Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease

Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis

(2017) Xiu-Peng Xu et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Immunobiology of Interleukin-27

(2015) Hiroki Yoshida et al.   Annual Review of Immunology

IL-27-induced modulation of autoimmunity and its therapeutic potential

(2015) Rakeshchandra R. Meka et al.   AUTOIMMUNITY REVIEWS

The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity

(2015) Samadhi Aparicio-Siegmund et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The presence of interleukin-27 during monocyte-derived dendritic cell differentiation promotes improved antigen processing and stimulation of T cells

(2015) Joo-Yong Jung et al.   IMMUNOLOGY

An IL-27/Lag3 axis enhances Foxp3+ regulatory T cell–suppressive function and therapeutic efficacy

(2015) J-s Do et al.   Mucosal Immunology

IL-27 rs153109 polymorphism increases the risk of colorectal cancer in Chinese Han population

(2015) Shi-xu Lyu et al.   OncoTargets and Therapy

An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction

(2015) Chen Zhu et al.   Nature Communications

Association of 3 Common Polymorphisms of IL-27 Gene with Susceptibility to Cancer in Chinese: Evidence From an Updated Meta-Analysis of 27 Studies

(2015) Meng Zhang et al.   MEDICAL SCIENCE MONITOR

A Phase 2 Study of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients With Crohn’s Disease

(2014) William J. Sandborn et al.   Clinical Gastroenterology and Hepatology

Attenuation of Intestinal Inflammation in Interleukin-10-Deficient Mice Infected with Citrobacter rodentium

(2014) Sara M. Dann et al.   INFECTION AND IMMUNITY

A Soluble Form of IL-27R  Is a Natural IL-27 Antagonist

(2014) C. Dietrich et al.   JOURNAL OF IMMUNOLOGY

Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza

(2014) Francesca Diane M. Liu et al.   PLoS Pathogens

Oral Delivery of IL-27 Recombinant Bacteria Attenuates Immune Colitis in Mice

(2013) Miranda L. Hanson et al.   GASTROENTEROLOGY

Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis

(2013) Leon P McLean et al.   Immunotherapy

TH17 Cell Induction and Effects of IL-17A and IL-17F Blockade in Experimental Colitis

(2013) Esben Gjerløff Wedebye Schmidt et al.   INFLAMMATORY BOWEL DISEASES

A Novel Role for IL-27 in Mediating the Survival of Activated Mouse CD4 T Lymphocytes

(2013) G. Kim et al.   JOURNAL OF IMMUNOLOGY

IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice

(2013) A Visperas et al.   Mucosal Immunology

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39

(2013) Ivan D Mascanfroni et al.   NATURE IMMUNOLOGY

Neutrophils Are Essential As A Source Of Il-17 In The Effector Phase Of Arthritis

(2013) Masaki Katayama et al.   PLoS One

Mo2083 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease

(2012) Stephan R. Targan et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

Interleukin-27 Priming of T Cells Controls IL-17 Production In trans via Induction of the Ligand PD-L1

(2012) Kiyoshi Hirahara et al.   IMMUNITY

Efficacy, safety and tolerability of vidofludimus in patients with inflammatory bowel disease: The ENTRANCE study

(2012) K.R. Herrlinger et al.   Journal of Crohns & Colitis

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon

(2012) Seong Gyu Jeon et al.   PLoS Pathogens

Review article: remission rates achievable by current therapies for inflammatory bowel disease

(2011) L. Peyrin-Biroulet et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity

(2011) Que T. Lambert et al.   BIOCHEMICAL JOURNAL

Association of single nucleotide polymorphisms in IL-12 and IL-27 genes with colorectal cancer risk

(2011) Zhao-Quan Huang et al.   CLINICAL BIOCHEMISTRY

Interleukin-35 Mediates Mucosal Immune Responses That Protect Against T-Cell–Dependent Colitis

(2011) Stefan Wirtz et al.   GASTROENTEROLOGY

New therapies for inflammatory bowel disease: from the bench to the bedside

(2011) Silvio Danese   GUT

The WSX-1 pathway restrains intestinal T-cell immunity

(2011) J. P. McAleer et al.   INTERNATIONAL IMMUNOLOGY

A Novel Role for Interleukin-27 (IL-27) as Mediator of Intestinal Epithelial Barrier Protection Mediated via Differential Signal Transducer and Activator of Transcription (STAT) Protein Signaling and Induction of Antibacterial and Anti-inflammatory Proteins

(2011) Julia Diegelmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for IL-27 in Limiting T Regulatory Cell Populations

(2011) E. D. Tait Wojno et al.   JOURNAL OF IMMUNOLOGY

Mast Cells and Neutrophils Release IL-17 through Extracellular Trap Formation in Psoriasis

(2011) A. M. Lin et al.   JOURNAL OF IMMUNOLOGY

Th17 Cell Accumulation Is Decreased during Chronic Experimental Colitis by (n-3) PUFA in Fat-1 Mice

(2011) Jennifer M. Monk et al.   JOURNAL OF NUTRITION

IL-17: intestinal effector or protector?

(2011)   Mucosal Immunology

Treatment with IL-27 attenuates experimental colitis through the suppression of the development of IL-17-producing T helper cells

(2010) Tetsumasa Sasaoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3

(2010) Hui Wang et al.   IMMUNOLOGY LETTERS

IL-27 promotes T cell–dependent colitis through multiple mechanisms

(2010) Jennifer H. Cox et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for IL-27p28 as an antagonist of gp130-mediated signaling

(2010) Jason S Stumhofer et al.   NATURE IMMUNOLOGY

Interleukin-27 as a Negative Regulator of Human Neutrophil Function

(2010) J. P. Li et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance

(2009) Aya Shiokawa et al.   IMMUNOLOGY LETTERS

Interleukin-27 polymorphisms are associated with inflammatory bowel diseases in a Korean population

(2009) Chun-Shi Li et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

(2009) A. E. Troy et al.   JOURNAL OF IMMUNOLOGY

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

IL-27 Blocks RORc Expression to Inhibit Lineage Commitment of Th17 Cells

(2009) C. Diveu et al.   JOURNAL OF IMMUNOLOGY

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

(2009) Alberto J. León et al.   MEDIATORS OF INFLAMMATION

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD

(2008) Alejandro V. Villarino et al.   INTERNATIONAL IMMUNOLOGY