Iron overload results in hepatic oxidative stress, immune cell activation, and hepatocellular ballooning injury, leading to nonalcoholic steatohepatitis in genetically obese mice

Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

(2015) Michal Ganz et al.   Journal of Translational Medicine

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

(2014) P. Gutschow et al.   HAEMATOLOGICA

Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance

(2014) P. J. Meakin et al.   MOLECULAR AND CELLULAR BIOLOGY

Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding

(2014) Brittany V. Martin-Murphy et al.   PLoS One

Effects of iron overload on chronic metabolic diseases

(2014) José Manuel Fernández-Real et al.   Lancet Diabetes & Endocrinology

IFN-γ deficiency attenuates hepatic inflammation and fibrosis in a steatohepatitis model induced by a methionine- and choline-deficient high-fat diet

(2013) Xiao-Yu Luo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

(2013) J. S. Orr et al.   DIABETES

Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice

(2013) Justin R. Henning et al.   HEPATOLOGY

Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease

(2013) Bryan D. Maliken et al.   HEPATOLOGY

Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis

(2013) Priya Handa et al.   HEPATOLOGY

Effects of excess dietary iron and fat on glucose and lipid metabolism

(2013) Joo Sun Choi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282YHFEmutations

(2012) James E. Nelson et al.   HEPATOLOGY

Kuppfer Cells Trigger Nonalcoholic Steatohepatitis Development in Diet-induced Mouse Model through Tumor Necrosis Factor-α Production

(2012) Annie-Carole Tosello-Trampont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease

(2011) Kris V. Kowdley et al.   HEPATOLOGY

Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target

(2011) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

Serum Levels of Hepcidin in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease

(2011) Ebubekir Senates et al.   Metabolic Syndrome and Related Disorders

Adiponectin-Mediated Heme Oxygenase-1 Induction Protects Against Iron-Induced Liver Injury via a PPARα-Dependent Mechanism

(2010) Heng Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

Iron Homeostasis and the Inflammatory Response

(2010) Marianne Wessling-Resnick   Annual Review of Nutrition

Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease

(2010) James E. Nelson et al.   HEPATOLOGY

Hepatocellular ballooning in NASH

(2010) Stephen Caldwell et al.   JOURNAL OF HEPATOLOGY

Preventing oxidative stress: a new role for XBP1

(2009) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

CD8+ T cells drive adipose tissue inflammation – A novel clue for NASH pathogenesis?

(2009) Yury Popov et al.   JOURNAL OF HEPATOLOGY