and identified ELF3 as a super-enhancer-related transcription factor in NEC. ELF3 regulates multiple genes and its depletion leads to poor cell viability. Moreover, GIS-NEC patients can be divided into two subgroups based on the ELF3 signature, with tumor-promoting pathways being activated in the ELF3 signature-high group.
Article
Orthopedics
Feiri Huang, Zhongliang Su, Jie Yang, Xizhen Zhao, Yaozeng Xu
Summary: This study identified a novel regulatory mechanism of long noncoding RNA (lncRNA) NEAT1 in the pathogenesis of osteoarthritis (OA). The downregulation of NEAT1 led to the upregulation of miR-374b-5p and PGAP1, resulting in the secretion of inflammatory cytokines and apoptosis of chondrocytes, which play important roles in the development of OA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Oncology
Tingting Shi, Weijuan Sun, Yan-Long Shi, Qiang Wang, Ze-Xuan Yan, Mei Zhang
Summary: OSER1-AS1 promotes gefitinib resistance in lung adenocarcinoma by regulating the miR-612/FOXM1 axis, and high OSER1-AS1 expression predicts disease progression.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yanhua Zhang, Meng Zheng, Lingyan Zhang, Ping Yuan, Jianbo Zhou, Yongfang Wang, Haihong Wang
Summary: This study found that LOXL1-AS1 is upregulated in cervical cancer and its depletion can inhibit the malignant behaviors of cervical cancer cells, including proliferation, migration, invasion, and angiogenesis. LOXL1-AS1 upregulates Lysophospholipase 1 expression and functions as a sponge for miR-526b-5p.
BIOCHEMICAL GENETICS
(2022)
Article
Environmental Sciences
Bugao Guan, Jun Ma, Zhi Yang, Fei Yu, Jian Yao
Summary: The lncRNA NCK1-AS1 is highly expressed in gastric cancer and acts as an oncogene by competitively binding to miR-22-3p to upregulate BCL9 expression, leading to the activation of the Wnt/β-catenin signaling pathway and promoting gastric cancer progression.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell & Tissue Engineering
Shi-Yuan Liu, Zhi-Yu Zhao, Zhe Qiao, Shao-Min Li, Wei-Ning Zhang
Summary: Long noncoding RNA PCAT1 interacts with DKC1 to regulate proliferation, invasion, and apoptosis in NSCLC cells through the VEGF/AKT/Bcl-2/caspase9 pathway. PCAT1 not only promotes NSCLC cell proliferation and invasion but also inhibits cell apoptosis, and its effects with DKC1 on NSCLC functions are synergistic. Inhibition of epidermal growth factor receptor, AKT, or Bcl-2 could eliminate the effect of PCAT1/DKC1 co-overexpression on NSCLC cell behaviors.
CELL TRANSPLANTATION
(2021)
Article
Oncology
Guodong Xiao, Feng Cheng, Jing Yuan, Weiping Lu, Peili Wang, Huijie Fan
Summary: This study identified a nine-gene signature as an efficient prognostic indicator for breast cancer patients. Among these genes, EZR, as an oncogene, was found to be highly expressed in breast cancer cells and tissue, and involved in regulating breast cancer metastasis.
Article
Oncology
Xueshan Zhao, Xiaodong Jin, Qiuning Zhang, Ruifeng Liu, Hongtao Luo, Zhen Yang, Yichao Geng, Shuangwu Feng, Chengcheng Li, Lina Wang, Xiaohu Wang, Qiang Li
Summary: The lncRNA H19 plays a role in regulating radiosensitivity in NSCLC cells and may serve as a potential therapeutic target and impact the effectiveness of anti-tumor radiotherapy in NSCLC.
CANCER CELL INTERNATIONAL
(2021)