DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome

Guidelines for experimental models of myocardial ischemia and infarction

(2018) Merry L. Lindsey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Remote ischemic preconditioning fails to reduce infarct size in the Zucker fatty rat model of type-2 diabetes: role of defective humoral communication

(2018) Joseph Wider et al.   BASIC RESEARCH IN CARDIOLOGY

Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells

(2018) Ao Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protecting the heart through MK2 modulation, toward a role in diabetic cardiomyopathy and lipid metabolism

(2018) Matthieu Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-κB signaling

(2018) Ying Hui et al.   LIFE SCIENCES

MicroRNA‑27a protects retinal pigment epithelial cells under high glucose conditions by targeting TLR4

(2018) Xiaolei Tang et al.   Experimental and Therapeutic Medicine

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

(2018) Hans Erik Bøtker et al.   BASIC RESEARCH IN CARDIOLOGY

Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet

(2018) Wei Zhu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-angiogenic effects of the DPP-4 inhibitor linagliptin via inhibition of VEGFR signalling in the mouse model of oxygen-induced retinopathy

(2018) Matthias Kolibabka et al.   DIABETOLOGIA

Of mice and men: models and mechanisms of diabetic cardiomyopathy

(2018) Christian Riehle et al.   BASIC RESEARCH IN CARDIOLOGY

Effect of Linagliptin vs Placebo on Major Cardiovascular Events in Adults With Type 2 Diabetes and High Cardiovascular and Renal Risk

(2018) Julio Rosenstock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

DPP4 Inhibition Ameliorates Cardiac Function by Blocking the Cleavage of HMGB1 in Diabetic Mice After Myocardial Infarction

(2017) Akihiko Sato et al.   International Heart Journal

Remote ischemic preconditioning attenuates EGR-1 expression following myocardial ischemia reperfusion injury through activation of the JAK-STAT pathway

(2017) H Mudaliar et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Anti-diabetic drug alogliptin protects the heart against ischemia-reperfusion injury via GLP-1 receptor-dependent and -independent pathways involving NO production in rabbits

(2017) Shinya Baba et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Significant role for microRNA-21 affecting toll-like receptor pathway in primary graft dysfunction after human lung transplantation

(2017) Zhongping Xu et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Lack of effect of prolonged treatment with liraglutide on cardiac remodeling in rats after acute myocardial infarction

(2017) Kasper Kyhl et al.   PEPTIDES

Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway

(2017) Masayoshi Suda et al.   PLoS One

Direct thrombin inhibition with dabigatran attenuates pressure overload-induced cardiac fibrosis and dysfunction in mice

(2017) Anping Dong et al.   THROMBOSIS RESEARCH

Atorvastatin inhibits the immediate-early response gene EGR1 and improves the functional profile of CD4+T-lymphocytes in acute coronary syndromes

(2017) Anna Severino et al.   Oncotarget

Effects of linagliptin and liraglutide on glucose- and angiotensin II-induced collagen formation and cytoskeleton degradation in cardiac fibroblasts in vitro

(2016) Xian-wei Wang et al.   ACTA PHARMACOLOGICA SINICA

Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts

(2016) Jianfeng Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Studies on the role of apoptosis after transient myocardial ischemia: genetic deletion of the executioner caspases-3 and -7 does not limit infarct size and ventricular remodeling

(2016) Javier Inserte et al.   BASIC RESEARCH IN CARDIOLOGY

MD2 mediates angiotensin II-induced cardiac inflammation and remodeling via directly binding to Ang II and activating TLR4/NF-κB signaling pathway

(2016) Jibo Han et al.   BASIC RESEARCH IN CARDIOLOGY

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

(2016) Fen Zhuge et al.   DIABETES

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice

(2016) Feng Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

U0126 attenuates ischemia/reperfusion-induced apoptosis and autophagy in myocardium through MEK/ERK/EGR-1 pathway

(2016) Anxing Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

No benefit of additional treatment with exenatide in patients with an acute myocardial infarction

(2016) Sebastiaan T. Roos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Egr-1 deficiency protects from renal inflammation and fibrosis

(2016) Li-Chun Ho et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Linagliptin attenuates diabetes-induced cerebral pathological neovascularization in a blood glucose-independent manner: Potential role of ET-1

(2016) Mohammed Abdelsaid et al.   LIFE SCIENCES

Soluble DPP-4 up-regulates toll-like receptors and augments inflammatory reactions, which are ameliorated by vildagliptin or mannose-6-phosphate

(2016) Dong-Sung Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Expression and function of toll-like receptor 4 and inflammasomes in cardiac fibroblasts and myofibroblasts: IL-1β synthesis, secretion, and degradation

(2016) Pia Boza et al.   MOLECULAR IMMUNOLOGY

Sitagliptin attenuates inflammatory responses in lipopolysaccharide-stimulated cardiomyocytes via nuclear factor-κB pathway inhibition

(2016) CHIEN-HUNG LIN et al.   Experimental and Therapeutic Medicine

DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation

(2015) Takanori Shinjo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

(2015) Emma Robinson et al.   BASIC RESEARCH IN CARDIOLOGY

Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®)

(2015) Nikolaus Marx et al.   Diabetes & Vascular Disease Research

Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition

(2015) Sen Shi et al.   KIDNEY INTERNATIONAL

Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes

(2015) Jennifer B. Green et al.   NEW ENGLAND JOURNAL OF MEDICINE

The DPP-4 inhibitor linagliptin and the GLP-1 receptor agonist exendin-4 improve endothelium-dependent relaxation of rat mesenteric arteries in the presence of high glucose

(2015) S.M. Salheen et al.   PHARMACOLOGICAL RESEARCH

Dipeptidyl peptidase-4 inhibition improves cardiac function in experimental myocardial infarction: Role of stromal cell-derived factor-1α

(2015) Kim A. Connelly et al.   Journal of Diabetes

The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK- and MAPK-dependent mechanisms

(2014) Yanmei Zeng et al.   Cardiovascular Diabetology

DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway

(2014) Yao Dai et al.   CARDIOVASCULAR DRUGS AND THERAPY

ERK/Egr-1 signaling pathway is involved in CysLT2 receptor-mediated IL-8 production in HEK293 cells

(2014) Kana Lin et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Dipeptidyl Peptidase IV Inhibitors and Ischemic Myocardial Injury

(2014) Alyssa H. Yoon et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Exendin-4 attenuates myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein expression

(2013) Gangying Hu et al.   Cardiology Journal

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury

(2013) Øystein Sandanger et al.   CARDIOVASCULAR RESEARCH

Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice

(2013) Nasib Ervinna et al.   ENDOCRINOLOGY

Let-7 in Cardiovascular Diseases, Heart Development and Cardiovascular Differentiation from Stem Cells

(2013) Mei-Hua Bao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats

(2013) Kosuke Kaji et al.   JOURNAL OF GASTROENTEROLOGY

Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies

(2013) Paulus Wohlfart et al.   Journal of Translational Medicine

Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes

(2013) William B. White et al.   NEW ENGLAND JOURNAL OF MEDICINE

Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus

(2013) Benjamin M. Scirica et al.   NEW ENGLAND JOURNAL OF MEDICINE

DPP4 Deficiency Exerts Protective Effect against H2O2 Induced Oxidative Stress in Isolated Cardiomyocytes

(2013) Hui-Chun Ku et al.   PLoS One

Mechanisms of disease: inflammasome activation and the development of type 2 diabetes

(2013) Ryan W. Grant et al.   Frontiers in Immunology

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

(2012) Baojun Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes

(2012) Yumei Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphodiesterase III Inhibition Increases cAMP Levels and Augments the Infarct Size Limiting Effect of a DPP-4 Inhibitor in Mice with Type-2 Diabetes Mellitus

(2012) Yochai Birnbaum et al.   CARDIOVASCULAR DRUGS AND THERAPY

Exenatide Reduces Final Infarct Size in Patients With ST-Segment–Elevation Myocardial Infarction and Short-Duration of Ischemia

(2012) Jacob Lønborg et al.   Circulation-Cardiovascular Interventions

Nlrp3 Inflammasome Activation in Type 2 Diabetes: Is It Clinically Relevant?

(2012) Vishwa Deep Dixit   DIABETES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury

(2012) Yoichiro Hirata et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction: The EXAMI study

(2012) Flip J.P. Bernink et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats

(2012) Berthold Hocher et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells

(2011) Ying Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner

(2011) Yochai Birnbaum et al.   BASIC RESEARCH IN CARDIOLOGY

The potential effects of anti-diabetic medications on myocardial ischemia–reperfusion injury

(2011) Yumei Ye et al.   BASIC RESEARCH IN CARDIOLOGY

MicroRNA regulation of innate immune responses in epithelial cells

(2011) Rui Zhou et al.   Cellular & Molecular Immunology

Elimination of the NLRP3-ASC Inflammasome Protects against Chronic Obesity-Induced Pancreatic Damage

(2011) Yun-Hee Youm et al.   ENDOCRINOLOGY

Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction

(2011) Jacob Lønborg et al.   EUROPEAN HEART JOURNAL

Expression of let-7i is associated with Toll-like receptor 4 signal in coronary artery disease: Effect of statins on let-7i and Toll-like receptor 4 signal

(2011) Mamoru Satoh et al.   IMMUNOBIOLOGY

DPP-4 (CD26) Inhibitor Alogliptin Inhibits Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice

(2011) Nga N Ta et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Cardiovascular effects of DPP-4 inhibition: Beyond GLP-1

(2011) Gian Paolo Fadini et al.   VASCULAR PHARMACOLOGY

Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction

(2010) Kyle T. Keyes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA

(2010) Yumei Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Downregulation of microRNA-29 by antisense inhibitors and a PPAR-γ agonist protects against myocardial ischaemia–reperfusion injury

(2010) Yumei Ye et al.   CARDIOVASCULAR RESEARCH

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Egr-1, the Potential Target of Calcium Channel Blockers in Cardioprotection with Ischemia/Reperfusion Injury in Rats

(2009) Zhanqin Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Glucagon-Like Peptide-1 Receptor Activation Modulates Pancreatitis-Associated Gene Expression But Does Not Modify the Susceptibility to Experimental Pancreatitis in Mice

(2009) J. A. Koehler et al.   DIABETES

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

(2009) M. H. Noyan-Ashraf et al.   DIABETES

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?

(2009) Sandrine Lecour   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice

(2008) Yumei Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Maturation-induces endothelial dysfunction via vascular inflammation in diabetic mice

(2008) Cuihua Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Hyperglycemia and Acute Coronary Syndrome

(2008) Prakash Deedwania et al.   CIRCULATION

Transcriptional regulation of lymphocyte development

(2008) Sheila Dias et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Exendin-4 induction of Egr-1 expression in INS-1 β-cells: Interaction of SRF, not YY1, with SRE site of rat Egr-1 promoter

(2008) Myung-Jun Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY