Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition

Pure total flavonoids from citrus attenuate non-alcoholic steatohepatitis via regulating the gut microbiota and bile acid metabolism in mice

(2021) Beihui He et al.   BIOMEDICINE & PHARMACOTHERAPY

Whistle signal variations among three Indo‐Pacific humpback dolphin populations in the South China Sea: a combined effect of the Qiongzhou Strait's geographical barrier function and local ambient noise?

(2021) Jing YUAN et al.   Integrative Zoology

Anti-NAFLD effect of defatted walnut powder extract in high fat diet-induced C57BL/6 mice by modulating the gut microbiota

(2021) Shu-meng Ren et al.   JOURNAL OF ETHNOPHARMACOLOGY

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

Dietary flaxseed oil rich in omega-3 suppresses severity of type 2 diabetes mellitus via anti-inflammation and modulating gut microbiota in rats

(2020) Lili Zhu et al.   Lipids in Health and Disease

The Effects of Bituminous Binder on the Performance of Gussasphalt Concrete for Bridge Deck Pavement

(2020) Guilian Zou et al.   Materials

Triterpene Acids of Loquat Leaf Improve Inflammation in Cigarette Smoking Induced COPD by Regulating AMPK/Nrf2 and NFκB Pathways

(2020) Tunyu Jian et al.   Nutrients

Statins activate the NLRP3 inflammasome and impair insulin signalling via p38 and mTOR

(2020) Brandyn D. Henriksbo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sweroside Prevents Non-Alcoholic Steatohepatitis by Suppressing Activation of the NLRP3 Inflammasome

(2020) Gabsik Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoglycemic Effect of Ginsenoside Rg5 Mediated Partly by Modulating Gut Microbiota Dysbiosis in Diabetic db/db Mice

(2020) Yange Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Probiotic Bifidobacterium lactis V9 attenuates hepatic steatosis and inflammation in rats with non-alcoholic fatty liver disease

(2020) Yan Yan et al.   AMB Express

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease

(2020) Hideki Fujii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

(2020) Susanne Gaul et al.   JOURNAL OF HEPATOLOGY

Metabolic liver disease in diabetes – From mechanisms to clinical trials

(2020) Bedair Dewidar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis

(2020) Antje Mohs et al.   JOURNAL OF HEPATOLOGY

Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice

(2020) Ting-Ting Cai et al.   Frontiers in Pharmacology

Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic syndrome in C57BL/6J mice fed with high-fat diet

(2020) Feng Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis

(2020) Hongdong Ma et al.   Oxidative Medicine and Cellular Longevity

Taohong Siwu Decoction Ameliorates Ischemic Stroke Injury Via Suppressing Pyroptosis

(2020) Mengmeng Wang et al.   Frontiers in Pharmacology

Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway

(2020) Jiawei Li et al.   PeerJ

Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats

(2020) Zhao-Rong Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes

(2019) Leigh Goedeke et al.   Annual Review of Pharmacology and Toxicology

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

The Role of Nrf2 in Liver Disease: Novel Molecular Mechanisms and Therapeutic Approaches

(2019) Dongwei Xu et al.   Frontiers in Pharmacology

Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/ HO ‐1 and AMPK signalling pathways

(2019) Bingyu Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Limonoid, 7-Deacetoxy-7-Oxogedunin (CG-1) from Andiroba (Carapa guianensis, Meliaceae) Lowers the Accumulation of Intracellular Lipids in Adipocytes via Suppression of IRS-1/Akt-Mediated Glucose Uptake and a Decrease in GLUT4 Expression

(2019) Chihiro Matsumoto et al.   MOLECULES

Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications

(2019) Elisabetta Bigagli et al.   Oxidative Medicine and Cellular Longevity

Eriobotrya japonica leaf extract attenuates airway inflammation in ovalbumin-induced mice model of asthma

(2019) Tae-muk Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Concurrent nonalcoholic liver disease and type 2 diabetes: diagnostic and therapeutic considerations

(2019) Marco Arrese et al.   Expert Review of Gastroenterology & Hepatology

DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome

(2019) Yochai Birnbaum et al.   BASIC RESEARCH IN CARDIOLOGY

NLRP3 inflammasome blockade reduces adipose tissue inflammation and extracellular matrix remodeling

(2019) Xabier Unamuno et al.   Cellular & Molecular Immunology

Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice

(2019) Kazuno Omori et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db / db mice

(2019) Hao Yang et al.   PHYTOTHERAPY RESEARCH

Anti-inflammatory and anti-arthritic activity in extract from the leaves of Eriobotrya japonica

(2019) Ângela Midori Kuraoka-Oliveira et al.   JOURNAL OF ETHNOPHARMACOLOGY

Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism

(2019) Fengjie Huang et al.   Nature Communications

Indole-3-Acetic Acid Alleviates Nonalcoholic Fatty Liver Disease in Mice via Attenuation of Hepatic Lipogenesis, and Oxidative and Inflammatory Stress

(2019) Yun Ji et al.   Nutrients

Regulation of Gut Microbiota and Metabolic Endotoxemia with Dietary Factors

(2019) Nobuo Fuke et al.   Nutrients

Gut Microbiota and Obesity: A Role for Probiotics

(2019) Ludovico Abenavoli et al.   Nutrients

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

(2019) Masa-Ki Inoue et al.   Cells

The therapeutic role of baicalein in combating experimental periodontitis with diabetes via Nrf2 antioxidant signaling pathway

(2019) Chunhui Zhu et al.   JOURNAL OF PERIODONTAL RESEARCH

Effects of newer antidiabetic drugs on nonalcoholic fatty liver and steatohepatitis: Think out of the box!

(2019) Golnaz Ranjbar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

(2019) Sujuan Ding et al.   Biomolecules

A novel sesquiterpene glycoside from Loquat leaf alleviates oleic acid-induced steatosis and oxidative stress in HepG2 cells

(2018) Tunyu Jian et al.   BIOMEDICINE & PHARMACOTHERAPY

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

(2018) Eleni Beli et al.   DIABETES

Diabetes, plasma glucose and incidence of fatty liver, cirrhosis and liver cancer: A prospective study of 0.5 million people

(2018) Yuanjie Pang et al.   HEPATOLOGY

Anti-Apoptosis and Anti-Fibrosis Effects of Eriobotrya Japonica in Spontaneously Hypertensive Rat Hearts

(2018) Jui-Ting Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Protective effects of rutin on liver injury in type 2 diabetic db/db mice

(2018) Weishi Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

(2018) Tao Zheng et al.   Oxidative Medicine and Cellular Longevity

Potential mechanisms linking gut microbiota and portal hypertension

(2018) Gyorgy Baffy   LIVER INTERNATIONAL

Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models

(2018) Ashfaq Ahmad et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL-17 and TNF in mice

(2017) Alexander Wree et al.   HEPATOLOGY

Ginsenoside Rb2 Alleviates Hepatic Lipid Accumulation by Restoring Autophagy via Induction of Sirt1 and Activation of AMPK

(2017) Qi Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked?

(2017) Kanwal Rehman et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

The Role of Tissue Macrophage-Mediated Inflammation on NAFLD Pathogenesis and Its Clinical Implications

(2017) Anna Alisi et al.   MEDIATORS OF INFLAMMATION

The chemical profiling of loquat leaf extract by HPLC-DAD-ESI-MS and its effects on hyperlipidemia and hyperglycemia in rats induced by a high-fat and fructose diet

(2017) Bo Chen et al.   Food & Function

Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

(2016) Priya Handa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

(2012) Tung-Ming Leung et al.   JOURNAL OF HEPATOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Surrogate measures of insulin resistance: of rats, mice, and men

(2009) Kieren Mather   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Increase of Theaflavin Gallates and Thearubigins by Acceleration of Catechin Oxidation in a New Fermented Tea Product Obtained by the Tea-Rolling Processing of Loquat (Eriobotrya japonica) and Green Tea Leaves

(2009) Takashi Tanaka et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY