Inflammatory Bowel Disease Therapeutics: A Focus on Probiotic Engineering

Gut microbiota and inflammatory bowel disease: The current status and perspectives

(2021) Lie Zheng et al.   World Journal of Clinical Cases

Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota–Immune System Interplay. Implications for Health and Disease

(2021) Cielo García-Montero et al.   Nutrients

Microbiome and Its Role in Irritable Bowel Syndrome

(2020) Mark Pimentel et al.   DIGESTIVE DISEASES AND SCIENCES

The microbiome and inflammatory bowel disease

(2020) Kerri L. Glassner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pathway paradigms revealed from the genetics of inflammatory bowel disease

(2020) Daniel B. Graham et al.   NATURE

The Evolving Role of Gut Microbiota in the Management of Irritable Bowel Syndrome: An Overview of the Current Knowledge

(2020) Amir Mari et al.   Journal of Clinical Medicine

Head-to-head trials in inflammatory bowel disease: past, present and future

(2020) Lieven Pouillon et al.   Nature Reviews Gastroenterology & Hepatology

What’s new in IBD therapy: an “omics network” approach

(2020) Claudio Fiocchi et al.   PHARMACOLOGICAL RESEARCH

Nutrition, IBD and Gut Microbiota: A Review

(2020) Maria Chiara Mentella et al.   Nutrients

Engineered Probiotics for Detection and Treatment of Inflammatory Intestinal Diseases

(2020) Maria Barra et al.   Frontiers in Bioengineering and Biotechnology

A unified catalog of 204,938 reference genomes from the human gut microbiome

(2020) Alexandre Almeida et al.   NATURE BIOTECHNOLOGY

The Effectiveness of Probiotics in the Treatment of Inflammatory Bowel Disease (IBD)—A Critical Review

(2020) Dominika Jakubczyk et al.   Nutrients

Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity

(2020) Xin Fang et al.   INFLAMMATORY BOWEL DISEASES

Understanding the impact of antibiotic perturbation on the human microbiome

(2020) D. J. Schwartz et al.   Genome Medicine

Key Strategies to Optimize Outcomes in Mild-to-Moderate Ulcerative Colitis

(2020) Virginia Solitano et al.   Journal of Clinical Medicine

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt+ Regulatory T Cells and Exacerbate Colitis in Mice

(2019) Graham J. Britton et al.   IMMUNITY

Targeting ideal oral vaccine vectors based on probiotics: a systematical view

(2019) Boyu Jiang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD

(2019) Anaïs Larabi et al.   Autophagy

Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships

(2019) Damian R. Plichta et al.   CELL

Inflammatory cytokines: from discoveries to therapies in IBD

(2019) Irene Marafini et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Anti-TNF therapy in IBD exerts its therapeutic effect through macrophage IL-10 signalling

(2019) Pim J Koelink et al.   GUT

IL-10 signaling in dendritic cells controls IL-1β-mediated IFNγ secretion by human CD4+ T cells: relevance to inflammatory bowel disease

(2019) S. Veenbergen et al.   Mucosal Immunology

Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome

(2019) Israr Khan et al.   Pathogens

Engineered E. coli Nissle 1917 for the delivery of matrix-tethered therapeutic domains to the gut

(2019) Pichet Praveschotinunt et al.   Nature Communications

Systematic review with meta-analysis: association between acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) and risk of Crohn's disease and ulcerative colitis exacerbation

(2018) O. O. Moninuola et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota

(2018) Cynthia Reinoso Webb et al.   INFLAMMATORY BOWEL DISEASES

Probiotic Species in the Modulation of Gut Microbiota: An Overview

(2018) Md. Abul Kalam Azad et al.   Biomed Research International

Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance

(2018) Whitney Duff et al.   WORLD JOURNAL OF GASTROENTEROLOGY

OUP accepted manuscript

(2018)   Advances in Nutrition

American Gastroenterological Association Institute Guideline on the Management of Mild-to-Moderate Ulcerative Colitis

(2018) Cynthia W. Ko et al.   GASTROENTEROLOGY

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

(2018) Alexander R. Moschen et al.   Nature Reviews Gastroenterology & Hepatology

Harnessing CRISPR-Cas systems for precision engineering of designer probiotic lactobacilli

(2018) Yong Jun Goh et al.   CURRENT OPINION IN BIOTECHNOLOGY

Probiotics in Inflammatory Bowel Disease

(2017) Bincy P. Abraham et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10–Dependent, T-Cell–Independent Attenuation of Colonic Mucosal Innate Immune Responses

(2017) Mairi H. McLean et al.   INFLAMMATORY BOWEL DISEASES

Faecalibacterium prausnitzii: from microbiology to diagnostics and prognostics

(2017) Mireia Lopez-Siles et al.   ISME Journal

Gut microbiota and IBD: causation or correlation?

(2017) Josephine Ni et al.   Nature Reviews Gastroenterology & Hepatology

Targeting IL-10 Family Cytokines for the Treatment of Human Diseases

(2017) Xiaoting Wang et al.   Cold Spring Harbor Perspectives in Biology

Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens

(2017) Moloko Gloria Mathipa et al.   Gut Pathogens

IBD and Environment: Are There Differences between East and West

(2016) Richard B. Gearry   DIGESTIVE DISEASES

Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease

(2016) Caroline Andrews et al.   INFLAMMATORY BOWEL DISEASES

Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes

(2016) Siddharth Singh et al.   Nature Reviews Gastroenterology & Hepatology

Genome Analysis and Characterisation of the Exopolysaccharide Produced by Bifidobacterium longum subsp. longum 35624™

(2016) Friedrich Altmann et al.   PLoS One

The paradoxical role of IL-10 in immunity and cancer

(2015) Mark H. Mannino et al.   CANCER LETTERS

Risk and Safety of Probiotics

(2015) Shira Doron et al.   CLINICAL INFECTIOUS DISEASES

The gut microbiome in health and in disease

(2015) Andrew B. Shreiner et al.   CURRENT OPINION IN GASTROENTEROLOGY

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

The epidemiology of inflammatory bowel disease

(2015) Johan Burisch et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Role of the normal gut microbiota

(2015) Sai Manasa Jandhyala   WORLD JOURNAL OF GASTROENTEROLOGY

Inflammatory Bowel Disease in Children and Adolescents

(2015) Michael J. Rosen et al.   JAMA Pediatrics

The Diagnostic Approach to Monogenic Very Early Onset Inflammatory Bowel Disease

(2014) Holm H. Uhlig et al.   GASTROENTEROLOGY

Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies

(2014) Fergus Shanahan et al.   GASTROENTEROLOGY

Ciprofloxacin and probiotic Escherichia coli Nissle add-on treatment in active ulcerative colitis: A double-blind randomized placebo controlled clinical trial

(2014) Andreas Munk Petersen et al.   Journal of Crohns & Colitis

Surface area of the digestive tract – revisited

(2014) Herbert F Helander et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Association betweenFaecalibacterium prausnitziiReduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature

(2014) Yuan Cao et al.   Gastroenterology Research and Practice

Oral Delivery of IL-27 Recombinant Bacteria Attenuates Immune Colitis in Mice

(2013) Miranda L. Hanson et al.   GASTROENTEROLOGY

Vaccination strategies in patients with IBD

(2013) Javier P. Gisbert et al.   Nature Reviews Gastroenterology & Hepatology

DNA methylation in inflammatory bowel disease and beyond

(2013) Daren Low   WORLD JOURNAL OF GASTROENTEROLOGY

Probiotic Mechanisms of Action

(2012) Miriam Bermudez-Brito et al.   ANNALS OF NUTRITION AND METABOLISM

The Microbiome in Infectious Disease and Inflammation

(2012) Kenya Honda et al.   Annual Review of Immunology

Probiotics—Interactions with Bile Acids and Impact on Cholesterol Metabolism

(2012) Nebojša Pavlović et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The Impact of the Gut Microbiota on Human Health: An Integrative View

(2012) Jose C. Clemente et al.   CELL

The Genetics Universe of Crohn’s Disease and Ulcerative Colitis

(2012) Miles Parkes   DIGESTIVE DISEASES

Evaluation of the Anti-Inflammatory Effect of Milk Fermented by a Strain of IL-10-Producing Lactococcus lactis Using a Murine Model of Crohn’s Disease

(2012) Silvina del Carmen et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Programming of Host Metabolism by the Gut Microbiota

(2011) Fredrik Bäckhed   ANNALS OF NUTRITION AND METABOLISM

Bifidobacterium infantis35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells

(2011) Patrycja Konieczna et al.   GUT

INSPIRE study: Does stress management improve the course of inflammatory bowel disease and disease-specific quality of life in distressed patients with ulcerative colitis or crohnʼs disease? A randomized controlled trial

(2011) Birgitte Boye et al.   INFLAMMATORY BOWEL DISEASES

Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: Bacteriocins and conjugated linoleic acid

(2011) Eileen F. O'Shea et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

The Effect of a Multispecies Probiotic Mixture on the Symptoms and Fecal Microbiota in Diarrhea-dominant Irritable Bowel Syndrome

(2011) Bong Ki Cha et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Immunomodulatory mechanisms of lactobacilli

(2011) Jerry M Wells   Microbial Cell Factories

Treatment of Relapsing Mild-to-Moderate Ulcerative Colitis With the Probiotic VSL#3 as Adjunctive to a Standard Pharmaceutical Treatment: A Double-Blind, Randomized, Placebo-Controlled Study

(2010) Antonio Tursi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

(2010) Jurgen Karczewski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hypocholesterolaemic effect of dietary inclusion of two putative probiotic bile salt hydrolase-producing Lactobacillus plantarum strains in Sprague–Dawley rats

(2010) Rajesh Kumar et al.   BRITISH JOURNAL OF NUTRITION

Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease

(2010) Mark J. Asquith et al.   GASTROENTEROLOGY

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Toll-like receptors in the development of immunotolerance mediated by probiotics

(2010) Carolina Gómez-Llorente et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Leukocytapheresis in the treatment of inflammatory bowel disease: Current position and perspectives

(2010) Piero Vernia et al.   TRANSFUSION AND APHERESIS SCIENCE

Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era

(2009) Geoffrey A. Preidis et al.   GASTROENTEROLOGY

Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus

(2009) Z. Z R Hamady et al.   GUT

Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced byLactobacillus caseithrough Toll-like receptor 2-dependent and independent mechanisms

(2009) Kan Shida et al.   IMMUNOLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Human-derived probiotic Lactobacillus reuteri demonstrate antimicrobial activities targeting diverse enteric bacterial pathogens

(2008) Jennifer K. Spinler et al.   ANAEROBE

The Safety of Probiotics

(2008) David R. Snydman   CLINICAL INFECTIOUS DISEASES

Microbial Influences in Inflammatory Bowel Diseases

(2008) R. Balfour Sartor   GASTROENTEROLOGY

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Crohnʼs disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora

(2007) Alexander Swidsinski et al.   INFLAMMATORY BOWEL DISEASES